Category: 403-33-8

Toriumi, Naoyuki; Yamashita, Kazuya; Iwasawa, Nobuharu published an article in 2021. The article was titled 《Metal-Free Photoredox-Catalyzed Hydrodefluorination of Fluoroarenes Utilizing Amide Solvent as Reductant》, and you may find the article in Chemistry – A European Journal.COA of Formula: C8H7FO2 The information in the text is summarized as follows:

A metal-free photoredox-catalyzed hydrodefluorination of fluoroarenes was achieved by using N,N,N’,N’-tetramethyl-para-phenylenediamine as a strong photoreduction catalyst. This reaction was applicable not only to electron-rich monofluoroarenes but also to polyfluoroarenes to afford non-fluorinated arenes. The exptl. mechanistic studies indicated that the amide solvent NMP plays an important role for regeneration of the photocatalyst, enabling additive-free photoreduction catalysis. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8COA of Formula: C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.COA of Formula: C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Metal-Free Direct C-H β-Carbonyl Alkylation of Heteroarenes with Cyclopropanols Mediated by K2S2O8》 was written by Liu, Qiang; Wang, Qiang; Xie, Guanqun; Fang, Zeyang; Ding, Shujiang; Wang, Xiaoxia. Name: Methyl 4-fluorobenzoate And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

Direct C-H β-carbonyl alkylation of heteroarenes under metal-, acid- and photo-catalyst free conditions has been achieved. A wide scope of substrates, such as various substituted quinolines and isoquinolines, pyridines, pyridazine, benzo[d]thiazole and phenanthroline, underwent the β-carbonyl alkylation efficiently via K2S2O8-mediated ring-opening of cyclopropanols. The corresponding β-heteroarylated ketones were obtained in moderate to excellent yields and gram-scale experiments further demonstrated the practicality of this synthetic protocol. The readily available reagents, mild and environmentally benign conditions make the method extremely attractive. The reaction mechanism is also proposed. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Sadhu, Milon M.; Ray, Sumit K.; Unhale, Rajshekhar A.; Singh, Vinod K. published an article in Organic & Biomolecular Chemistry. The title of the article was 《Bronsted acid-catalyzed enantioselective addition of 1,3-diones to in situ generated N-acyl ketimines》.Formula: C8H7FO2 The author mentioned the following in the article:

A Bronsted acid-catalyzed asym. Mannich-type addition of 1,3-diones to cyclic N-acyl ketimines is reported for the synthesis of enantioenriched isoindolinones. Various dicarbonyl-substituted isoindolinones bearing a quaternary carbon stereocenter were synthesized with excellent yields (up to 98%) and moderate to high enantioselectivities (up to 95% ee), and most of them possess a fluorine atom at the reactive center. Furthermore, the synthetic utility of the protocol has been demonstrated by the debenzoylation of the product. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Formula: C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Formula: C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 403-33-8In 2021 ,《Super hydride catalyzed ester and isocyanate hydroboration》 was published in Journal of Organometallic Chemistry. The article was written by Du, Zonggang; Behera, Bedabyas; Kumar, Arun; Ding, Yi. The article contains the following contents:

Com. available, eco-friendly Li triethylborohydride (LiHBEt3, Super hydride) is an excellent catalyst for the solvent-free hydroboration of esters using pinacolborane at ambient reaction conditions. This was achieved with a low catalyst loading of 0.1 mol%. The protocol was further extended to the hydroboration of isocyanates with different stoichiometries, which displayed a clear chemo-selective catalytic activity towards the cleavage of C:N and C:O bonds. Compared with the previously reported catalysts, LiHBEt3 catalyzes in a short reaction time with solvent free conditions to provide nearly quant. products. The experimental process involved the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《One-step Conversion of Amides and Esters to Acid Chlorides with PCl3》 was written by Li, Fangshao; Wu, Xiaofang; Guo, Fengzhe; Tang, Zi-Long; Xiao, Jing. Synthetic Route of C8H7FO2 And the article was included in European Journal of Organic Chemistry in 2021. The article conveys some information:

A general and efficient iodine-promoted chlorination of amides RC(O)NR1R2 [R = Ph, 4-MeC6H4, 4-FC6H4, etc.; R1 = R2 = Me, n-Bu; R1 = H, Me, Ph; R3 = Ph] and esters RC(O)OMe [R = Ph, 4-MeC6H4, 4-BrC6H4, etc.] with phosphorus trichloride was described. For the first time various inactivated amides including secondary and tertiary amides were directly converted to the corresponding acid chlorides in one-step. The substrate scope of Me esters including aromatic and aliphatic esters was also explored under this system. This method was simple, scalable and wide in scope, which provided an approach to preparation of these acid chlorides. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Synthetic Route of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Synthetic Route of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rashed, Nurnobi Md.; Masuda, Koichiro; Ichitsuka, Tomohiro; Koumura, Nagatoshi; Sato, Kazuhiko; Kobayashi, Shu published their research in Advanced Synthesis & Catalysis in 2021. The article was titled 《Zirconium Oxide-Catalyzed Direct Amidation of Unactivated Esters under Continuous-Flow Conditions》.Quality Control of Methyl 4-fluorobenzoate The article contains the following contents:

A sustainable and environmentally benign direct amidation reaction of unactivated esters with amines was developed in a continuous-flow system. A com. available amorphous zirconium oxide was found to be an efficient catalyst for this reaction. While the typical amidation of esters with amines required a stoichiometric amount of a promoter or metal activator, the present continuous-flow method enabled the direct amidation reaction under additive-free conditions with an extensive diversity towards various functional groups. High yields of the products were obtained with a nearly equimolar proportion of starting materials to reduce byproduct formation, which rendered this process applicable for use in a sequential-flow system. The experimental process involved the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Quality Control of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Quality Control of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Ji, Jin; Shao, Wu-Bin; Chu, Pan-Long; Xiang, Hong-Mei; Qi, Pu-Ying; Zhou, Xiang; Wang, Pei-Yi; Yang, Song published an article in Journal of Agricultural and Food Chemistry. The title of the article was 《1,3,4-Oxadiazole Derivatives as Plant Activators for Controlling Plant Viral Diseases: Preparation and Assessment of the Effect of Auxiliaries》.Recommanded Product: 403-33-8 The author mentioned the following in the article:

Plant viral diseases cause the loss of millions of dollars to agriculture around the world annually. Therefore, the development of highly efficient, ultra-low-dosage agrochems. is desirable for protecting the health of crops and ensuring food security. Herein, a series of 1,3,4-oxadiazole derivatives bearing an isopropanol amine moiety was prepared, and the inhibitory activity against tobacco mosaic virus (TMV) was assessed. Notably, compound A14 (I) exhibited excellent anti-TMV protective activity with an EC50 value of 137.7 mg L-1, which was superior to that of ribavirin (590.0 mg L-1) and ningnanmycin (248.2 mg L-1). Moreover, the anti-TMV activity of some compounds could be further enhanced (by up to 5-30%) through supplementation with 0.1% auxiliaries. Biochem. assays suggested that compound A14 could suppress the biosynthesis of TMV and induce the plant’s defense response. Given these merits, designed compounds had outstanding bioactivities and unusual action mechanisms and were promising candidates for controlling plant viral diseases. The experimental process involved the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of some aromatic and aliphatic esters using WO3/ZrO2 solid acid catalyst under solvent free conditions》 was written by Guguloth, Vijaya Charan; Battu, Satyanarayana. Recommanded Product: 403-33-8This research focused ontungsten trioxide impregnate zirconium dioxide preparation surface area; alc carboxylic acid heterogeneous catalyst esterification green chem; carboxylic acid ester preparation. The article conveys some information:

A simple method was delineated for the synthesis of substituted ester products in superior yields by esterification reaction under solvent unbound condition using tungsten upgraded ZrO2 solid acid catalyst at 353 K. The WO3/ZrO2 catalyst was prepared by using impregnation method followed by calcination at 923 K over a period of 6 h in air atm. SEM, XRD, FTIR, and BET surface area techniques were used to categorize this catalyst. Zirconia has both acidic and basic possessions which was changed by incorporating suitable promoter atom like tungsten which in turn increases the surface area thereby enhancing the surface acidity. Impregnation of W6+ ions exhibited a strong influence on phase modification of zirconia from thermodynamically solid monoclinic to metastable tetragonal phase. Amalgamation of promoter W6+ will stabilize tetragonal phase which was active in catalyzing reactions. In esterification reaction WO3/ZrO2 catalyst was found to be stable, efficient and environmental friendly, effortlessly recovered by filtration, excellent yield of product and it was reusable efficiently. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: 403-33-8) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Acylation of oxindoles using methyl/phenyl esters via the mixed Claisen condensation-an access to 3-alkylideneoxindoles》 was published in Organic & Biomolecular Chemistry in 2020. These research results belong to Sreedharan, Ramdas; Rajeshwaran, Purushothaman; Panyam, Pradeep Kumar Reddy; Yadav, Saurabh; Nagaraja, C. M.; Gandhi, Thirumanavelan. Quality Control of Methyl 4-fluorobenzoate The article mentions the following:

Herein, simple acyl sources, viz. Me and Ph esters, which acylate oxindoles via the mixed Claisen condensation are reported. This straightforward protocol is mediated by LiHMDS and KOtBu and successfully applied to a wide range of substrates. It is a noteworthy transformation that skips the stepwise generation of enolates and acylation, and the reaction is performed at a moderate temperature with no side reactions. This protocol produces the first examples of ortho-substituents in an aryl ring flanked with electron-donating and electron-withdrawing substrates. Interestingly, robust organometallic ferrocenyl Me ester cleaved under these conditions with ease. Furthermore, biol. important Tenidap’s analog was synthesized by this protocol. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Quality Control of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Quality Control of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Rapid access to 3-acyl indoles using ethyl acetate/triflic acid couple as the acylium donor and Cu(OAc)2 catalysed aerial oxidation of indole benzoins》 was written by Talukdar, Ranadeep. Reference of Methyl 4-fluorobenzoate And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

A facile installation of acyl groups at the C-3 position of indoles under triflic acid catalyzed conditions with easily available and cheap esters as new acylating agents was described. Furthermore, heterocycles like N-protected pyrrole, furan and thiophene were also suitable substrates for similar C-2 acylation. Analogous C-3 benzoylated products of indole were obtained, albeit in lower yields, by using Me benzoate as a benzoyl donor. The benzoylated products were synthesized in much better yields via a copper(II) catalyzed aerial oxidation of indole containing benzoins. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Reference of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Reference of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics