Category: 403-33-8

Category: esters-buliding-blocksIn 2021 ,《Illuminating Stannylation》 was published in Journal of the American Chemical Society. The article was written by Sakamoto, Kyoka; Nagashima, Yuki; Wang, Chao; Miyamoto, Kazunori; Tanaka, Ken; Uchiyama, Masanobu. The article contains the following contents:

Authors have developed photoboosted stannylation reactions of terminal alkynes (linear-selective hydrostannylation) and fluoroarenes (defluorostannylation), in which the stannyl anion is photoexcited to an excited triplet (T1) stannyl diradical species. This unprecedented T1-stannyl diradical species shows completely different reactivity and selectivity from those of stannyl anions and stannyl radicals. This methodol. is operationally simple, has broad functional group tolerance, and proceeds in high yield without the need for any catalyst. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Category: esters-buliding-blocks)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents》 was written by Zheng, Xian-Jing; Li, Chun-Shi; Cui, Ming-Yue; Song, Ze-Wen; Bai, Xue-Qian; Liang, Cheng-Wu; Wang, Hui-Yan; Zhang, Tian-Yi. Name: Methyl 4-fluorobenzoate And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

Twenty benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety were synthesized and evaluated for their antioxidant and antiinflammatory activities. Among these compounds, 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole and 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)-2-methoxyphenoxy)methyl)-5-(2-chlorophenyl)-1,3,4-oxadiazole were appeared to have high radical scavenging efficacies as 0.05 ± 0.02 and 0.07 ± 0.03 mmol/L of IC50 values in ABTS+· bioassay, resp. In antiinflammatory tests, compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole displayed good activity with 57.35% inhibition after i.p. administration, which was more potent than the reference drug (indomethacin). Mol. modeling studies were performed to study the binding mode of the representative compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole into COX-2 enzyme. In vitro enzyme study implied that compound 2-((4-((2-(Benzo[d]thiazol-2-yl)hydrazono)methyl)phenoxy)methyl)-5-(m-tolyl)-1,3,4-oxadiazole exerted its antiinflammatory activity through COX-2 inhibition. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Kumdale, Prashant Ganpatrao; Shitole, Nana Vikram published an article in Oriental Journal of Chemistry. The title of the article was 《Synthesis of pyrazole compounds by using sonication method》.Safety of Methyl 4-fluorobenzoate The author mentioned the following in the article:

A simple method for the synthesis of pyrazoles derivatives carried out by cyclization of cyanides with hydrazine hydrate by using sonication method. All the prepared compounds were characterized by 1H, 13C NMR and IR spectroscopy. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Safety of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Safety of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cheshmedzhieva, Diana; Ilieva, Sonia; Hadjieva, Boriana; Galabov, Boris published their research in Journal of Physical Organic Chemistry in 2021. The article was titled 《Hydrogen bonding probes electron density variations at the basic center in substituted alkyl benzoates: Theory and experiment》.Recommanded Product: Methyl 4-fluorobenzoate The article contains the following contents:

Theor. computations of charge d. parameters are juxtaposed to exptl. spectroscopic shifts induced by hydrogen bonding for a series of 21 substituted in the aromatic ring Et and Me benzoates. Strong correlations between at. charges at the proton accepting atom and the shifts of methanol O-H frequencies are established. Hirshfeld, Charge Model 5 (CM5), and natural population anal. (NPA) at. charges are evaluated using ωB97X-D/6-311++G(3df,2pd) and MP2/6-311++G(3df,2pd) computations. The results obtained reveal the power of hydrogen bond measurements in characterizing the variations of electron densities at the proton accepting center within a series of structurally related mols. The limits of application of the approach are outlined. The experimental process involved the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Dan; Li, Jianfeng; Li, Boyang; Zhao, Huacheng; Zhu, Hanghang; Kou, Jinfang; Zhang, Fengwei; Dong, Zhengping; Ma, Jiantai published an article in 2022. The article was titled 《Selective oxidation of alcohols to high value-added carbonyl compounds using air over Co-Co3O4@NC catalysts》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Reference of Methyl 4-fluorobenzoate The information in the text is summarized as follows:

The sustainable catalytic transformation of alcs. to high value-added fine chems. is a significant and challenging research topic. Herein, a set of nitrogen-doped carbon encapsulated Co-based catalysts (Co-Co3O4@NC-T) were prepared by using low-cost dicyandiamide, glyoxal and cobalt nitrate as precursors. The obtained catalysts were utilized for the selective oxidation of alcs. to high value-added esters and carboxylic acids with air as the oxygen source and displayed wide applicability for the oxidation of both aromatic and aliphatic alcs. Based on the controlled experiments, the protective effect of N-doped carbon structure and the synergistic effect between Co core and Co3O4 species guaranteed the high reaction conversion and selectivity. Benefitting from heterogeneity and magnetism of the catalyst, it can be easily recycled and reused for long-term stability. Reasonable mechanisms of selective oxidation reaction were proposed through EPR anal. and controlled experiments The present work provides a facile strategy for potential large-scale preparation of heterogeneous catalyst for sustainable and green catalytic transformations. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Reference of Methyl 4-fluorobenzoate) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Reference of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Copper-mediated tandem ring-opening/cyclization reactions of cyclopropanols with aryldiazonium salts: synthesis of N-arylpyrazoles》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Liu, Jidan; Xu, Erjie; Jiang, Jinyuan; Huang, Zeng; Zheng, Liyao; Liu, Zhao-Qing. Name: Methyl 4-fluorobenzoate The article mentions the following:

A general method for the synthesis of structurally diverse N-arylpyrazoles I [R = H, 3-Me, 4-Cl, etc.; R1 = c-Pr, Ph, 3-thienyl, etc.; R2 = H, Me, Et, etc.] from readily available cyclopropanols and aryldiazonium salts was disclosed. The reaction was conducted at room temperature within minutes with a broad substrate scope and excellent regioselectivity. In the experiment, the researchers used Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Name: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors via fragment-based virtual screening》 was written by Liu, Jian; Wen, Yu; Gao, Lina; Gao, Liang; He, Fengjun; Zhou, Jingxian; Wang, Junwei; Dai, Rupeng; Chen, Xiaojing; Kang, Di; Hu, Lihong. Related Products of 403-33-8 And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. The article conveys some information:

Fibroblast growth-factor receptor (FGFR) is a potential target for cancer therapy. We designed three novel series of FGFR1 inhibitors bearing indazole, benzothiazole, and 1H-1,2,4-triazole scaffold via fragment-based virtual screening. All the newly synthesized compounds were evaluated in vitro for their inhibitory activities against FGFR1. Compound 9d (I) bearing an indazole scaffold was first identified as a hit compound, with excellent kinase inhibitory activity (IC50 = 15.0 nM) and modest anti-proliferative activity (IC50 = 785.8 nM). Through two rounds of optimization, the indazole derivative 9u (II) stood out as the most potent FGFR1 inhibitors with the best enzyme inhibitory activity (IC50 = 3.3 nM) and cellular activity (IC50 = 468.2 nM). Moreover, II also exhibited good kinase selectivity. In addition, mol. docking study was performed to investigate the binding mode between target compounds and FGFR1. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Related Products of 403-33-8) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Related Products of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Guo, Xuewen; Unglaube, Felix; Kragl, Udo; Mejia, Esteban published an article in 2022. The article was titled 《B(C6F5)3-Catalyzed transfer hydrogenation of esters and organic carbonates towards alcohols with ammonia borane》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Recommanded Product: Methyl 4-fluorobenzoate The information in the text is summarized as follows:

Herein, authors report an efficient metal-free system for the transfer hydrogenation of esters and carbonates by-passing the otherwise ubiquitous formation of transesterification side-products. The Lewis acid B(C6F5)3 is used as catalyst and ammonia borane as hydrogen donor. This methodol. shows broad substrate scope and functional group tolerance in excellent yields at very mild conditions. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Shaolei; He, Zhi-Juan; Zhang, Ling-Hui; Huang, Bo-Lun; Chen, Xiao-Wei; Zhan, Zong-Song; Zhang, Fu-Min published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters》.Related Products of 403-33-8 The article contains the following contents:

Com. available cinchona alkaloids that can catalyze the enantiodivergent fluorination of β-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable. In the experiment, the researchers used Methyl 4-fluorobenzoate(cas: 403-33-8Related Products of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Related Products of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Cobalt-catalysed selective synthesis of aldehydes and alcohols from esters》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Pattanaik, Sandip; Gunanathan, Chidambaram. COA of Formula: C8H7FO2 The article mentions the following:

Efficient and selective reduction of esters R1COOR2 (R1 = n-pentyl, Ph, 4-MeC6H4, etc.; R2 = Me, Et, n-Bu, Bn) to aldehydes R1CHO (R1 = Ph, 4-MeC6H4, Bn, etc.) and alcs. R1CH2OH (R1 = Ph, 4-FC6H4, 4-MeC6H4, etc.) is reported in which a simple cobalt pincer catalyst catalyzes both transformations using diethylsilane as a reductant. Remarkably, the reaction selectivity is controlled by the stoichiometry of diethylsilane. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8COA of Formula: C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.COA of Formula: C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics