Category: 4131-74-2

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4131-74-2 as follows. HPLC of Formula: C8H14O4S

Methanol (360 kg) was added to a glass lining kettle, stirred and cooled. The kettle was cooled to 0-5C. Methylamine (180 kg) was introduced within a period of 3-4 hours. After the introduction, the mixture was stirred for 10 minutes while keeping warm. The resultant product was discharged and sealed for storage.; The compound of formula II prepared according to Example 2 and a reacting mother liquid comprising methylamine (35%) were continuously added to the reaction kettle K1 (50 L) from the bottom at a speed of 1 kg per minute and 3 kg per minute, respectively. The resultant product was cooled to the temperature of 0-8C with stirring. The reaction solution overflowing the upper part (5/6 of the total height) of the reaction kettle K1 flowed into the reaction kettle K2 (50 L) from the bottom. The resultant mixture was cooled to the temperature of 0-8C with stirring. The reaction solution overflowing the upper part (5/6 of the total height) of the reaction kettle K2 flowed into the kettles K3 and K4 in the same manner. The reaction solution overflowing the upper part (5/6 of the total height) of the reaction kettle K4 alternately flowed into the centrifuges N1 and N2 having a diameter of 300 mm at a flowing speed of 4 kg/minute for a solid-liquid separation. The mother liquid entered the reaction kettle P (50 L) (in which liquid methylamine was continuously added to the kettle from the bottom at a speed of 0.26 kg/minute). The resultant product was subsequently pumped into the reaction kettle K1. The solid entered the reaction kettles Q1 and Q2 (50 L). The resultant mixture was washed with approximately equal mass of methanol and was subjected to a solid-liquid separation via the centrifuges R1 and R2 (300 mm), respectively. The solid was dried and entered the storage tank T. The experiment was carried out for 20 hours to give 498 kg of the compound of formula V (98.5% via chromatography analysis).

According to the analysis of related databases, 4131-74-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Beijing Tianqing Chemicals Co., Ltd.; EP2216331; (2010); A1;,
Ester – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4131-74-2, name is Dimethyl 3,3-Thiodipropionate, A new synthetic method of this compound is introduced below., Recommanded Product: Dimethyl 3,3-Thiodipropionate

Preparation example 1: Methyl 4-oxotetrahydrothiopyrane-3-carboxylate A solution (100 ml) of dimethyl 3,3′-thiodipropionate (8.25 g) in anhydrous tetrahydrofuran was added with sodium hydride (2.11 g) and heated under reflux for 5 hours. The reaction mixture was cooled, then added with acetic acid (8 ml), poured into water, and extracted with ether. The organic layer was dried over anhydrous magnesium sulfate and then evaporated under reduced pressure to obtain the above-titled product.

The synthetic route of 4131-74-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Meiji Seika Kaisha, Ltd.; EP1142881; (2001); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

4131-74-2, name is Dimethyl 3,3-Thiodipropionate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Dimethyl 3,3-Thiodipropionate

2.7098 g of NaH (60%) was added to 250 ml of dry three-necked flask,40 ml of anhydrous tetrahydrofuran (THF) was added,Stirred at room temperature for 10 min,A solution of dimethyl 3,3′-thiodipropionate (10.1015 g)In THF (30 ml) was added and heated to reflux,About 1h drops finished,After adding 10mlTHF rinse the dropping funnel,Continue to return after 1h,The reaction was stopped and allowed to cool to room temperature.The reaction solution was adjusted to a pH of 6 to 7 with 2% dilute hydrochloric acid and then extracted with dichloromethane (30 ml * 3)The layers were washed with saturated sodium chloride solution and the organic layer was collected and washed with sufficient anhydrous sodium sulfate and filtered. The filtrate was filteredThe solvent was removed by evaporation to give 7.5639 g of a yellow oily liquid,4-oxo-tetrahydro-2H-thiopyran-3-carboxylic acid methyl ester (II)Yield 88.7%.

The synthetic route of 4131-74-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Sun Chengyu; Tang Qidong; Chen Chen; Lei Fei; Wu Chunjiang; Tu Yuanbiao; Ouyang Yiqiang; (42 pag.)CN105153190; (2017); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4131-74-2, name is Dimethyl 3,3-Thiodipropionate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 4131-74-2

Chemistry The preparation of target compounds 9-28 was described in Schemes 1 and 2. Compounds 7a-d and 8a-e were synthesized according to the procedures reported previously by our group [18,19]. The different substituent of phenylamine reacted with triphosgene to get compound compounds 7a-d. 8a-e was synthesized from the different substituent of chlorobenzene through three steps. The key intermediates 4-(2-chloro-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-yl)morpholine (4a) and 2-chloro-4-morpholino-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine 6,6-dioxide(4b) were synthesized according to the procedures reported previously by our group

The synthetic route of 4131-74-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lei, Fei; Sun, Chengyu; Xu, Shan; Wang, Qinqin; Ouyang, Yiqiang; Chen, Chen; Xia, Hui; Wang, Linxiao; Zheng, Pengwu; Zhu, Wufu; European Journal of Medicinal Chemistry; vol. 116; (2016); p. 27 – 35;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

4131-74-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4131-74-2 as follows.

26.16g (0.1411 mol) of octadecylamine was added to a 250 ml reaction flask, followed by addition of 100ml of high-boiling petroleum ether (90-120 C) or toluene or ethanol, 1-10% (molar ratio) of p-toluenesulfonic acid or hydrochloric acid or acetic acid or hydrochloric acid and 10g (0.04848 mol) of intermediate of product V. Placed in a constant temperature oil bath pot and stirred the reaction temperature was set at 125 , nitrogen protection plus condensate trap. (Time to complete the reaction time is about 36-48 hours, with increasing temperature the reaction flask to dissolve the solid into a liquid, when the end of the reaction, the flask was cooled to room temperature, the liquid into a solid whole. To the reaction flask with stirring adding an appropriate amount of methanol, and then subjected to suction filtration, washed with methanol 2-4 times, after heating to 40 degrees Celsius drained and dried under vacuum to give a white solid, yield 86-97%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4131-74-2, and friends who are interested can also refer to it.

Reference:
Patent; Shaoxing Ruikang Biotechnologies Co., Inc.; Mao, Lijuan; Liu, Shubai; Wang, Songping; Zhang, Zaixian; Wan, Dingfei; Peng, Chuanyang; Ding, Yifan; Sun, Xing; (21 pag.)CN105693545; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics