Category: 4519-46-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4519-46-4, name is Methyl 2-bromoacrylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C4H5BrO2

(e) Methyl 2-[2-(Methyloxy)-8-quinolinyl]-2-propenoate To a solution of methyl 2-bromo-2-propenoate (452 mg, 2.74 mmol) (for a synthesis see Rachon, J.; Goedken, V.; Walborsky, H. J. Org. Chem. (1989), 54(5), 1006) in degassed tetrahydrofuran (10 ml) under an argon atmosphere was added [2-(methyloxy)-8-quinolinyl]boronic acid (506 mg, 2.49 mmol), bis(tri-t-butylphosphine)palladium (0) (25 mg, 0.05 mmol), bis(dibenzylideneacetone)palladium(0) (23 mg, 0.025 mmol) and potassium fluoride (477 mg, 8.217 mmol). The reaction was heated at 70 C. for 24 hours and then treated with water and dichloromethane. The aqueous fraction was re-extracted with dichloromethane. The combined organic fractions were then dried (MgSO4) and the solvent removed under reduced pressure. The residue was subjected to chromatography on silica gel using a ethyl acetate-hexane gradient. This provided the desired compound as a yellow solid (381 mg, 63%). MS (ES+) m/z 244 (MH+, 100%), 212 (80%).

The synthetic route of 4519-46-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cailleau, Nathalie; Davies, David Thomas; Esken, Joel Michael; Hennessy, Alan Joseph; Kusalakumari Sukumar, Senthil Kumar; Markwell, Roger Edward; Miles, Timothy James; Pearson, Neil David; US2008/221110; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4519-46-4, name is Methyl 2-bromoacrylate, A new synthetic method of this compound is introduced below., Formula: C4H5BrO2

EXAMPLE 5 2-Benzyloxycarbonyl-7-bromo-7-methoxycarbonyl-2-azabicyclo[2.2.2]oct-5-ene To 40 g. (0.2 moles) of N-benzyloxycarbonyl-1,2-dihydropyridine prepared as described in Example 3, 38 g. (0.23 moles) of freshly prepared methyl alpha-bromoacrylate and 2 g. of hydroquinone are added. The reaction mixture is allowed to stand at room temperature for 48 hours, under protection from light. The completion of the cycloaddition is shown by the disappearance of the lambdamax =305 nm from the UV spectrum. The reaction mixture is evaporated to an oily residue in vacuo, on a water bath of 40-50 C., and extracted from three 40-ml. portions of a benzene/brine mixture. The benzene phase is dried over magnesium sulfate and evaporated in vacuo, whereupon it is column chromatographed on a 30-fold amount of Kieselgel (0.063-0.2 mm), using a 10:1 mixture of benzene and ethyl acetate for the elution. Yield: 8 g. (0.01 moles), 11% based on the starting pyridine

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Richter Gedeon Vegyeszeti Gyar Rt.; US4563464; (1986); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4519-46-4, name is Methyl 2-bromoacrylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 4519-46-4

To a solution of methyl 2-bromo-2-propenoate (452 mg, 2.74 mmol) (for a synthesis see Rachon, J.; Goedken, V.; Walborsky, H. J. Org. Chem. (1989), 54(5), 1006) in degassed tetrahydrofuran (10 ml) under an argon atmosphere was added [2- (methyloxy)-8-quinolinyl]boronic acid (506 mg, 2.49 mmol), bis(tri-t- butylphosphine)palladium (0) (25 mg, 0.05 mmol), bis(dibenzylideneacetone)palladium(0) (23 mg, 0.025 mmol) and potassium fluoride (477 mg, 8.217 mmol). The reaction was heated at 7O0C for 24 hours and then treated with water and dichloromethane. The aqueous fraction was re-extracted with dichloromethane. The combined organic fractions were then dried (MgSO4) and the solvent removed under reduced pressure. The residue was subjected to chromatography on silica gel using a ethyl acetate-hexane gradient. This provided the desired compound as a yellow solid (381 mg, 63%).MS (ES+) m/z 244 (MH+, 100%), 212 (80%).

The synthetic route of 4519-46-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2008/128962; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics