Category: 40637-56-7

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40637-56-7, name is Dimethyl 2-allylmalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C8H12O4

According to a reported procedure,18 a solution of dimethyl 2-allylmalonate (19) (1.77 mL, 11.0mmol, 1.0 equiv) in Et2O (25 mL) was added dropwise to a suspension of LiAlH4 (1.25 g, 33.0mmol, 3.0 equiv) in Et2O (31 mL) at 0C. The resulting mixture was stirred at room temperature for3 h; it was then cooled back to 0C and the reaction was quenched by slow addition of water (1.05mL). The mixture was allowed to warm to rt and treated with aqueous NaOH (15%, 1.05 mL) andwater (3.2 mL). The resulting white slurry was filtered through Celite and then washed with EtOAc(4 x 50 mL). After removal of the solvent by distillation under reduced pressure, the crude productwas purified by column chromatography (SiO2, eluting with Et2O) to afford diol 20 as a colorlessoil (744 mg, 6.40 mmol, 58% yield). Following a reported procedure,19 a solution of diol 20 (581 mg, 5.00 mmol, 1.0 equiv) in THF (4.0mL) was added dropwise to a suspension of NaH (60% dispersion in mineral oil, 120 mg, 5.00mmol, 1.0 equiv) in THF (10 mL). The mixture was stirred at rt for 50 min and then a solution oftriisopropyl silyl chloride (0.96 mL, 4.5 mmol, 0.9 equiv) in THF (4.0 mL) was slowly added. Afterstirring for 2 h, the reaction was quenched by treatment with aqueous K2CO3 (1.0 M, 15 mL). Theaqueous layer was separated from the organic one and extracted with Et2O (3 x 15 mL). Thecombined organic layers were washed with brine (15 mL), dried over MgSO4, filtered and thesolvent was removed in vacuo. Purification by column chromatography (SiO2, eluting with 95:5pentane:EtOAc) afforded the monoprotected diol 21 as a colorless oil (1.15 g, 4.23 mmol, 85%yield).

The synthetic route of 40637-56-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nicolai, Stefano; Swallow, Peter; Waser, Jerome; Tetrahedron; vol. 71; 35; (2015); p. 5959 – 5964;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40637-56-7, name is Dimethyl 2-allylmalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Dimethyl 2-allylmalonate

A typical procedure for the iodine(III) reagent-induced anti-Markovnikov hydroazidation of unactivated alkenes: to asolution of 4-phenyl-1-butene (1a) (0.030 mL, 0.2 mmol)and ABX-N3 (11.6 mg, 0.04 mmol) in dichloromethane(DCM) (0.2 mL), TMSN3 (0.052 mL, 0.4 mmol) and HOAc(0.024 mL, 0.4 mmol) were added under an argon atmosphereat room temperature. The reaction mixture was thenstirred for 4 h and monitored by thin layer chromatography(TLC) until 1a was completely consumed. After that, theaqueous of NaOH was added to quench extra HN3 [18], andthe mixture was extracted by Et2O for two times. The organiclayer was dried over MgSO4, filtered and concentrated undervacuum. The residue was purified by flash column chromatography(petroleum ether/ethyl acetate, 20:1 to 10:1) togive product 2a in 83% yield.

The synthetic route of 40637-56-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Li, Xiaonan; Chen, Pinhong; Liu, Guosheng; Science China Chemistry; vol. 62; 11; (2019); p. 1537 – 1541;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40637-56-7, name is Dimethyl 2-allylmalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 40637-56-7

According to a reported procedure,18 a solution of dimethyl 2-allylmalonate (19) (1.77 mL, 11.0mmol, 1.0 equiv) in Et2O (25 mL) was added dropwise to a suspension of LiAlH4 (1.25 g, 33.0mmol, 3.0 equiv) in Et2O (31 mL) at 0C. The resulting mixture was stirred at room temperature for3 h; it was then cooled back to 0C and the reaction was quenched by slow addition of water (1.05mL). The mixture was allowed to warm to rt and treated with aqueous NaOH (15%, 1.05 mL) andwater (3.2 mL). The resulting white slurry was filtered through Celite and then washed with EtOAc(4 x 50 mL). After removal of the solvent by distillation under reduced pressure, the crude productwas purified by column chromatography (SiO2, eluting with Et2O) to afford diol 20 as a colorlessoil (744 mg, 6.40 mmol, 58% yield). Following a reported procedure,19 a solution of diol 20 (581 mg, 5.00 mmol, 1.0 equiv) in THF (4.0mL) was added dropwise to a suspension of NaH (60% dispersion in mineral oil, 120 mg, 5.00mmol, 1.0 equiv) in THF (10 mL). The mixture was stirred at rt for 50 min and then a solution oftriisopropyl silyl chloride (0.96 mL, 4.5 mmol, 0.9 equiv) in THF (4.0 mL) was slowly added. Afterstirring for 2 h, the reaction was quenched by treatment with aqueous K2CO3 (1.0 M, 15 mL). Theaqueous layer was separated from the organic one and extracted with Et2O (3 x 15 mL). Thecombined organic layers were washed with brine (15 mL), dried over MgSO4, filtered and thesolvent was removed in vacuo. Purification by column chromatography (SiO2, eluting with 95:5pentane:EtOAc) afforded the monoprotected diol 21 as a colorless oil (1.15 g, 4.23 mmol, 85%yield).

The synthetic route of 40637-56-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Nicolai, Stefano; Swallow, Peter; Waser, Jerome; Tetrahedron; vol. 71; 35; (2015); p. 5959 – 5964;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40637-56-7, name is Dimethyl 2-allylmalonate, A new synthetic method of this compound is introduced below., Application In Synthesis of Dimethyl 2-allylmalonate

General procedure: A 50 mL Schlenk tube containing NaH (60% in mineral oil, 240 mg, 6 mmol)was evacuated and filled with argon (3x). THF (10 mL) was added and thesuspension was cooled in ice/water bath. Appropriately substituted dimethyl(allyl)malonate (5 mmol) was added dropwise (caution, hydrogen evolution),then cooling bath was removed and the reaction mixture was stirred at rt for 30min. Then substituted propargil bromide or methanesulfonate (6 mmol) wasadded and the reaction mixture was stirred at rt for 1h. The mixture wasquenched with NH4Cl(aq.) (20 mL) and extracted with MTBE (3 × 20 mL). Combined organic extractswere dried (Na2SO4), concentrated and crude product was purified by column chromatography onsilica gel (50 g column, 98:2 ? 95:5 hexanes/EtOAc).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kocoj, Ma?gorzata; Jarosi?ska, El?bieta; Cha?adaj, Wojciech; Synlett; vol. 29; 10; (2018); p. 1319 – 1323;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40637-56-7, name is Dimethyl 2-allylmalonate, A new synthetic method of this compound is introduced below., COA of Formula: C8H12O4

4.1.1 2-Allyl-2-methoxycarbonyl-malonic acid dimethyl ester (5) 13 At 0 C, to a suspension of NaH (60% in mineral oil) (5.85 g, 146.2 mmol, 1.5 equiv) in THF (150 mL), was added 4 (16.78 g, 97.4 mmol) and the mixture was warmed to rt and stirred during 1 h. Then, freshly distilled ClCO2Me (20 mL, 258.0 mmol, 2.6 equiv) was slowly added at 0 C and the solution was warmed to rt and stirred during 2 h. The reaction mixture was diluted in diethyl ether and washed with saturated aqueous solution of ammonium chloride and brine, dried over MgSO4, filtered, and concentrated. Pure compound 5 (20.41 g, 88.6 mmol, 91%) was obtained as a colorless oil. 1H NMR (CDCl3, 200 MHz) delta 5.95-5.77 (ddt, J=17.2; 10.3 and 7.4 Hz, 1H, H2C=CHCH2); 5.09 (dd, J=17.2 and 1 Hz, 1H, HC=CHtrans); 4.99 (dd; J=10.3 and 1 Hz, 1H, HC=CHcis); 3.70 (s, 9H, CO2CH3); 2.78 (d, J=7.4 Hz, 2H, H2C=CHCH2). 13C NMR (CDCl3, 50 MHz) delta 166.9 (CO2CH3); 132.4 (H2C=CHCH2); 119.4 (H2C=CHCH2); 65.7 (C(CO2CH3)3); 53.1 (CO2CH3); 37.6 (H2C=CHCH2). IR (neat), cm-1: 2900; 1740; 1460; 1370; 1230. Anal. for C10H14O6 (M=230.22 g mol-1): calcd (%) : C=52.17; H=6.13. found (%) : C=52.06; H=6.32.

The synthetic route of 40637-56-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Agarwal, Jyoti; Commandeur, Claude; Malacria, Max; Thorimbert, Serge; Tetrahedron; vol. 69; 45; (2013); p. 9398 – 9405;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics