Total Synthesis of the Flavonoid Natural Product Houttuynoid A was written by Jian, Jie;Fan, Jilin;Yang, Hui;Lan, Ping;Li, Manmei;Liu, Peijun;Gao, Hao;Sun, Pinghua. And the article was included in Journal of Natural Products in 2018.Reference of 4163-60-4 This article mentions the following:
The first total synthesis of the antiviral flavonoid houttuynoid A (I) has been achieved from 2,4-bis(benzyloxy)-6-hydroxyacetophenone and a benzofuran aldehyde in nine linear steps. The C6-C3-C6 structure of the flavonoid was synthesized by an I2-catalyzed oxa-Michael addition of a chalcone intermediate, generated by Claisen-Schmidt condensation. This work provides a method for the synthesis of houttuynoids and provides a reference for the synthesis of the remaining members of the houttuynoid family. In the experiment, the researchers used many compounds, for example, (2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4Reference of 4163-60-4).
(2S,3R,4S,5S,6R)-6-(Acetoxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate (cas: 4163-60-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Reference of 4163-60-4
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics