Category: 455-68-5

Synthetic Route of 455-68-5, The chemical industry reduces the impact on the environment during synthesis 455-68-5, name is Methyl 3-fluorobenzoate, I believe this compound will play a more active role in future production and life.

EXAMPLE 2 72.4 parts of methyl 3-fluorobenzoate are dissolved in 300 parts of 100percent strength sulfuric acid with stirring at not more than 30° C., the solution is cooled to 0°-10° C. and then, over the course of 2 hours, a mixture of 32.7 parts of 98percent strength nitric acid and 78.3 parts of 100percent strength sulfuric acid is added dropwise with continuous cooling at 0°-10° C., and the mixture is stirred without cooling for 3 hours, during which the temperature of the nitrating mixture rises to 20° C. Then 175 parts of water are added dropwise, again with continuous cooling. The methyl fluoronitrobenzoate separates out as an oil which is separated off, washed until neutral in portions with 350 parts of water, and dried in vacuo at 100° C. 92 parts of methyl fluoronitrobenzoate are obtained, comprising 98.1percent methyl 5-fluoro-2-nitrobenzoate and 1.9percent methyl 3-fluoro-2-nitrobenzoate, with an s.p. of 34.0° C. and a purity (GC) of >99percent based on isomer mixture.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-fluorobenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoechst Aktiengesellschaft; US5543550; (1996); A;,
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Related Products of 455-68-5,Some common heterocyclic compound, 455-68-5, name is Methyl 3-fluorobenzoate, molecular formula is C8H7FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Different substituted carboxylic acids (20 mmol) (A) were stirred with thionyl chloride (100 mmol) in dry methanol (75 ml) or 5?6 h to synthesize corresponding methyl esters (B) (Scheme1). After extraction of esters in chloroform, solvent was evaporated and esters (66 mmol) were refluxed with hydrazine hydrate(330 mmol) in ethanol (75 ml) for 4?5 h. A solid was obtained upon removal of the solvent by rotary evaporation. The resulting solid was washed with hexane to afford hydrazide ligand (C). The spectral and analytical data are given below.

The synthetic route of 455-68-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ain, Qurrat Ul; Ashiq, Uzma; Jamal, Rifat Ara; Mahrooof-Tahir, Mohammad; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 115; (2013); p. 683 – 689;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 455-68-5, name is Methyl 3-fluorobenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H7FO2

General procedure: Substituted benzoic acid (1.0 mmol) was dissolved in thionylchloride and refluxed for 2 h, then the solvent was removed underreduced pressure to obtain the white solid. The white solid in methanol was added concentrated sulfuric acid (1 mL) and themixture was refluxed for 4 h, the solvent was removed to obtaincrude solid. The crude solid was extracted with ethyl acetate andwater. The solvents were evaporated to afford the pure product.Finally, the pure product was dissolved in ethanol, and the hydrazinehydrate was added. The mixture was refluxed for 9 h, and thesolvent was removed

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Lian, Zhi-Min; Sun, Juan; Zhu, Hai-Liang; Journal of Molecular Structure; vol. 1117; (2016); p. 8 – 16;,
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Ester – an overview | ScienceDirect Topics

Reference of 455-68-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 455-68-5 name is Methyl 3-fluorobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A round bottom centrifuge tube containing catalyst 4 (6.7 mol percent based on the percent phosphorus determined by elemental analysis or as otherwise stated in the footnotes of the corresponding Tables) was equipped with a rubber septum and two magnetic stir bars for extra stirring efficiency. After flushing the tube with argon, it was charged via syringe with a higher ester (5 mmol) and MeOH (5 mL) for transesterifications. For amidations, the tube was similarly charged with an ester (2 mmol), amino alcohol (2 mmol), and THF (3 mL). The reaction mixture was vigorously stirred at room temperature (23-25 ¡ãC) and progress of the reaction was monitored by thin layer chromatography. Upon completion of the reaction, the reaction mixture was filtered through Whatman No. 1 filter paper and washed with 3 .x. 10 mL of THF. The combined organics were subjected to short-path silica gel chromatography (0-20percent ethyl acetate in hexanes v/v) to obtain an analytically pure product. In the case of amides, products were purified using a short-path silica gel column eluted with dichloromethane/methanol (95:5, v/v).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 3-fluorobenzoate, and friends who are interested can also refer to it.

Reference:
Article; Chintareddy, Venkat Reddy; Ho, Hung-An; Sadow, Aaron D.; Verkade, John G.; Tetrahedron Letters; vol. 52; 49; (2011); p. 6523 – 6529;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

455-68-5, A common heterocyclic compound, 455-68-5, name is Methyl 3-fluorobenzoate, molecular formula is C8H7FO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The oil was thendissolved in EtOH, and NH2NH2.H2O (3 eq) was added.The mixture was refluxed for 10 h. CH2Cl2 (30 mL) was thenadded and extracted with distilled H2O (3 ¡Á 20 mL). Theorganic phase was separated, dried on anhydrous Na2SO4,and evaporated under vacuum to afford correspondinghydrazide 7a in very good yield (white solid, 1.02g, 93percent)

The synthetic route of 455-68-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Vu, Vu Van; Nhung, Trinh Thi; Thanh, Nguyen Thi; Chinh, Luu Van; Tien, Vu Dinh; Thuy, Vu Thu; Thi Thao, Do; Nam, Nguyen Hai; Koeckritz, Angela; Vu, Tran Khac; Journal of Chemistry; vol. 2017; (2017);,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 455-68-5, name is Methyl 3-fluorobenzoate, This compound has unique chemical properties. The synthetic route is as follows., 455-68-5

General procedure: Compounds 6a-t were synthesized from substituted benzoic acid via six steps according to the literature method as described. Various substituted benzoic acids 1a-t were treated with SOCl2 to give compounds 2a-t, which were reacted with CH3OH and EtN3 in CH2Cl2 at 0 to afford compounds 3a-t. Compounds 4a-t were prepared by the reaction of compounds 3a-t, hydrazine hydrate in CH3OH under reflux condition about 5h. Subsequently, compounds 5a-t were obtained by reaction of compounds 4a-t with CS2 and KOH in CH3OH. Compounds 6a-t were obtained by the cyclization reaction of compounds 5a-t in the presence of HCl at 0-5¡ãC.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Li, Liangjing; Ding, Hao; Wang, Baogang; Yu, Shichong; Zou, Yan; Chai, Xiaoyun; Wu, Qiuye; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 192 – 194;,
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Adding some certain compound to certain chemical reactions, such as: 455-68-5, name is Methyl 3-fluorobenzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 455-68-5. 455-68-5

REFERENCE EXAMPLE 68 Dimethyl 2-m-fluorophenyl-2-oxoethylphosphonate (68) STR87 To a stirred solution of dimethyl methylphosphonate (10.1 g, 81.2 mmol) in 100 ml of anhydrous THF was added dropwise n-butyl lithium (1.58N, 51.4 ml, 81.2 mmol) at -78¡ã C. under argon atmosphere. After 30 minutes, methyl m-fluorobenzoate (5.0 g, 32 mmol) was further added dropwise and the mixture was stirred for 30 minutes. The reaction solution was allowed to warm to 0¡ã C., diluted with 4.9 ml of acetic acid and 10 ml of water, and concentrated. 30 ml of water was added to the residue and the mixture was extracted with ethyl acetate (50 ml*2). The combined ethyl acetate layers were washed with water (20 ml*1) and brine (20 ml*1), dried over anhydrous sodium sulfate, and concentrated. The residue was distilled under reduced pressure to give an oil of dimethyl 2-m-fluorophenyl-2-oxo-ethylphosphonate (6.6 g, 26.8 mmol, yield 83.8percent, b.p. 132¡ã-134¡ã C./0.17 mmHg), which was assigned the structure by the following data: IR(Liquid film method): 3450, 3060, 2940, 2840, 1680, 1580, 1475, 1430, 1400, 1290, 1260, 1190, 1110, 1055, 1030, 870, 825, 790, 760, 710, 665 cm-1. NMR (90 MHz, CDCl3, delta): 3.62(2H, d, J=22.6 Hz), 3.79(6H, d, J=11.4 Hz), 7.15-7.9(4H, m).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Methyl 3-fluorobenzoate.

Reference:
Patent; Toray Industries, Inc.; US4775692; (1988); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics