Category: 426-65-3

Related Products of 426-65-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426-65-3, name is Ethyl Pentafluoropropionate, This compound has unique chemical properties. The synthetic route is as follows.

A solution of BOC protected aniline (14 g, 72 mmol) in anhydrous ether (150 mL) at -15 C. under nitrogen was treated with a solution of t-butyllithium (1.7 M in pentane, 106 mL, 183 mmol). The reaction mixture was stirred at -15 C. for 4 hrs, cooled to -78 C., and treated with ethyl pentafluoropropionate (13 mL, 88 mmol). The mixture was allowed to slowly warm to rt and brine (500 mL) was added. The organic layer was separated, dried (MgSO4), and concentrated. The residue was taken up in methylene chloride (100 mL) and treated with TFA (5 mL) at 0 C. under nitrogen. After 1.5 hrs, the solution was treated with a cold sodium bicarbonate solution (3N, 100 mL) and organic layer was separated, dried (MgSO4), and concentrated. The crude residue (5 g, 21 mmol) was then taken up in methylene chloride (80 mL) and treated with NBS (3.6 g, 20 mmol) in portions at rt under nitrogen. After 1 hr, the solution was washed with aqueous 3N sodium bicarbonate solution (3¡Á20 mL), dried (MgSO4), and concentrated to give 1-(2-amino-5-bromophenyl)-2,2,3,3,3-pentafluoropropan-1-one as a yellow solid (6 g, 25% in three steps). 1H NMR (DMSO-d6): delta 7.97 (s, 2H), 7.67 (d, J=2.3 Hz, 1H), 7.56 (dd, J=9.2, 2.2 Hz, 1H), 6.94 (d, J=9.3 Hz, 1H); MS (ESI) m/z 318/320 ([M+H]+); MS (ESI) m/z 316/318 ([M-H]-); Anal. calcd for C9H5BrF5NO: C, 33.99; H, 1.58; N, 4.40. Found: C, 34.27; H, 1.75; N, 4.22.

The chemical industry reduces the impact on the environment during synthesis Ethyl Pentafluoropropionate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Wyeth; US2005/215539; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 426-65-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426-65-3, name is Ethyl Pentafluoropropionate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of alkyne (1.0 eq) in THF (0.5 M) was added dropwise n-BuLi in solution in hexanes (1.1 eq) at -78 C. The mixture was stirred for 1 h at -78 C and ethyl trifluoroacetate (1.5 eq) was added. After the complete consumption of the alkyne (TLC), the mixture was diluted with MeOH (same volume than THF). The mixture was allowed to warm up to 0 C and NaBH4 (1.0 eq) was added. The mixture was stirred overnight while warming up to room temperature. The reaction was then quenched with a saturated solution of NH4Cl, extracted with Et2O (x3), washed with water and brine, dried over MgSO4 and concentrated under reduced pressure to give the alpha-trifluoromethyl secondary propargylic alcohol. The crude product was purified by flash column chromatography to afford the pure product.

The chemical industry reduces the impact on the environment during synthesis Ethyl Pentafluoropropionate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Boreux, Arnaud; Lambion, Aubin; Campeau, Dominic; Sanita, Marina; Coronel, Ruben; Riant, Olivier; Gagosz, Fabien; Tetrahedron; vol. 74; 38; (2018); p. 5232 – 5239;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 426-65-3, name is Ethyl Pentafluoropropionate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 426-65-3

General procedure: Sodium hydride (4.0 g, 100 mmol, 60% dispersion in mineral oil) was placed in a 500mL round-bottom flack and 50 mL of dry hexane was added. The suspension was stirred for a short time with a magnetic stirring bar and kept until the hexane layer became clear (20-30 min). Hexane was cautiously removed with a glass pipette until a wet paste of NaH remained. This procedure was repeated twice. After that, THF (150mL) was added with vigorous stirring. Anhydrous EtOH (0.5 mL) was added in oneportion at 0 C, followed by the dropwise addition of a solution of 2-acetylthiophene (6.3g, 50 mmol, 5.42 mL) and methyl or ethyl ester of the respective perfluorinatedcarboxylic acid (50.5 mmol) in 30 mL of THF. The white suspension rapidly turns pink and then reddish-brown. Caution Hydrogen evolved during the addition and notable effervescence was observed. The rate of addition was maintained to control the evolution of hydrogen; usually the addition takes 60-80 min. When gas evolution ceased, the cooling bath was removed and the reaction mixture was stirred for 5 h. After that, the dark brown solution with a small amount of precipitate was re-cooled to 0 C,10 mL of anhydrous EtOH was added slowly to decompose traces of NaH, and the resulting solution was stirred for 30 min. The solvent was removed by evaporation under reduced pressure (100 Torr, bath temperature 40 C), then EtOAc (40 mL) andsubsequently a mixture of conc. HCl (20 mL) and crushed ice (80 mL) were added tothe residue. The resulting turbid liquid was shaken by hand until two clear layers formed. The organic phase was separated and the aqueous phase was then extracted with EtOAc (3 ¡Á 50 mL). The combined organic fractions were washed with brine (50mL), dried over MgSO4 and evaporated to dryness. The resulting brown oil was distilled in vacuo (2-3 Torr). The main fraction is pure enough. Additional portions of pure diketone can be separated from low-boiling fractions by precipitation as a copper salt. Decomposition should be performed with HCl (procedure A).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 426-65-3.

Reference:
Article; Taydakov, Ilya V.; Kreshchenova, Yuliya M.; Dolotova, Ekaterina P.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 3106 – 3111;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

426-65-3, Name is Ethyl Pentafluoropropionate, 426-65-3, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

EXAMPLE 2 Potassium perfluoropropionate The procedure of Example 1 was followed using ethyl perfluoropropionate (4.8 g, 25 mmol), potassium trimethylsilanolate (3.2 g, 25 mmol), and dry ether (150 mL). Potassium perfluoropropionate (4.7 g, 93% yield) was isolated as a white solid: 19 F NMR (D2 O) delta -79.5 (m, CF3, 3F), -117.5 (m, CF2, 2F). Anal. Calcd. for C3 F5 KO2: C, 17.83; F, 47.00; K, 19.35. Found: C, 17.52; F, 46.83; K, 19.24.

Statistics shows that Ethyl Pentafluoropropionate is playing an increasingly important role. we look forward to future research findings about 426-65-3.

Reference:
Patent; E. I. Du Pont de Nemours and Company; US4723016; (1988); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

426-65-3, name is Ethyl Pentafluoropropionate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 426-65-3

P-xylene (30 mL) of ethyl 2,2,3,3,3-pentafluoropropanoate (S-1) (7.69 g, 40.0 mmol)1,3-diaminopropan-2-ol (S-2) (3.61 g, 40.0 mmol) was added to the solution, and the mixture was stirred at 160 C. for 4 hours.The solvent was distilled off under reduced pressure,Compound (S-3) (yield: 10.1 g)As a yellow oil.

Statistics shows that 426-65-3 is playing an increasingly important role. we look forward to future research findings about Ethyl Pentafluoropropionate.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; Watanabe, Atsushi; Sato, Yuki; ogura, Keiji Tamada; Tatsumi, Yoshiyuki; (283 pag.)JP2018/145180; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics