Category: 403-33-8

An, Yi; Zhang, Fang; Du, Guangfen; Cai, Zhihua; He, Lin published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Construction of 6H-benzo[c]thiochromenes via a tandem reaction of arynes with thionoestersã€?Product Details of 403-33-8 The article contains the following contents:

A mild and transition-metal free tandem reaction for the construction of 6H-benzo[c]thiochromenes was developed. Thionoesters reacted with two mols. of arynes through a Diels-Alder cycloaddition/nucleophilic arylation process to afford 6-alkoxy-6-aryl-6H-benzo[c]thiochromenes I [R = Me, n-Bu, Bn, etc.; R1 = H, Me; R2 = H, Me, F, Cl, Br; R3 = H; R4 = H, Me, MeO; R5 = H, F; R6 = H, F; R7 = H, Me; R2R3 = CH=CH-CH=CH; Ar = Ph, 3-MeOC6H4, 2,5-di-MeC6H3, 3,4-di-FC6H3] in 37-80% yields. In addition, the Diels-Alder cycloaddition/aromatization tandem reaction of thionoesters with one mol. of aryne provided the construction of 6-alkoxyl-6H-benzo[c]thiochromenes II [R8 = Me, Et, n-Pr; R9 = H, F, Br; R10 = H, Me, Br, CH=CH2; R11 = H; R12 = H, F; R13 = H, F; R10R11 = CH=CH-CH=CH; R12R13 = CH=CH-CH=CH] in 51-75% yields. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Product Details of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 403-33-8In 2020 ,《Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions》 was published in Science China: Chemistry. The article was written by Chen, Hang; Chen, Dong-Huang; Huang, Pei-Qiang. The article contains the following contents:

Reported that by employing Ni(COD)2/2,2′-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcs. can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50°C/80°C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, N-acylindoles, and to other (functionalized) primary and secondary alcs. In all cases, only 1.5 equivalent of alc. were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asym. methodologies. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Avullala, Thirupataiah; Nguyen, Hiep H.; Dakarapu, Udaya Sree; Asgari, Parham; Hua, Yuanda; Jeon, Junha published an article in ACS Catalysis. The title of the article was 《Catalytic Net Oxidative C-C Activation and Silylation of Cyclopropanols with a Traceless Acetal Directing Group》.Related Products of 403-33-8 The author mentioned the following in the article:

Redox-neutral C-C (C-C) bond activation and functionalization strategies of cyclopropanols that give metallo homoenolate have offered merits to construct a range of useful β-functionalized ketones in an inverse-polarity fashion. Discovery and identification of oxidative C-C activation reactions of cyclopropanols that generate metallo enolate-homoenolate would provide an opportunity to afford α,β-difunctionalized ketones. The authors report catalytic, net oxidative C-C activation, and silylation of cyclopropanols with traceless acetal directing groups under consecutive Ir and Rh catalysis in regio-, stereo-, and chemo-selective fashion. In detail, Ir-catalyzed hydrosilylation of cyclopropyl acetates provides the acetal directing group in quant. yield. Rh-catalyzed proximal C-C silylation of the resulting cyclopropyl silyl acetal produces the metallo enolate-homoenolate equivalent, dioxasilepine, which uniquely holds an interconnected β-silyl moiety and Z-vinyl acetal. Upon sequential treatment of a silaphile that removes the acetal directing group and electrophile, the seven-membered Si-containing heterocycle, serving as the ketone α,β-dianion equivalent, delivers α,β-difunctionalized ketones. Scope of the hitherto unexplored reactivity of cyclopropanols toward net oxidative C-C silylation and the versatility of the resulting dioxasilepines were demonstrated. These include late-stage, net oxidative C-C silylation of biol. relevant mols. and facile production of a range of α,β-difunctionalized ketones. Preliminary mechanistic studies suggest that the C-C activation harnessing the electron-rich Wilkinson-type catalyst is likely the turnover-determining step and a Rh-π interaction is the key to the efficient metal insertion to the proximal C-C bond in cyclopropanols. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Related Products of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Related Products of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of New Zerumbone Hydrazones and Their In-vitro Anticancer Activity》 was written by Vu, Vu V.; Vu, Tran K.. Application of 403-33-8This research focused onzerumbone hydrazone invitro anticancer activity. The article conveys some information:

A series of new zerumbone hydrazones 5a-f and 9a-f have been synthesized in via an in situ procedure in high yields. The structure of synthesized compounds has been confirmed using 1H 13C NMR and HR-MS. The bioassay result showed that several compounds exhibited cytotoxic effects against three human cancer cell lines, including HepG-2, SK-LU-1, and MCF-7. Compound 9a showed the best cytotoxic effect against HepG-2, SK-LU-1, and MCF-7 with IC50 values of 8.20, 6.66, and 9.35 μM, resp. This study aims at developing new zerumbone hydrazones as anticancer agents based on zerumbone, a natural compound wildly growing in Vietnam. A series of new zerumbone hydrazones was designed, synthesized, and evaluated for cytotoxicity against three human cancer cell lines, including HepG-2, MCF-7, and SKLu-1, using the MTT method. Especially, compound 9a displayed the best cytotoxic effect against HepG-2, SK-LU-1, and MCF-7 with IC50 values of 8.20, 6.66, and 9.35 μM, resp. The research results suggest that some compounds could be considered as leads for the future design of zerumbone hydrazones in which bio-isosteric replacements in theortho position of the Ph ring could be performed to improve the cytotoxic activity. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of Methyl 4-fluorobenzoateIn 2021 ,《Practical and rapid construction of 2-pyridyl ketone library in continuous flow》 appeared in Journal of Flow Chemistry. The author of the article were Sun, Maolin; Li, Jianchang; Liang, Chaoming; Shan, Chao; Shen, Xinyuan; Cheng, Ruihua; Ma, Yueyue; Ye, Jinxing. The article conveys some information:

Herein, a practical method for the rapid synthesis of 2-pyridyl ketone ArC(O)R [Ar = 2-pyridyl; R = Me, Ph, Bn, etc.] library in continuous flow was reported, in which the 2-lithiopyridine formed by Br/Li exchange reacts with com. available esters to obtain 2-pyridyl ketones ArC(O)R in a good yield at short reaction time. This protocol functions broadly on a variety of esters and had been applied to the synthesis of TGF-β type 1 receptor inhibitor LY580276 intermediate ArC(O)R [Ar = 6-methyl-2-pyridyl; R = (4-fluorophenyl)methyl] in an environmentally friendly method. It was rapid, reliable, and cost-efficient to afford diverse kinds of 2-pyridyl ketones ArC(O)R in the compound library. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Application In Synthesis of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application In Synthesis of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Ni, Congjian; Yu, Hailong; Liu, Ling; Yan, Ben; Zhang, Bingyi; Ma, Xiaoli; Zhang, Xiuhui; Yang, Zhi published an article in New Journal of Chemistry. The title of the article was 《An efficient catalytic method for the borohydride reaction of esters using diethylzinc as precatalyst》.Synthetic Route of C8H7FO2 The author mentioned the following in the article:

A cheap and easily available ZnEt2 is an effective precatalyst, which can be used for the hydroboration reaction of various organic carbonates and esters with HBpin. The preliminary hydroboration reaction mechanism has been investigated via the corresponding DFT calculation In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Synthetic Route of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Synthetic Route of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Methoxylation of Acyl Fluorides with Tris(2,4,6-trimethoxyphenyl)phosphine via C-OMe Bond Cleavage under Metal-Free Conditions》 was written by Wang, Xiu; Wang, Zhenhua; Ishida, Takumi; Nishihara, Yasushi. Electric Literature of C8H7FO2 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

Aryl fluorides (prepared from the corresponding aryl chlorides) underwent methoxylation reactions with tris(2,4,6-trimethoxyphenyl)phosphine (TMPP) (in the absence of added metal catalysts or reagents) in toluene to yield Me esters. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Electric Literature of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Electric Literature of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Fangcao; Gong, Mingliang; Xie, Hongzhen; Luo, Yunjie published their research in New Journal of Chemistry in 2021. The article was titled 《La(CH2C6H4NMe2-o)3-catalyzed reduction of esters to alcohols with pinacolborane》.Product Details of 403-33-8 The article contains the following contents:

La(CH2C6H4NMe2-o)3, a simple and facilely accessible lanthanide complex, can serve as a highly efficient catalyst for the reduction of esters e.g., Me 4-(trifluoromethyl)benzoate with pinacolborane (HBpin), selectively affording alcs. e.g., [4-(trifluoromethyl)phenyl]methanol in good yields under mild conditions. This protocol exhibits good tolerance for many functional groups such as C=C double bond, nitro, halogen, furyl, and thienyl groups. A lanthanum hydride species like [La]-H.HBpin is proposed to play a crucial role in promoting the interaction of esters with HBpin. In the experiment, the researchers used Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Product Details of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiao, Jing; Guo, Fengzhe; Li, Yinfeng; Li, Fangshao; Li, Qiang; Tang, Zi-Long published an article in 2021. The article was titled 《Iodine Promoted Conversion of Esters to Nitriles and Ketones under Metal-Free Conditions》, and you may find the article in Journal of Organic Chemistry.Formula: C8H7FO2 The information in the text is summarized as follows:

In the present study, novel strategy to prepare valuable nitriles and ketones through the conversion of esters under metal-free conditions were reported. By using the I2/PCl3 system, various substrates including aliphatic and aromatic esters reacted with acetonitrile and arenes to afford the desired products in good to excellent yields. This method was compatible with a number of functional groups and provided a simple and practical approach for the synthesis of nitrile compounds and aryl ketones. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Formula: C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Formula: C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Xin; Zhao, Lijie; Xiang, Weiguo; Qin, Chong; Miao, Bukeyan; McEachern, Donna; Wang, Yu; Metwally, Hoda; Wang, Lu; Matvekas, Aleksas; Wen, Bo; Sun, Duxin; Wang, Shaomeng published an article in 2021. The article was titled 《Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer》, and you may find the article in Journal of Medicinal Chemistry.Recommanded Product: Methyl 4-fluorobenzoate The information in the text is summarized as follows:

Proteolysis targeting chimera (PROTAC) small-mol. degraders have emerged as a promising new type of therapeutic agents, but the design of PROTAC degraders with excellent oral pharmacokinetics is a major challenge. In this study, we present our strategies toward the discovery of highly potent PROTAC degraders of androgen receptor (AR) with excellent oral pharmacokinetics. Employing thalidomide to recruit cereblon/cullin 4A E3 ligase and through the rigidification of the linker, we discovered highly potent AR degraders with good oral pharmacokinetic properties in mice with ARD-2128 (I) being the best compound ARD-2128 achieves 67% oral bioavailability in mice, effectively reduces AR protein and suppresses AR-regulated genes in tumor tissues with oral administration, leading to the effective inhibition of tumor growth in mice without signs of toxicity. This study supports the development of an orally active PROTAC AR degrader for the treatment of prostate cancer and provides insights and guidance into the design of orally active PROTAC degraders. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics