Application of 428-97-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 428-97-7 name is Diethyl 2,2-difluoropentanedioate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 126 Ethyl 4,4-Difluoro-5-hydroxypentanoate (c) Diethyl 2,2-difluoroglutarate (2.50 g, 11.1 mmol) was dissolved in 400 ml of absolute ethanol. Sodium borohydride (0.53 g, 13.73 mmol) was added and the resulting solution was stirred vigorously under N2 at room temperature for 7 hrs as the solution turned yellow. The ethanol was evaporated in vacuo, and the residue taken up in water EtOAc and acidified with 5% HCl. The ethyl acetate extract yielded after workup 1.50 g of the hydroxy-ester. It was filtered through a short column (50 g) of silica gel (eluted with ether) to give 1.30 g (64% yield) of the title compound as a colorless oil. Tlc on silica gel: Rf 0.44 in EtOAc:hexane 1:3
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diethyl 2,2-difluoropentanedioate, and friends who are interested can also refer to it.
Reference:
Patent; The University of Chicago; US4324730; (1982); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics