Category: 403-33-8

Application of 403-33-8In 2020 ,《Structure based discovery of novel hexokinase 2 inhibitors》 was published in Bioorganic Chemistry. The article was written by Liu, Yang; Li, Mingxue; Zhang, Yujie; Wu, Canrong; Yang, Kaiyin; Gao, Suyu; Zheng, Mengzhu; Li, Xingzhou; Li, Hua; Chen, Lixia. The article contains the following contents:

Hexokinase 2 (HK2) is over-expressed in most of human cancers and has been proved to be a promising target for cancer therapy. In this study, based on the structure of HK2, we screened over 6 millions of compounds to obtain the lead. A total of 26 (E)-N’-(2,3,4-trihydroxybenzylidene) arylhydrazide derivatives were then designed, synthesized, and evaluated for their HK2 enzyme activity and IC50 values against two cancer cell lines. Most of the 26 target compounds showed excellently in vitro activity. Among them, compound 3j showed the strongest inhibitory effects on HK2 enzyme activity with an IC50 of 0.53 ± 0.13μM and exhibited the most potent growth inhibition against SW480 cells with an IC50 of 7.13 ± 1.12μM, which deserves further studies. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Application of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Kong, Xianqiang; Chen, Yiyi; Chen, Xiaohui; Lu, Zheng-Xuan; Wang, Wei; Ni, Shao-Fei; Cao, Zhong-Yan published an article in Organic Letters. The title of the article was 《A Practically Unified Electrochemical Strategy for Ni-Catalyzed Decarboxylative Cross-Coupling of Aryl Trimethylammonium Salts》.Safety of Methyl 4-fluorobenzoate The author mentioned the following in the article:

By merging electrocatalysis and nickel catalysis, a unified strategy was successfully applied for preparing aryl ketones ArC(O)Ph [Ar = Ph, 4-ClC6H4, 4-MeC6H4, etc.], amides ArC(O)NR1R2 [Ar = Ph, 4-ClC6H4, 4-MeC6H4, etc.; R1 = R2 = Me, Et; R1R2 = CH2(CH2)2CH2, CH2CH2OCH2CH2], esters ArC(O)OR [Ar = Ph, 2-MeC6H4, 4-FC6H4, etc.; R = Me, Et] or aldehydes ArCHO [Ar = Ph, 4-MeC6H4, 4-PhC6H4, etc.] via decarboxylative cross-coupling of four types of α-oxocarboxylic acids and their derivatives with aryl trimethylammonium salts under mild conditions.Methyl 4-fluorobenzoate(cas: 403-33-8Safety of Methyl 4-fluorobenzoate) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Safety of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of azido-substituted benzaldehydes via SNAr chemistry》 was published in Tetrahedron Letters in 2020. These research results belong to Kafle, Arjun; Yossef, Sandy; Handy, Scott T.. Formula: C8H7FO2 The article mentions the following:

Conditions for the formation of azidobenzaldehydes and azidobenzonitriles using sodium azide in DMSO under typical SNAr conditions are described. This simplifies access to these valuable building blocks compared to the more common sequences reported in the literature. Interestingly, fluorosubstituted aryl ketones and esters do not afford azides, but instead amine products.Methyl 4-fluorobenzoate(cas: 403-33-8Formula: C8H7FO2) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Formula: C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Yi-Jie; Zhang, Guo-Yu; Shoberu, Adedamola; Zou, Jian-Ping published their research in Tetrahedron Letters in 2021. The article was titled 《Iron-catalyzed oxidative amidation of acylhydrazines with amines》.Name: Methyl 4-fluorobenzoate The article contains the following contents:

A new approach for amide bond formation via a mild and efficient iron-catalyzed cross-coupling reaction of acylhydrazines and amines using TBHP as oxidant was described. This protocol was compatible with a wide range of amines and acylhydrazines. In addition, the synthetic application of the reaction was presented.Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Name: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Ag/Pd Cocatalyzed Direct Arylation of Fluoroarene Derivatives with Aryl Bromides》 was published in ACS Catalysis in 2020. These research results belong to Panigrahi, Adyasha; Whitaker, Daniel; Vitorica-Yrezabal, Inigo J.; Larrosa, Igor. SDS of cas: 403-33-8 The article mentions the following:

Diverse C-H functionalizations catalyzed by Pd employ Ag(I) salts added as halide abstractors or oxidants. Recent reports have shown that Ag can also perform the crucial C-H activation step in several of these functionalizations. However, all of these processes are limited by the wasteful requirement for (super)stoichiometric Ag(I) salts. Herein, we report the development of a Ag/Pd cocatalyzed direct arylation of (fluoroarene) chromium tricarbonyl complexes with bromoarenes. The small organic salt, NMe4OC(CF3)3, added as a halide abstractor, enables the use of a catalytic amount of Ag, reversing the rapid precipitation of AgBr. We have shown through H/D scrambling and kinetic studies that a (PR3)Ag-alkoxide is responsible for C-H activation, a departure from previous studies with Ag carboxylates. Furthermore, the construction of biaryls directly from the simple arene is achieved via a one-pot chromium tricarbonyl complexation/C-H arylation/decomplexation sequence using (pyrene)Cr(CO)3 as a Cr(CO)3 donor. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.SDS of cas: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of Benzo[b]furans by Intramolecular C-O Bond Formation Using Iron and Copper Catalysis》 was published in Organic Letters in 2020. These research results belong to Henry, Martyn C.; Sutherland, Andrew. SDS of cas: 403-33-8 The article mentions the following:

One-pot processes for the synthesis of benzo[b]furans from 1-aryl- or 1-alkylketones using nonprecious transition metal catalysts have been developed. Regioselective iron(III)-catalyzed halogenation of the aryl ring, followed by iron- or copper-catalyzed O-arylation allowed the synthesis of various structural analogs, including the benzo[b]furan-derived natural products corsifuran C, moracin F, and caleprunin B. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.SDS of cas: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Design, Synthesis, and Pharmacological Evaluation of First-in-Class Multitarget N-Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors》 was published in ChemMedChem in 2020. These research results belong to Rodrigues, Daniel A.; Guerra, Fabiana S.; Sagrillo, Fernanda S.; Pinheiro, Pedro de Sena M.; Alves, Marina A.; Thota, Sreekanth; Chaves, Lorrane S.; Sant’Anna, Carlos M. R.; Fernandes, Patricia D.; Fraga, Carlos A. M.. HPLC of Formula: 403-33-8 The article mentions the following:

Targeting histone deacetylases (HDACs) and phosphatidylinositol 3-kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes the design, synthesis, in vitro pharmacol. profile, and mol. modeling of a novel class of N-acylhydrazone (NAH) derivatives that act as HDAC6/8 and PI3Kα dual inhibitors. The surprising selectivity for PI3Kα may be related to differences in the conformation in the active site. Cellular studies showed that these compounds act in HDAC6 inhibition and the PI3/K/AKT/mTOR pathway. The compounds that are selective for inhibition of HDAC6/8 and inhibit PI3Kα show potential for the treatment of cancer. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8HPLC of Formula: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.HPLC of Formula: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Yu, Xiangzhu; Zhao, Zhengjia; Zhu, Lina; Tan, Shangzhi; Fu, Weiru; Wang, Lianyue; An, Yue published an article in Molecular Catalysis. The title of the article was 《Aerobic oxidative cleavage and esterification of C=C bonds catalyzed by iron-based nanocatalyst》.SDS of cas: 403-33-8 The author mentioned the following in the article:

An efficient protocol for the direct formation of esters by oxidative cleavage of C=C bonds using heterogeneous iron nanocomposite catalyst supported on nitrogen-doped carbon materials with mol. oxygen and tert-butylhydroperoxide (TBHP) as the oxidants was reported. The results showed that mol. oxygen as the terminal oxidant was mainly responsible for the cleavage process, and that the auxiliary oxidant TBHP promotes the formation of the intermediate epoxide, thus increasing the selectivity of the product. The catalytic system has a wide range of substrate compatibility involving the challenging inactive aliphatic and long-chain alkyl aryl olefins. The catalyst was reused seven times with no loss in catalytic activity. Characterization and control experiments uncovered that the core-shell Fe and Fe3C nanoparticles encapsulated by graphitic carbon play a predominant role in catalyzing the oxidative cleavage of olefins to esters. Preliminary mechanistic studies disclosed that this process involved both free radical reactions and tandem sequential reactions. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.SDS of cas: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Design and development of 1,3,5-triazine-thiadiazole hybrids as potent adenosine A2A receptor (A2AR) antagonist for benefit in Parkinson’s disease》 was written by Masih, Anup; Singh, Saumya; Agnihotri, Amol Kumar; Giri, Sabeena; Shrivastava, Jitendra Kumar; Pandey, Nidhi; Bhat, Hans Raj; Singh, Udaya Pratap. Recommanded Product: Methyl 4-fluorobenzoateThis research focused ontriazine thiadiazole hybrid antiParkinson neuroprotectant A2AR antagonist Parkinsons disease; 1,3,5-triazine; Adenosine A(2)A receptor; Antagonist; Docking; Parkinson’s disease. The article conveys some information:

Various studies showed adenosine A2A receptors (A2ARs) antagonists have profound therapeutic efficacy in Parkinsons Disease (PD) by improving dopamine transmission, thus being active in reversing motor deficits and extrapyramidal symptoms related to the disease. Therefore, in the presents study, we have showed the development of novel 1,3,5-triazine-thiadiazole derivative as potent A2ARs antagonist. In the radioligand binding assay, these mols. showed excellent binding affinity with A2AR compared to A1R, with significant selectivity. Results suggest, compound 7e as most potent antagonist of A2AR among the tested series. In docking anal. with A2AR protein model, compound 7e found to be deeply buried into the cavity of receptor lined via making numerous interat. contacts with His264, Tyr271, His278, Glu169, Ala63, Val84, Ile274, Met270, Phe169. Collectively, our study demonstrated 1,3,5-triazine-thiadiazole hybrid as a highly effective scaffold for the design of new A2A antagonists.Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Biswas, Rayhan G.; Ray, Sumit K.; Unhale, Rajshekhar A.; Singh, Vinod K. published an article in 2021. The article was titled 《Organocatalytic Asymmetric Cascade Michael-acyl Transfer Reaction between 2-Fluoro-1,3-diketones and Unsaturated Thiazolones: Access to Fluorinated 4-Acyloxy Thiazoles》, and you may find the article in Organic Letters.Name: Methyl 4-fluorobenzoate The information in the text is summarized as follows:

Quinine derived bifunctional urea catalyzed cascade Michael-acyl transfer reaction of 5-alkenyl thiazolones I (R = H, 2-Br, 3-Cl, 4-CF3, etc.; Ar = 4-fluorophenyl, naphthalen-2-yl, thien-2-yl, etc.) and monofluorinated β-diketones R1C(O)CH(F)C(O)R2 (R1 = Me, Ph, 4-chlorophenyl, etc.; R2 = Ph, 2-methylphenyl, 4-chlorophenyl, etc.) has been developed. The fluorine containing 4-acyloxy thiazoles (1R,2S)-II were synthesized in high yields and good diastereo- and excellent enantioselectivities. Synthetic transformations, including synthesis of 4-hydroxy thiazoles (1R,2S)-II, have been demonstrated. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics