Category: 431-47-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 431-47-0, name is Methyl 2,2,2-trifluoroacetate, A new synthetic method of this compound is introduced below., Formula: C3H3F3O2

Compound 24 (2.127 g, 3.6 mmol) was dissolved in DCM (10 g), and treated with triethylamine (0.1 mL) and methyltrifluoroacetate (0.922 g, 7.2 mmol) at 30 C. for 4 h. The reaction mixture was evaporated and purified on a silica gel column (50% hexanes/DCM?4% MeOH/DCM) to give compound 8b (1.914 g, 77.4%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AM Chemicals LLC; GUZAEV, Andrei Pavel; VVEDENSKIY, Vladimir V.; GOGOI, Khirud; (90 pag.)US2018/16232; (2018); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 431-47-0, name is Methyl 2,2,2-trifluoroacetate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

Synthesis Example 40 Synthesis of N-propargyltrifluoroacetamide Propargylamine (Aldrich, 25 g, 0.45 mol) was added dropwise to methyl trifluoroacetate (Tokyo Chemical Industry Co., Ltd., 69.2 g, 0.54 mol) cooled to 0 C. They were allowed to react at 0 C. for two hours to afford 43.8 g (86.0%) of N-propargyltrifluoroacetamide after purification by vacuum distillation (23 mmHg, boiling point; 77 C.).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; The Institute of Physical and Chemical Research; US6365350; (2002); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 431-47-0, name is Methyl 2,2,2-trifluoroacetate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2,2,2-trifluoroacetate

According to the procedure for 5d, 4-bromo-1-(pentan-3-yl)-1H-pyrazole (1.23 g, 5.68 mmol) was dissolvedin dry THF (15 mL) at -78 C under nitrogen and was stirred for 10 min. n-BuLi (2.5 M inhexanes, 2.38 mL, 5.96 mmol) was added drop wise to the solution was stirred for 2 hours at -78 C. After two hours, methyl trifluoroacetate (0.68 mL, 6.81 mmol) was added drop wise andstirred for 30 min at -78 C. The solution was then allowed to warm up to room temperature andlet stir for overnight. The mixture was then quenched with NH4Cl (20 mL) and extracted withether (50 mL), and dried over MgSO4. After concentration in vacuo (note: remove shortly afterthe ether is removed, because the compound is quite volatile), the residue was purified with flash chromatography over silica gel (DCM: hexane = 20:80) to yield the product as a liquid in 67%yield (0.90 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Camerino, Eugene; Wong, Dawn M.; Tong, Fan; Koerber, Florian; Gross, Aaron D.; Islam, Rafique; Viayna, Elisabet; Mutunga, James M.; Li, Jianyong; Totrov, Maxim M.; Bloomquist, Jeffrey R.; Carlier, Paul R.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 20; (2015); p. 4405 – 4411;,
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Synthetic Route of 431-47-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-47-0, name is Methyl 2,2,2-trifluoroacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Methyl trifluoroacetate (804 muL, 7.99 mmoles) and triethylamine (928 muL, 6.66 mmoles) were added to a suspension of glycine (500 mg, 6.66 mmoles) in methanol (2.5 mL). After the mixture was stirred vigorously for 18 h, 1 N HCl was added dropwise until the a pH of 2 was obtained. The reaction was added to ethyl acetate (30 mL) was washed with 1 N HCl (2 x 10 mL), dried over MgSO4, and concentrated in vacuo to yield the amide as a white solid (991 mg, 5.79 mmoles, 87%). LRMS: (CI+) calcd for C4H4NO3F3 (M + NH4): 189; found: 189. 1H NMR: spectrum is consistent with the predicted structure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trifluoroacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Johns Hopkins University School of Medicine; EP1235851; (2006); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 431-47-0, These common heterocyclic compound, 431-47-0, name is Methyl 2,2,2-trifluoroacetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of TFA-DOPA-OH (19)As seen in FIG. 2, step a, TFA-DOPA-OH (19) is synthesized by adding L-DOPA (39.4 g, 200 mmol), anhydrous MeOH (300 mL), and a magnetic stirring bar to a 1000 ml flask. The mixture was degassed with argon for 30 min, followed by addition of methyl trifluoroacetate (60 mL, 600 mmol) and triethylamine (112 mL, 800 mmol). The mixture was stirred at room temperature overnight. The volatile solvents were reduced by rotary evaporation and the residue was treated with 1 N HCl to a pH of ca. 1 and extracted with EtOAc. The organic layer was washed with 1N HCl and water, dried over MgSO4, and evaporated to give an off-white solid, 51.5 g (95%).

Statistics shows that Methyl 2,2,2-trifluoroacetate is playing an increasingly important role. we look forward to future research findings about 431-47-0.

Reference:
Patent; Northwestern University; US8227628; (2012); B2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 431-47-0, name is Methyl 2,2,2-trifluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 431-47-0, name: Methyl 2,2,2-trifluoroacetate

Example 7. Synthesis of a labeled compound of the present invention [a fluorescent labeling, 2′-deoxycytidine-5′-triphosphate derivative]; Mononucleotide (2′-deoxycytidine-5′-triphosphate) labeled with the compound [1] of the present invention was synthesized as follows according to the above-described synthesis route.(1) Synthesis of the partial linker (A); (i) Trifluoroacetylation (Tfa) (the first step); To 21 g of propagylamine, [the compound (51) in the above synthesis route], (manufactured by Tokyo Chemical Industry Co., Ltd.), methyl trifluoroacetate (MeOTfa) (54 g) and triethylamine (Et3N) (25 mL) were added, under ice-cooling, to be subjected to stirring at room temperature for 2 days. After completion of the reaction, purification was carried out under reduced pressure to give the compound (52), [the compound (52) in the above synthesis route], (56 g, yield; 98.1%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trifluoroacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Wako Pure Chemical Industries, Ltd.; EP2006289; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 431-47-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-47-0, name is Methyl 2,2,2-trifluoroacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Amixture of carbazole 5-h (0.68 mmol) and THF (15 ml)was stirred and treated by the addition of LiH (0.03 g,3.40 mmol) and methyl trifluoroacetate (0.26 g,2.03 mmol). The reaction mixture was stirred for 1.5-5 h at63, evaporated, and treated with cold 5% hydrochloricacid solution (20 ml). The precipitate was filtered off,washed with water, and then dried over P2O5.

The synthetic route of Methyl 2,2,2-trifluoroacetate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pugachov, Dmitriy E.; Kostryukova, Tatiana S.; Zatonsky, Georgy V.; Vatsadze, Sergey Z.; Vasil?ev, Nikolai V.; Chemistry of Heterocyclic Compounds; vol. 54; 5; (2018); p. 528 – 534; Khim. Geterotsikl. Soedin.; vol. 54; 5; (2018); p. 528 – 534,7;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 431-47-0, name is Methyl 2,2,2-trifluoroacetate, A new synthetic method of this compound is introduced below., Application In Synthesis of Methyl 2,2,2-trifluoroacetate

Compound 24 (2.127 g, 3.6 mmol) was dissolved in DCM (10 g), and treated with triethylamine (0.1 mL) and methyltrifluoroacetate (0.922 g, 7.2 mmol) at 30 C. for 4 h. The reaction mixture was evaporated and purified on a silica gel column (50% hexanes/DCM?4% MeOH/DCM) to give compound 8b (1.914 g, 77.4%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; AM Chemicals LLC; GUZAEV, Andrei Pavel; VVEDENSKIY, Vladimir V.; GOGOI, Khirud; (90 pag.)US2018/16232; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 431-47-0,Some common heterocyclic compound, 431-47-0, name is Methyl 2,2,2-trifluoroacetate, molecular formula is C3H3F3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Propargyl amine (4.00 g, 72.62 mmol, 1.00 equiv.) was added dropwise to methyl trifluoroacetate (11.16 g, 87.15 mmol, 1.20 equiv.) at 0C. The reaction mixture was stirred at 0C for 2 h and then concentrated under reduced pressure to remove methanol. The product was purified by vacuum distillation yielding propargyltrifluoroacetamide as a colorless liquid (9.59 g, 87 %). The structure was confirmed by 1H- and 19F-NMR.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2,2,2-trifluoroacetate, its application will become more common.

Reference:
Patent; Pierce Biotechnology, Inc.; Etienne, Christopher; Opperman, Kay; Kaboord, Barbara; Meier, Scott; Schultz, Jean-Samuel; EP2669291; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 431-47-0, name is Methyl 2,2,2-trifluoroacetate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 431-47-0

Trifluoroacetanilide (100 mg, 0.46 mmol), DMF (4 mL), potassium t-butoxide (153 mg, 1.37 mmol, 3 eq.) was added to the reaction mixture in turn, and stirred at room temperature for 5 minutes.After the potassium tert-butoxide was uniformly dispersed, methyl trifluoroacetate (0.19 mL, 1.84 mmol, 4 eq.) was slowly injected into the reaction flask, and after stirring at 60 C for 10 hours, stirring was stopped.Extract twice with ethyl acetate and distilled water, then wash with saturated NaCl solution.The organic phases were combined, and the organic phase was dried over anhydrous magnesium sulfate.Magnesium sulfate was removed by filtration, and the solvent was evaporated to give purified N-(4-methoxyphenyl)-N-methyltrifluoroacetamide (88 mg, yield 83%).

According to the analysis of related databases, 431-47-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Petrochemical College; Xiao Duoduo; Zheng Xin; Zeng Jiechun; Huang Jiawei; Zhou Rujin; Guan Ying; Liang Jieling; (8 pag.)CN109369506; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics