Application of 41727-48-4,Some common heterocyclic compound, 41727-48-4, name is Methyl 4-amino-3,5-dichlorobenzoate, molecular formula is C8H7Cl2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3.12 g (0.078 mol) of sodium hydroxide was added to a solution of 10.33 g (0.039 mol) of methyl 4-amino-3,5-dichlorobenzoate in 40 mL of DMF, followed by addition of 10.37 g (0.039 mol) of 2,4,5,6-tetrachloroisophthalonitrile under stirring, the mixture was stirred for 5 h after addition at room temperature. After the reaction was over by Thin-Layer Chromatography monitoring, the reaction mixture was poured into water and extracted with ethyl acetate, the organic phase was washed with water and saturated brine, dried over anhydrous magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was purified through silica column (ethyl acetate/petroleum ether (boiling point range 60-90 C.)=1:4, as an eluent) to give 13.65 g of compound B-62 as yellowish solid, m.p. 229-231 C. [0147] 1H-NMR (300 MHz, internal standard TMS, solvent CDCl3) delta (ppm): 3.96 (s, 3H, CH3), 6.92 (s, 1H, NH), 8.11 (s, 2H, Ph-2,6-2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 4-amino-3,5-dichlorobenzoate, its application will become more common.
Reference:
Patent; SHENYANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD.; SINOCHEM CORPORATION; Liu, Changling; Huang, Guang; Lan, Jie; Hao, Shulin; Li, Zhinian; Li, Huichao; Guan, Aiying; Jiang, Airu; Xu, Ying; US2014/213598; (2014); A1;,
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