Category: 41841-16-1

Adding a certain compound to certain chemical reactions, such as: 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41841-16-1, Formula: C9H9BrO2

Step 1: Preparation of methyl 2-(4-bromophenyl)propanoate Methyl 2-(4-bromophenyl)acetate (220 mg) prepared in Step 1 of Example 1 was dissolved in dimethylformamide (3 mL), NaH (53 mg) was added thereto, and the mixture was stirred for 30 mins at room temperature. Iodomethane (0.14 mL) was added to the mixture which was heated to 50 C., followed by stirring for 2 hrs. The reaction mixture was cooled down to room temperature, and water and ethyl acetate were added to form an organic and an aqueous layer. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered and distilled under reduced pressure, and purified by Prep. TLC (n-Hex:EA=1:1) to obtain the title compound (200 mg). 1H NMR (300 MHz, DMSO-d6): delta 7.50 (d, 2H), 7.27 (d, 2H), 3.81 (q, 1H), 3.58 (s, 3H), 1.37 (d, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(4-bromophenyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; HANMI PHARMACEUTICAL CO., LTD.; Park, Chul Hyun; Kim, Won Jeoung; Jung, Young Hee; Kim, Nam Du; Chang, Young Kil; Kim, Maeng Sup; US2014/163226; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 41841-16-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of the methyl 2-bromophenylacetate (0.86 ml; 5.31 mmol) in dichloromethane (10.2 ml, 159 mmol) are added N- bromosuccinimide (1 .04 g, 5.84 mmol) and azobisisobutyronitrile (43.6 mg, 0.27 mmol) at room temperature and the mixture is stirred at 100 C for 16 h under argon atmosphere. The reaction mixture is cooled down to room temperature. The mixture is diluted with diethyl ether and filtered. The filtrate is evaporated to dryness. The oily residue containing solid succinimid is diluted with heptane and filtered again. The solvent is removed to afford methyl 2-bromo-2-(4-bromophenyl)acetate (1 .38 g, 4.56 mmol, 86 % of theory).

The chemical industry reduces the impact on the environment during synthesis Methyl 2-(4-bromophenyl)acetate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK PATENT GMBH; SCHRAUB, Martin; DOBELMANN-MARA, Lars; RIEDMUELLER, Stefan; (326 pag.)WO2018/149852; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C9H9BrO2

To a stirred solution of 100 g methyl-(4-bromophenyl)acetate(9, 0.436 mol) in 300 cm3 tetrahydrofuran, 95 g sodium methoxide (1.75 mol) was added at 0-5 C and maintained for 1 h. 80 g dimethyl carbonate (0.88 mol)was added at 0-5 C over a period of 2 h. The reaction mass was maintained at 25-30 C until the completion ofthe reaction (monitored by HPLC). After completion of the reaction, tetrahydrofuran was concentrated under reduced pressure at 45 C to obtain the syrup. The syrup was diluted in 500 cm3 water and the product was extracted in250 cm3 dichloromethane. The organic layer was concentrated under reduced pressure at 45 C to obtain the thick solution which was dissolved in 200 cm3 isopropyl alcoholat 70 C and maintained for 1 h. The solution was cooled to 0 C and maintained for 60 min. The obtained solid was filtered, washed with isopropyl alcohol, and dried at 50-55 C for 4-6 h to provide 10. Yield: 80 g; purity by HPLC: 99%; m.p.: 72-76 C. The spectral data of compound 10 were found to agree with the reported data [8].

The synthetic route of 41841-16-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jagtap, Kunal M.; Niphade, Navnath C.; Gaikwad, Chandrashekhar T.; Shinde, Gorakshanath B.; Toche, Raghunath B.; Joshi, Divyesh R.; Mathad, Vijayavitthal T.; Monatshefte fur Chemie; vol. 149; 3; (2018); p. 653 – 661;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 41841-16-1, The chemical industry reduces the impact on the environment during synthesis 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, I believe this compound will play a more active role in future production and life.

Methyl 2-(4-bromophenyl)acetate (1.00 g, 4.37 mmol)Dissolved in anhydrous DMF (12.5mL),The reaction solution is under N2 protection,Add NaH (700 mg, 17.5 mmol, 60%) at 0 C.Stir for about 15 minutes,CH3I (1.62 mL) was added slowly.After the dropwise addition was completed, the reaction solution was further stirred at 0 C for 15 minutes.Then transfer to room temperature for 12 h.After the reaction with saturated ammonium chloride (20mL) The reaction was quenched and extracted with EA (20mL), the organic layer was washed with saturated brine (30 mL), thenAfter concentration under reduced pressure,To give the title compound as a yellow oily substance (1.12g, 99.8%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(4-bromophenyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Xinchang; Ren Qingyun; Yan Guanghua; S ·geerdeman; Zhang Yingjun; (200 pag.)CN109678859; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41841-16-1, Product Details of 41841-16-1

At 40 C., a solution of intermediate B.i (52 g) in THF (100 mL) was carefully added over a period of 40 min to a suspension of NaH (15.6 g) in dry THF (450 mL). Stirring was continued for 70 min without heating and the temperature dropped to 27 C. The evolution of gas stopped before dimethylcarbonate (76.42 mL) was added dropwise while the temperature of the mixture was maintained at 29-31 C. Stirring was continued for 22 h at rt. The mixture was cooled to -10 C. and then carefully neutralized to pH 6-7 with aq. HCl before bulk of the THF was removed in vacuo. The residue was dissolved in EA (700 mL), washed 3 times with 1 N aq. HCl-solution and once with brine, dried over MgSO4. Most of the EA was evaporated before Hex was added. The product crystallised overnight at 4 C. The crystals were collected, washed with Hex and dried to give the expected product as pale yellow crystals (45.9 g).1H-NMR (D6-DMSO): delta 3.66 (s, 6H); 5.07 (s, 1H); 7.30-7.34 (m, 2H); 7.55-7.59 (m, 2H),

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Bolli, Martin; Boss, Christoph; Treiber, Alexander; US2012/142716; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 41841-16-1,Some common heterocyclic compound, 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of methyl 2-(4-bromophenyl)acetate (1 g, 4.36 mmol) in dry THF (20 mL)was added LiHMDS (5.23 mL, 1 M) dropwise at -78 C under N2. The mixture was stirred at 0C for 2 h. After Mel (1.23 g, 8.72 mmol) was added at -78 C, the mixture was stirred at 20 Cfor 16 h. Quenched with NH4C1 sat. and extracted with EtOAc. The organic was concentratedand purified by silica gel colunm (PE/EtOAc = 1/0 to 100/1) to give the title product (642 mg,yield 6 1%). MS (ES+) C10H11BrO2 requires: 243, found 244 [M+H].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-(4-bromophenyl)acetate, its application will become more common.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; BROOIJMANS, Natasja; BRUBAKER, Jason, D.; FLEMING, Paul, E.; HODOUS, Brian, L.; KIM, Joseph, L.; WAETZIG, Josh; WILLIAMS, Brett; WILSON, Douglas; WILSON, Kevin, J.; (347 pag.)WO2017/181117; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 41841-16-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41841-16-1 name is Methyl 2-(4-bromophenyl)acetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of Intermediate methyl 1-(4-bromoDhenyl)cvclobutanecarboxylate (1AH-1); Sodium hydride (3.5g, 88mmol) was stirred as a suspension in dimethylformamide (250ml) under argon. This was warmed to 35C and methyl 2-(4-bromophenyl)acetate (10g, 44mmol) in dimethylformamide (10OmL) was added drop wise over 1 hour and then stirred at 300C for 1 hour. To this the 1 ,3-dibromopropane (4.4ml, 44mmol) in dimtheylformamide (50ml) was added drop wise over 1 hour, and this was left to stir at room temperature overnight. The reaction was incomplete. Sodium hydride (3.5g, 88mmol) was prepared in dimethylformamide (100ml) at 35C and was added to this drop wise to the reaction mixture over 1 hour. This was again left to stir at room temperature overnight. Saturated aqueous ammonium chloride solution (200ml) was carefully added, followed by water (500ml). The product was extracted with ethyl acetate (2 x 500ml), washed with water (3 x 500ml), and brine (2 x 500ml). The organic solution was then dried over magnesium sulfate, filtered, and evaporated. The crude product was purified by flash chromatography (12.5% ethyl acetate in heptane)to methyl 1-(4-bromophenyl)cyclobutanecarboxylate (900mg, 3.3mmol, 7.5%).1 H NMR (400MHz CDCI3) 7.45 (d, 2H), 7.15 (d, 2H), 3.65 (s, 3H), 2.80 (m, 2H), 2.45 (m, 2H), 2.05 (m 1 H), 1.85 (m, 1 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-(4-bromophenyl)acetate, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; ASPNES, Gary, Erik; DOW, Robert, Lee; MUNCHHOF, Michael, John; WO2010/86820; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 41841-16-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Methyl 4-bromophenylacetate (0.9 g, 4.5 mmol) was dissolved in chloroform (30 mL).Add NBS (0.3g, 4.5mmol),Stir at 70 C for 2 hours.After the reaction solution is diluted, it is washed with water.The mixture was washed with saturated brine, dried over anhydrous sodium sulfate and evaporated.Purified by silica gel column chromatography,A colorless liquid (0.5 g, 38%) was obtained.

The synthetic route of Methyl 2-(4-bromophenyl)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanghai Xiangjin Biological Technology Co., Ltd.; Sun Fang; Zhan Youni; (53 pag.)CN108341814; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H9BrO2

To a suspension of sodium hydride (60% in oil, 192 mg, 4.80 mmol,) in DMF (11 mL) at 0 C was added methyl 2-(4-bromophenyl)acetate (0.35 mL, 2.2 mmol). The mixture was stirred for 15 minutes at 0 C and iodomethane (6.5 muL¡¤, 0.10 mmol) was added. The mixture was stirred for further 5 minutes at 0 C and at RT for 12 h, then quenched with 1 N aq. HCl (1 mL) and extracted with EtOAc (3 x 2 mL). The organic layer washed with H20 (3 x 2 mL) and brine (2 mL), dried over Na2S04, filtered and concentrated under reduced pressure. The residue was purified by Si02gel chromatography (0% to 5% EtOAc/Hexanes) to give methyl 2-(4- bromophenyl)-2-methylpropanoate (550 mg, 98%); MS (ES+) CgHgBrC^ requires: 228, found: 229/231 [M+H]+.

The synthetic route of 41841-16-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JONES, Philip; DIFRANCESCO, Maria, Emilia; PETROCCHI, Alessia; MARSZALEK, Joe; LIU, Gang; KANG, Zhijun; CARROLL, Christopher, L.; MCAFOOS, Timothy; CZAKO, Barbara; WO2014/31928; (2014); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 41841-16-1

A solution of methyl 2-(4-bromophenyl)acetate (6g, 30mmol) in tetrahydrofuran (67.2ml, 0.39/W) was added 1 M potassium t-butoxide in tetrahydrofuran (57.6ml, 57.6mmol). Reaction mixture was cooled to 00C and methyl iodide (3.59ml, 57.6mmol) was added drop wise. After addition was complete, reaction was slowly warmed up to room temperature and stirred for 16 hours. Reaction mixture was then carefully quenched with 1 M hydrochloric acid and concentrated. Reaction was diluted with water and extracted with ethyl acetate. Pooled organics were washed with water and brine and then dried over sodium sulfate, filtered and concentrated to give a crude dark oil. Crude product purified on silica gel eluting with 0%-5% ethyl acetate in heptane to give methyl 2-(4-bromophenyl)-2-methylpropanoate (1 D-1 ) (6.44g, 92%) as a yellow oil 1 H NMR (400 MHz, CHLOROFORM-d) d ppm 1.54 (s, 6 H) 3.63 (s, 3 H) 7.19 (d, J=8.78 Hz, 2 H) 7.43 (d, J=8.98 Hz, 2 H)MS(LC-MS) 371.2 (M+1 )

The synthetic route of 41841-16-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; ASPNES, Gary, Erik; DOW, Robert, Lee; MUNCHHOF, Michael, John; WO2010/86820; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics