Category: 41575-94-4

Application of 41575-94-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), is researched, Molecular C6H12N2O4Pt, CAS is 41575-94-4, about Intracranial complete response for non-small-cell lung cancer patient with negative PD-L1 expression of the lung using nivolumab. Author is Kitadai, Rui; Zenke, Yoshitaka; Hishima, Tsunekazu; Hosomi, Yukio.

Background : Nivolumab has shown promising results against non-small-cell lung cancer (NSCLC). However, its efficacy to treat central nervous system (CNS) metastases, specifically among programmed cell death 1 ligand 1 (PD-L1)-neg. patients, remains unclear. Case : A 66-yr-old woman was diagnosed with adenocarcinoma stage II and underwent a left lower lobectomy. The histopathol. evaluation revealed stage IVA with pleural dissemination. The patient did not harbor an epidermal growth factor receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) rearrangement, and PD-L1 expression of the surgical specimen using 22C3 assay was 0%. Single brain metastasis was detected, and carboplatin and nab-paclitaxel were administered. After three cycles, asymptomatic multiple brain metastases were identified, and the patient was treated with nivolumab as second-line chemotherapy. Six months later, MRI revealed an intracranial complete response (CR). Nivolumab was discontinued after 23 cycles due to immune-related adverse events (irAEs) of grade 2 rash. However, its effects were sustained for 13 mo after discontinuation. We were unable to evaluate the PD-L1 expression of brain metastases, which may show heterogeneity. Conclusion : This case demonstrates that nivolumab effectively treated a patient with neg. PD-L1 expression of the lung harboring CNS metastases.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Clinical Trial, Phase III, Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Gynecologic oncology called Prognostic significance of ethnicity and age in advanced stage epithelial ovarian cancer: An NRG oncology/gynecologic oncology group study., Author is duPont, Nefertiti C; Enserro, Danielle; Brady, Mark F; Moxley, Katherine; Walker, Joan L; Cosgrove, Casey; Bixel, Kristin; Tewari, Krishnansu S; Thaker, Premal; Wahner Hendrickson, Andrea E; Rubin, Stephen; Fujiwara, Keiichi; Casey, A Catherine; Soper, John; Burger, Robert A; Monk, Bradley J, which mentions a compound: 41575-94-4, SMILESS is O=C1C2(CCC2)C(O[Pt]O1)=O.N.N, Molecular C6H12N2O4Pt, Recommanded Product: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II).

BACKGROUND: Age and ethnicity are among several factors that influence overall survival (OS) in ovarian cancer. The study objective was to determine whether ethnicity and age were of prognostic significance in women enrolled in a clinical trial evaluating the addition of bevacizumab to front-line therapy. METHODS: Women with advanced stage ovarian, primary peritoneal, or fallopian tube cancer were enrolled in a phase III clinical trial. All women had surgical staging and received adjuvant chemotherapy with one of three regimens. Cox proportional hazards models were used to evaluate the relationship between OS with age and race/ethnicity among the study participants. RESULTS: One-thousand-eight-hundred-seventy-three women were enrolled in the study. There were 280 minority women and 328 women over the age of 70. Women age 70 and older had a 34% increase risk for death when compared to women under 60 (HR = 1.34; 95% CI 1.16-1.54). Non-Hispanic Black women had a 54% decreased risk of death with the addition of maintenance bevacizumab (HR = 0.46, 95% CI:0.26-0.83). Women of Asian descent had more hematologic grade 3 or greater adverse events and a 27% decrease risk of death when compared to non-Hispanic Whites (HR = 0.73; 95% CI: 0.59-0.90). CONCLUSIONS: Non-Hispanic Black women showed a decreased risk of death with the addition of bevacizumab and patients of Asian ancestry had a lower death rate than all other minority groups, but despite these clinically meaningful improvements there was no statistically significant difference in OS among the groups.

Here is a brief introduction to this compound(41575-94-4)Recommanded Product: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II), if you want to know about other compounds related to this compound(41575-94-4), you can read my other articles.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics