Category: 4248-19-5

《Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics》 was published in Journal of the American Chemical Society in 2020. These research results belong to Nicolaou, K. C.; Das, Dipendu; Lu, Yong; Rout, Subhrajit; Pitsinos, Emmanuel N.; Lyssikatos, Joseph; Schammel, Alexander; Sandoval, Joseph; Hammond, Mikhail; Aujay, Monette; Gavrilyuk, Julia. Recommanded Product: 4248-19-5 The article mentions the following:

The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A-F and yangpumicin A. This family of natural products provides opportunities in total synthesis, biol., and medicine due to their novel and challenging mol. structures, intriguing biol. properties and mechanism of action, and potential in targeted cancer therapies. Herein, the total syntheses of tiancimycins A and B, yangpumicin A, and a number of related anthraquinone-fused enediynes are described. Biol. evaluation of the synthesized compounds revealed extremely potent cytotoxicities against a number of cell lines, thus enriching the structure-activity relationships within this class of compounds The findings of these studies may facilitate future investigations directed toward antibody-drug conjugates for targeted cancer therapies and provide inspiration for further advances in total synthesis and chem. biol.tert-Butyl carbamate(cas: 4248-19-5Recommanded Product: 4248-19-5) was used in this study.

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baldwin, Aaron F.; Caporello, Michaella A.; Chen, Guoyong; Goetz, Adam E.; Hu, Weifeng; Jin, Chengfeng; Knopf, Kevin M.; Li, Zhifeng; Lu, Cuong V.; Monfette, Sebastien; Puchlopek-Dermenci, Angela L. A.; Shi, Feng published their research in Organic Process Research & Development in 2021. The article was titled 《Kilogram-Scale Preparation of an Aminopyrazole Building Block via Copper-Catalyzed Aryl Amidation》.Related Products of 4248-19-5 The article contains the following contents:

We describe a scalable method for preparing an aminopyrazole building block using copper-catalyzed amidation with acetamide as an ammonia surrogate (4-bromo-1-methyl-1H-pyrazole + acetamide →→ 1-methyl-1H-pyrazol-4-amine hydrochloride). This procedure provides an alternative to the standard nitration/reduction sequence and avoids energetic intermediates, specialized hydrogenation equipment, and potentially genotoxic impurities that arise from nitro reduction The chem. has been successfully scaled to produce >50 kg of the target compound and demonstrate the viability of this alternative route. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Related Products of 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Related Products of 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 4248-19-5In 2019 ,《Identification of protonated primary carbamates by using gas-phase ion-molecule reactions followed by collision-activated dissociation in tandem mass spectrometry experiments》 appeared in Organic Process Research & Development. The author of the article were Niyonsaba, Edouard; Easton, Mckay W.; Liu, Judy K. Y.; Yu, Zaikuan; Sheng, Huaming; Kong, John Y.; Zhang, Zhoupeng; Easterling, Leah F.; Milton, Jacob; Kenttamaa, Hilkka I.. The article conveys some information:

The levels of potentially mutagenic impurities (PMIs) in active pharmaceutical ingredients are highly regulated and must be below a critical safety threshold. One class of PMIs is primary carbamates, which are formed during drug manufacturing and formulation. To comply with safety regulations, it is critically important to develop anal. techniques that enable the identification of primary carbamates during the drug development process. In this study, tandem mass spectrometry combined with gas-phase ion-mol. reactions as well as collision-activated dissociation (CAD) is demonstrated to enable the identification of protonated primary carbamates. Primary carbamates were protonated via atm. pressure chem. ionization (APCI) in a linear quadrupole ion trap mass spectrometer, isolated, and allowed to react with trimethoxymethylsilane (TMMS) introduced into the ion trap via an external reagent mixing manifold. Protonated primary carbamates reacted with TMMS to form an adduct ion, [M + H + TMMS]+, and an adduct ion that had lost methanol, [M + H + TMMS – MeOH]+. Upon CAD, the [M + H + TMMS – MeOH]+ product ions generated a diagnostic fragment ion via loss of isocyanic acid. Quantum chem. calculations were employed to explore the possible mechanisms for the formation of the product ions upon ion-mol. reactions and for the fragmentation of the [M + H + TMMS – MeOH]+ product ion. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl carbamate(cas: 4248-19-5Related Products of 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Related Products of 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Palladium-Catalyzed Amidation and Amination of (Hetero)aryl Chlorides under Homogeneous Conditions Enabled by a Soluble DBU/NaTFA Dual-Base System》 were Beutner, Gregory L.; Coombs, John R.; Green, Rebecca A.; Inankur, Bahar; Lin, Dong; Qiu, Jun; Roberts, Frederick; Simmons, Eric M.; Wisniewski, Steven R.. And the article was published in Organic Process Research & Development in 2019. Formula: C5H11NO2 The author mentioned the following in the article:

The palladium-catalyzed coupling of aryl and heteroaryl chlorides with primary amides under mild homogeneous reaction conditions is reported. Successful C-N coupling is enabled using a unique “”dual-base”” system consisting of DBU and NaTFA, which serve as proton acceptor and halide scavenger, resp., using low catalyst loadings (0.5 mol %) with readily available, air-stable palladium precatalysts. The DBU/NaTFA system also enables the room-temperature coupling of primary aryl amines with aryl chlorides and is tolerant of a variety of base-sensitive functional groups. In the experimental materials used by the author, we found tert-Butyl carbamate(cas: 4248-19-5Formula: C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Formula: C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Hydrophobic Pockets of HPMC Enable Extremely Short Reaction Times in Water》 was published in ACS Sustainable Chemistry & Engineering in 2020. These research results belong to Petkova, Desislava; Borlinghaus, Niginia; Sharma, Sudripet; Kaschel, Johannes; Lindner, Tanja; Klee, Johanna; Jolit, Anais; Haller, Vanessa; Heitz, Stephanie; Britze, Katarina; Dietrich, Justin; Braje, Wilfried M.; Handa, Sachin. Application of 4248-19-5 The article mentions the following:

A methodol. for formation of ligated ultrasmall in-situ generated Pd nanoparticles in the hydrophobic pockets of benign cellulose derivative hydroxypropyl methylcellulose (HPMC) for chem. reactions to proceed very fast in water under mild reaction conditions was reported. Unprecedented short reaction times were exemplified for the Buchwald-Hartwig amination reaction of aryl bromides and aryl amines using in-situ generated Pd nanoparticles in aqueous HMPC solution to afford substituted aryl amines RNHR1 [R = 1-naphthyl, 3-MeC6H4, 2-MeOC6H4, etc.; R1 = Ph, 4-MeC6H4, 1-naphthyl, etc.]. In addition, very short reaction times were also demonstrated for the peptide coupling of carboxylic acids and amines using in-situ generated Pd nanoparticles in aqueous HMPC solution to afford aryl amides R2C(O)NR3R4 [R2 = Bn, 4-ClC6H4, 4-BrC6H4, etc.; R3 = OMe, n-hexyl, 3,5-(Me)2C6H3, etc.; R4 = H, Me, etc.]. After reading the article, we found that the author used tert-Butyl carbamate(cas: 4248-19-5Application of 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application of 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Diastereodivergent Intermolecular 1,2-Diamination of Unactivated Alkenes Enabled by Iodine Catalysis》 was written by Minakata, Satoshi; Miwa, Hayato; Yamamoto, Kenya; Hirayama, Arata; Okumura, Sota. Formula: C5H11NO2This research focused onvicinal diamine diastereoselective preparation; iodine catalyst stereoselective diamination alkene nitrobenzenesulfonamide chlorosulfamide; diastereodivergent diamination internal alkene iodine catalyst nitrobenzenesulfonamide chlorosulfamide. The article conveys some information:

The stereospecific, substrate (nitrogen source)-controlled intermol. anti- and syn-1,2-diaminations of unactivated alkenes using iodine as the catalyst is reported. The combined use of the two potential methods provides access to both diastereomers of 1,2-diamines from E- and Z-alkenes, and the resulting products can be readily converted into free vicinal diamines. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Formula: C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Formula: C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《An Activatable Lanthanide Luminescent Probe for Time-Gated Detection of Nitroreductase in Live Bacteria》 was written by Brennecke, Benjamin; Wang, Qinghua; Zhang, Qingyang; Hu, Hai-Yu; Nazare, Marc. Computed Properties of C5H11NO2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Herein we report the development of a turn-on lanthanide luminescent probe for time-gated detection of nitroreductases (NTRs) in live bacteria. The probe is activated through NTR-induced formation of the sensitizing carbostyril antenna and resulting energy transfer to the lanthanide center. This novel NTR-responsive trigger is virtually non-fluorescent in its inactivated form and features a large signal increase upon activation. We show that the probe is capable of selectively sensing NTR in lysates as well as in live bacteria of the ESKAPE family which are clin. highly relevant multiresistant pathogens responsible for the majority of hospital infections. The results suggest that our probe could be used to develop diagnostic tools for bacterial infections. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Computed Properties of C5H11NO2)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C5H11NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Low-temperature-curable and positive-type photosensitive polyimide with high mechanical strength, high resolution and good pot-life based on chain extendable poly(amic acid), thermal degradable crosslinker, chain extender, thermal base generator and photoacid generator》 was written by Yeh, Yao-Ming; Karapala, Vamsi Krishna; Ueda, Mitsuru; Hsu, Chain-Shu. Application In Synthesis of tert-Butyl carbamate And the article was included in Journal of Photopolymer Science and Technology in 2020. The article conveys some information:

A pos.-type photosensitive polyimide (PSPI) based on a chain extendable poly(amic acid) (PAA), a thermally degradable cross-linker 1,3,5-tris[(2-vinyloxy)ethoxy]benzene (TVEB), a photoacid generator (PAG) (5-propylsulfonyloxyimino-5H-thiophene-2-ylidene)-(2-methylphenyl)acetonitrile, a chain extender di-Ph isophthalate (DPI) and a thermal base generator (TBG) t-Bu 2,6-dimethylpiperidine-carboxylate has been developed. The PAA prepared from 3,3′,4,4′-biphenyltetracarboxylic dianhydride and 4,4′-oxydianiline was end-capped with di-tert-Bu dicarbonate, and undergoes a chain extending reaction during a curing stage to constitute a linear structure. This advancing PSPI exhibited high resolution of 3μm, good mech. properties, low residue content of cross-linker, low imidization temperature (250°C) catalyzed by TBG, preventing corrosion of Cu circuits due to neutralization of photogenerated acids with bases from TBG and the extended pot-life by using the chain extender with high hydrolytic stability, inducing a wide-ranging applicability. The results came from multiple reactions, including the reaction of tert-Butyl carbamate(cas: 4248-19-5Application In Synthesis of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Application In Synthesis of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Copper-catalyzed oxidative benzylic C(sp3)-H amination: direct synthesis of benzylic carbamates》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Liu, Shuai; Achou, Raphael; Boulanger, Coline; Pawar, Govind; Kumar, Nivesh; Lusseau, Jonathan; Robert, Frederic; Landais, Yannick. Related Products of 4248-19-5 The article mentions the following:

A new efficient strategy to access benzylic carbamates I (R1 = H, Ph, 1-Naph, 4-AcOC6H4, etc.; R2 = Me, i-Pr, CH2OAc, etc.; R = Me, Bn, t-Bu, etc.) through C-H activation is reported. The use of a catalytic amount of a Cu(I)/diimine ligand in combination with NFSI ((PhSO2)2NF) or Selectfluor hexafluorophosphate (F-TEDA-PF6) as oxidants and H2NCO2R (R = Me, Et, i-Pr, Bn, etc.) as an amine source directly leads to the C-N bond formation at the benzylic position. The mild reaction conditions and the broad substrate scope make this transformation a useful method for the late-stage incorporation of a ubiquitous carbamate fragment onto hydrocarbons.T. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Related Products of 4248-19-5)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Related Products of 4248-19-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2019,Journal of the American Chemical Society included an article by Boyington, Allyson J.; Seath, Ciaran P.; Zearfoss, Avery M.; Xu, Zihao; Jui, Nathan T.. Quality Control of tert-Butyl carbamate. The article was titled 《Catalytic Strategy for Regioselective Arylethylamine Synthesis》. The information in the text is summarized as follows:

A mild, modular, and practical catalytic system for the synthesis of the highly privileged phenethylamine pharmacophore is reported. Using a unique combination of organic catalysts to promote the transfer of electrons and hydrogen atoms, this system performs direct hydroarylation of vinyl amine derivatives with a wide range of aryl halides (including aryl chlorides). This general and highly chemoselective protocol delivers a broad range of arylethylamine products with complete regiocontrol. The utility of this process is highlighted by its scalability and the modular synthesis of an array of bioactive small mols. In the experiment, the researchers used many compounds, for example, tert-Butyl carbamate(cas: 4248-19-5Quality Control of tert-Butyl carbamate)

tert-Butyl carbamate(cas: 4248-19-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Quality Control of tert-Butyl carbamate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics