Category: 426-65-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 426-65-3, name is Ethyl Pentafluoropropionate, A new synthetic method of this compound is introduced below., name: Ethyl Pentafluoropropionate

Ethyl pentafluoropropylenate (14.6 g) and hydrazine monohydrate (3.6 g) were refluxed in tetrahydrofuran (300 ml) for 1 hour. After cooling to room temperature, trifluoroacetamidine (10.0 g) was added dropwise to the mixture and it was refluxed for 3 hours. After finishing the reaction, satu- rated aqueous solution of sodium hydrogen carbonate was added thereto and the mixture was extract- ed with ethyl acetate. After drying the organic layer with anhydrous magnesium sulfate, the solvent was distilled off to obtain crude 3-pentafluoroethyl-5-trifluoromethyl-lH- (1, 2, 4)-triazole (7.9 g).

The synthetic route of 426-65-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE AG; WO2005/95351; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426-65-3, name is Ethyl Pentafluoropropionate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Ethyl Pentafluoropropionate

Pentafluoroethyl cyclopropylethynyl ketone, (XVI) can be synthesized in an analogous fashion using ethyl pentafluoropropionate in the above reaction.

According to the analysis of related databases, 426-65-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pierce, Michael Ernest; Radesca, Lilian Alicia; US6348616; (2002); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 426-65-3, name is Ethyl Pentafluoropropionate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 426-65-3

General procedure: Sodium hydride (4.0 g, 100 mmol, 60% dispersion in mineral oil) was placed in a 500mL round-bottom flack and 50 mL of dry hexane was added. The suspension was stirred for a short time with a magnetic stirring bar and kept until the hexane layer became clear (20-30 min). Hexane was cautiously removed with a glass pipette until a wet paste of NaH remained. This procedure was repeated twice. After that, THF (150mL) was added with vigorous stirring. Anhydrous EtOH (0.5 mL) was added in oneportion at 0 C, followed by the dropwise addition of a solution of 2-acetylthiophene (6.3g, 50 mmol, 5.42 mL) and methyl or ethyl ester of the respective perfluorinatedcarboxylic acid (50.5 mmol) in 30 mL of THF. The white suspension rapidly turns pink and then reddish-brown. Caution Hydrogen evolved during the addition and notable effervescence was observed. The rate of addition was maintained to control the evolution of hydrogen; usually the addition takes 60-80 min. When gas evolution ceased, the cooling bath was removed and the reaction mixture was stirred for 5 h. After that, the dark brown solution with a small amount of precipitate was re-cooled to 0 C,10 mL of anhydrous EtOH was added slowly to decompose traces of NaH, and the resulting solution was stirred for 30 min. The solvent was removed by evaporation under reduced pressure (100 Torr, bath temperature 40 C), then EtOAc (40 mL) andsubsequently a mixture of conc. HCl (20 mL) and crushed ice (80 mL) were added tothe residue. The resulting turbid liquid was shaken by hand until two clear layers formed. The organic phase was separated and the aqueous phase was then extracted with EtOAc (3 × 50 mL). The combined organic fractions were washed with brine (50mL), dried over MgSO4 and evaporated to dryness. The resulting brown oil was distilled in vacuo (2-3 Torr). The main fraction is pure enough. Additional portions of pure diketone can be separated from low-boiling fractions by precipitation as a copper salt. Decomposition should be performed with HCl (procedure A).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 426-65-3.

Reference:
Article; Taydakov, Ilya V.; Kreshchenova, Yuliya M.; Dolotova, Ekaterina P.; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 3106 – 3111;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 426-65-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 426-65-3 as follows.

4,4,5,5,5-pentafluoro-1-phenylpentane-1,3-dione, lithium enolate salt (Scheme 1, formula 3; X=F) A solution of lithium hexamethyldisilazide in THF (1.0 M, 7.6 mL, 7.6 mmol, 1.0 eq.) was added to dry Et2O (12 mL) and cooled to -78 C. To the cooled solution was added a solution of acetophenone (0.90 g, 7.6 mmol) in Et2O (8 mL), dropwise over 15 minutes. The mixture was stirred at -78 C. for 30 minutes, then a solution of ethyl 2,2,3,3-3-pentafluoropropionate (1.26 mL, 7.95 mmol, 1.05 eq.) in Et2O (6 mL) was added in one portion. The dry ice bath was removed, and the reaction was stirred, warming to room temperature, for 1 hour. The reaction was then evaporated to yield a tacky solid which was triturated with hexane repeatedly to yield 2.04 g (99%) of 3 as a pink solid: Rf 0.38 (50% EtOA/hexanes): 1H NMR (DMSO-d6) S 7.96 (d, 2H), 7.64 (t, 1H), 7.52 (dt, 2H), 6.64 (s, 1H).

According to the analysis of related databases, 426-65-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MICROBIOTIX, INC.; Basu, Arnab; Mills, Debra M.; Peet, Norton P.; Williams, John D.; US9101635; (2015); B2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 426-65-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426-65-3, name is Ethyl Pentafluoropropionate, This compound has unique chemical properties. The synthetic route is as follows.

Step A: 1 -Ethoxy-2,2,3,3,3-pentafluoro-propan-1 -olEthyl 2,2,3,3,3-pentafluoropropionate (10.99 grams, 57.2 mmol) was dissolved in anhydrous methanol (57 ml) and cooled under argon to 6O0C. Sodium borohydride (2.16 grams, 57.2 mmol) was added in four portions. After the addition was complete, stirring was continued for one hour and the temperature was held below -45C. The mixture was cooled to -60C and 1M hydrochloric acid (172 ml) was added dropwise so that the temperature remained below -45C. The mixture was slowly warmed to room temperature and extracted with diethylether (3×100 ml). The combined organic phases were washed with water (two times), dried over magnesium sulfate, the solvent was removed under reduced pressure. 9.76 g (50.3 mmol, 88%) were obtained and used directly in the next step.

The chemical industry reduces the impact on the environment during synthesis Ethyl Pentafluoropropionate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; INTERVET INC.; BERGER, Michael; ECK, Marko; KERN, Christopher; WO2013/144179; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 426-65-3, name is Ethyl Pentafluoropropionate, A new synthetic method of this compound is introduced below., Computed Properties of C5H5F5O2

Sodium ethoxide (7.49 g, 0.11 mol) was suspended in methyl tert-butyl ether (anhydrous, 200ml) under nitrogen. Ethyl 2,2,3, 3,3-pentafluoropropanoate (14.8 ml, 0.1 mol) was added dropwise with stirring followed by ethyl acetate (10.7 ml, 0.11 mol). Stirring was continued for 45 minutes at ambient temparature, for one hour at 50C and overnight at ambient tempeature. The mixture was cooled to 0C and acidified with HC1 (1M, 80 ml), brine was added (80 ml), the layers were separated, and the aqueous layer was back-extracted with in methyl tert-butyl ether (80 ml). The combined organic layers were dried over Na2S04and concentrated under reduced pressure to yield 14.6 gram (0.062 mol, 62% yield). H-NMR (300 MHz, CDC13): delta 1 1.96 (s), 5.59 (s), 4.11-4.26 (m), 3.70 (m), 1.21-1.29 (m);19F-NMR (282 MHz, CDC13): delta -81.8 (s), -83.3 (s), -122.7 (s), -123.6 (s); MS 189 (M-OCH2CH3)

The synthetic route of 426-65-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; INTERVET INC.; BERGER, Michael; VEIT, Stephan; NIEDERMANN, Hans, Peter; KAPPESSER, Tobias; STUTZ, Alfred; WO2015/177179; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 426-65-3, name is Ethyl Pentafluoropropionate, A new synthetic method of this compound is introduced below., Recommanded Product: 426-65-3

Ethyl pentafluoropropylenate (14.6 g) and hydrazine monohydrate (3.6 g) were refluxed in tetrahydrofuran (300 ml) for 1 hour. After cooling to room temperature, trifluoroacetamidine (10.0 g) was added dropwise to the mixture and it was refluxed for 3 hours. After finishing the reaction, satu- rated aqueous solution of sodium hydrogen carbonate was added thereto and the mixture was extract- ed with ethyl acetate. After drying the organic layer with anhydrous magnesium sulfate, the solvent was distilled off to obtain crude 3-pentafluoroethyl-5-trifluoromethyl-lH- (1, 2, 4)-triazole (7.9 g).

The synthetic route of 426-65-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE AG; WO2005/95351; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 426-65-3, name is Ethyl Pentafluoropropionate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Ethyl Pentafluoropropionate

Pentafluoroethyl cyclopropylethynyl ketone, (XVI) can be synthesized in an analogous fashion using ethyl pentafluoropropionate in the above reaction.

According to the analysis of related databases, 426-65-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pierce, Michael Ernest; Radesca, Lilian Alicia; US6348616; (2002); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 426-65-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 426-65-3 as follows.

EXAMPLE 52 3-Methyl-2-[5-(pentafluoropropanoylamino)pentan-1-ylthio]-1,4,7b-triazacyclopent[cd]indene To a solution of 275 mg (1.00 mmol) of 3-methyl-2-[5-(amino)pentan-1-ylthio]-1,4,7b-triazacyclopent[cd]indene in 30 ml of acetonitrile were added 0.19 ml (1.36 mmol) of triethylamine and 231 mg (1.20 mmol) of pentafluoropropionic acid ethyl ester. The mixture was stirred for 15 hours at room temperature, and the the solvent was distilled off. To the residue was added ethyl acetate, washed with water, and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by column chromatography (eluent: ethyl acetate) to afford 245 mg (58.1%, a pale brown solid) of the desired compound. NMR(200 MHz,CDCl3)delta: 1.50-1.80(4H,m), 1.96(2H,m), 2.90(3H,s), 3.44(2H,m), 3.52(2H,t,J=7.0 Hz), 6.68(1H,br), 7.67(1H,d,J=7.8 Hz), 7.73(1H,d,J=8.0 Hz), 7.95(1H,dd,J=8.0,7.8 Hz).

According to the analysis of related databases, 426-65-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US5958942; (1999); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 426-65-3, name is Ethyl Pentafluoropropionate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 426-65-3, Computed Properties of C5H5F5O2

Compound 14 (1.2 g, 3.7 mmol) was dissolved in dry toluene (40 mL). Sodium hydride (0.18 g, 40% dispersion in oil) was added, and the mixture was stirred for 15 min at rt. Ethyl pentafluoropropionate (1.1 niL, 7.4 mmol) was added, and the mixture was stirred overnight at rt. Hydrochloric acid (IM, 40 mL) and dichloromethane were added, and the mixure was stirred for 10 min.The organic phase was separated, and the aqueus phase was extracted twice with dichloromethane. The combined organic phases were dried and concentrated. . Purification on silica gel (eluent 10% MeOH in CH2Cl2, v/v) yielded the title compound. 1H NMR (CDCl3): ? 7.71 (2H, d, J 7.9); 7.36 (IH, d, J 3.8); 7.30 (2H, d, J 7.9); 6.73 (IH, d, J 3.4); 6.06 (IH, s); 4.21 (2H, t, / 6.5); 3.12 (2H, m); 2.42 (3H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; WALLAC OY; WO2009/115644; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics