Category: 41191-92-8

Cornea, Felicia et al. published their research in Revue Roumaine de Chimie in 1980 | CAS: 41191-92-8

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C10H13NO2

Potential anticancer agents. XXI. Synthesis and biological evaluation of some new triazene derivatives was written by Cornea, Felicia;Ionescu, D.;Zglobiu, Mariana;Botez, Georgeta;Dobre, V.;Niculescu-Duvaz, I.. And the article was included in Revue Roumaine de Chimie in 1980.Computed Properties of C10H13NO2 This article mentions the following:

Triazenes I (R = OH, alkoxy, OPh, amino, amino acid residue) (36 compounds) were prepared by diazotizing the amines and reaction with Me2NH. Some I showed moderate activity against Walker 256 carcinosarcoma. II was similarly prepared and gave an increased life span of 35% in leukemia L1210-infected mice. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8Computed Properties of C10H13NO2).

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Computed Properties of C10H13NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mei, Yousheng et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 41191-92-8

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of Ethyl 3-amino-4-methylbenzoate

Synthesis of substituted 2-alkylquinolines by visible-light photoredox catalysis was written by Mei, Yousheng;Liu, Jie;Wang, Lei;Li, Pinhua. And the article was included in Organic & Biomolecular Chemistry in 2020.Safety of Ethyl 3-amino-4-methylbenzoate This article mentions the following:

The condensation of anilines RNH2 (R = 2-methyl-4-chlorophenyl, 4-chlorophenyl, 2-methoxyphenyl, etc.) and alkenyl ethers such as ethoxyethene, (E)-1-ethoxyprop-1-ene, (E)-1-ethoxybut-1-ene has been demonstrated by employing visible-light photoredox catalysis. The resulting method enables the synthesis of substituted 2-alkylquinolines I [R1 = Me, Et, Pr; R2 = H, Me, Et; R3 = H, I, Br, etc.; R4 = CN, COOMe, Me, etc.; R5 = H, Br, Me, etc.], II (R6 = H, CF3, Et, OMe; R7 = H, Cl, Br) under mild and simple conditions with good substrate scope and high yields. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8Safety of Ethyl 3-amino-4-methylbenzoate).

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Safety of Ethyl 3-amino-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Yongjiang et al. published their research in Zhongguo Yiyao Gongye Zazhi in 2009 | CAS: 41191-92-8

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C10H13NO2

Synthesis of nilotinib was written by Chen, Yongjiang;Wang, Lihua;Zhou, Hong;Wang, Congzhan. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2009.Electric Literature of C10H13NO2 This article mentions the following:

The 5-bromo-3-(trifluoromethyl) phenylamine was reacted with 4-methyl-1H-imidazole in presence of cesium carbonate and cuprous iodide to obtain 3-trifluoromethyl-5-(4-methyl-1H-imidazol-1-yl) phenylamine. Et 3-amino-4-Me benzoate was reacted with cyanamide to obtain the guanidine 6, which cyclized with 3-dimethylamino-1-(3-pyridinyl)-2-propylene-1-one to provide Et 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoate. Et 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoate was subjected to Boc protection, hydrolysis, amidation and then condensation with 3-trifluoromethyl-5-(4-methyl-1H-imidazol-1-yl) phenylamine to give 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl) phenyl]-3-[N-tert-butoxycarbonyl-[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzamide. After deprotection, the antitumor agent nilotinib (I) was obtained with an overall yield of 40%. In the experiment, the researchers used many compounds, for example, Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8Electric Literature of C10H13NO2).

Ethyl 3-amino-4-methylbenzoate (cas: 41191-92-8) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C10H13NO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sources of common compounds: Ethyl 3-amino-4-methylbenzoate

These common heterocyclic compound, 41191-92-8, name is Ethyl 3-amino-4-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Ethyl 3-amino-4-methylbenzoate

These common heterocyclic compound, 41191-92-8, name is Ethyl 3-amino-4-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Ethyl 3-amino-4-methylbenzoate

EXAMPLE 14 Ethyl 3-[[(5,6-dihydro-2-methyl-1,4-oxathiin-3-yl) carbonyl]amino]-4-methylbenzoate (Compound 14) Thionyl chloride (4.5 g, 0.038 mole) was added to a stirred mixture of 5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxylic acid (6.0 g, 0.037 mole) and methylene chloride (100 ml. The mixture was warmed to 30-35 C. for 3 hours, then evaporated under reduced pressure. The residue, crude 5,6-dihydro-2-methyl-1,4-oxathiin-3-carbonyl chloride, was dissolved in methylene chloride (100 ml), and the ice-chilled solution treated dropwise with a solution of ethyl 3-amino-4-methylbenzoate (6.7 g, 0.037 mole) and triethylamine (4.0 g, 0.040 mole) in methylene chloride (100 ml). The reaction mixture was stirred overnight at room temperature and then worked up by washing in sequence with water, dilute hydrochloric acid, water, 2% sodium hydroxide and water. Evaporation of the solvent gave an oil, which solidified. After recrystallization from ethanol (30 ml), the product (7.1 g, 59% yield) melted at 105-107 C. Analysis: Calc.: C 59.79, H 5.96, N 4.36, Found: C 59.87, H 5.73, N 4.52 NMR: (CDCl3): 1.35 (3H,t), 2.25 (3H,s), 2.3 (3H,s) 2.3 (3H,s), 3.0 (2H,m), 4.15-4.55 (4H,m), 7.1-7.3 (1H,m), 7.55-7.95 (2H,m), 8.45 (1H,d)

The synthetic route of Ethyl 3-amino-4-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Uniroyal Chemical Company, Inc.; Uniroyal Chemical Ltd./Ltee; US5268389; (1993); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics