Category: 403-33-8

Li, Guoshuai; Yan, Yifei; Zhang, Pengfei; Xu, Xiaohua; Jin, Zhong published their research in ACS Catalysis in 2021. The article was titled 《Palladium-Catalyzed meta-Selective C-H Functionalization by Noncovalent H-Bonding Interaction》.Quality Control of Methyl 4-fluorobenzoate The article contains the following contents:

Herein, a palladium-catalyzed meta-selective C-H olefination of aromatic carbonyl compounds such as acetophenone, benzaldehyde, Me benzoate, N,N-diisopropylbenzamide, etc. by noncovalent hydrogen-bonding interaction was reported. N,N’-Substituted ureas RNHC(O)NHR1 [R = cyclohexyl, 3,5-bis(trifluoromethyl)phenyl; R1 = cyclohexyl, 2-(2-cyanophenoxy)ethyl, 2-phenoxyethyl, etc.] were engineered to serve as a H-bonding donor for binding to the substrates and, meanwhile, achieve site-selective control by the integrated directing group. In addition to this study using Methyl 4-fluorobenzoate, there are many other studies that have used Methyl 4-fluorobenzoate(cas: 403-33-8Quality Control of Methyl 4-fluorobenzoate) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Quality Control of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Lekkala, Chinnari; Bodala, Varaprasad; Yettula, Kumari; Karasala, Bharat Kumar; Podugu, Rajitha Lakshmi; Vidavalur, Siddaiah published an article in ACS Omega. The title of the article was 《Copper-Catalyzed One-Pot Synthesis of 2,5-Disubstituted 1,3,4-Oxadiazoles from Arylacetic Acids and Hydrazides via Dual Oxidation》.Electric Literature of C8H7FO2 The author mentioned the following in the article:

A simple and efficient protocol was developed to access sym. and unsym. 2,5-disubstituted 1,3,4-oxadiazoles from arylacetic acids and hydrazides via copper-catalyzed dual oxidation under an oxygen atm. Oxidative decarboxylation of arylacetic acids and oxidative functionalization of the imine C-H bond were the key steps. This was the first example of the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles through dual oxidation in one-pot. Avoidance of the expensive ligand and high yield of the products were advantageous features of the developed method. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Electric Literature of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Electric Literature of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Ruthenium-catalyzed hydrogenation of CO2 as a route to methyl esters for use as biofuels or fine chemicals》 was published in Chemical Science in 2020. These research results belong to Wang, Zheng; Zhao, Ziwei; Li, Yong; Zhong, Yanxia; Zhang, Qiuyue; Liu, Qingbin; Solan, Gregory A.; Ma, Yanping; Sun, Wen-Hua. Application In Synthesis of Methyl 4-fluorobenzoate The article mentions the following:

A novel robust diphosphine-ruthenium(II) complex has been developed that can efficiently catalyze both the hydrogenation of CO2 to methanol and its in situ condensation with carboxylic acids to form Me esters; a TON of up to 3260 is achievable for the CO2 to methanol step. Both aromatic and aliphatic carboxylic acids can be transformed to their corresponding Me esters with high conversion and selectivity (17 aliphatic and 18 aromatic examples). On the basis of a series of experiments, a mechanism has been proposed to account for the various steps involved in the catalytic pathway. More importantly, this approach provides a promising route for using CO2 as a C1 source for the production of biofuels, fine chems. and methanol. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Application In Synthesis of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Application In Synthesis of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《C(sp2)-H Activation with Pyridine Dicarbene Iron Dialkyl Complexes: Hydrogen Isotope Exchange of Arenes Using Benzene-d6 as a Deuterium Source》 was written by Corpas, Javier; Viereck, Peter; Chirik, Paul J.. Computed Properties of C8H7FO2 And the article was included in ACS Catalysis in 2020. The article conveys some information:

Treatment of pyridine dicarbene iron dialkyl complexes with low (≪1 atm) pressures of H2 in a benzene-d6 solution promoted rapid hydrogen isotope exchange (HIE) of the C(sp2)-H bonds in both electron-poor and -rich aromatic and heteroaromatic rings with benzene-d6 as the deuterium source. The iron-catalyzed reaction proceeded with predictable regioselectivity, engaging sterically accessible C-H bonds including ortho-to-fluorine sites. The site selectivity for the catalytic HIE reaction was studied to identify the kinetic preferences for C-H activation. Structure-activity relationship studies with a series of iron precatalysts established that introduction of substituents at the 3- and 5-positions of pyridine of the pincer significantly accelerated HIE. Mechanistic studies identified N2 as an inhibitor of C-H activation, while H2 served to generate the active catalyst. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Computed Properties of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Computed Properties of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Yan, Ben; Dutta, Sayan; Ma, Xiaoli; Ni, Congjian; Koley, Debasis; Yang, Zhi; Roesky, Herbert W. published an article in Dalton Transactions. The title of the article was 《Organoaluminum hydrides catalyzed hydroboration of carbonates, esters, carboxylic acids, and carbon dioxide》.Recommanded Product: 403-33-8 The author mentioned the following in the article:

Reduction of carbonates, carboxylic acids and ester was achieved in reaction with HBpin and [(nacnac)AlH2] catalyst. The reductive functionalization of the C:O unit of carbonates, carboxylic acids, esters, and CO2, resp. has received great attention since its introduction. This method is often used industrially for the synthesis of high value-added energy products in chem. This opens up a new way forward to reduce greenhouse gases and the consumption of traditional energy sources. Herein, we report an earth-abundant, cheap, and readily available aluminum dihydride, which can catalyze the reduction of a range of carbonates, esters, carboxylic acids, and CO2, resp. in the presence of pinacolborane as a reducing agent. Moreover, we demonstrate that the reaction can proceed to obtain good yield products under mild conditions, with low catalyst loading and solvent-free reactions. The mechanism of the catalytic reduction of carbonates has been investigated. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Recommanded Product: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

COA of Formula: C8H7FO2In 2021 ,《Efficient synthesis of primary and secondary amides via reacting esters with alkali metal amidoboranes》 appeared in Nature Communications. The author of the article were Guo, Yu; Wang, Ruo-Ya; Kang, Jia-Xin; Ma, Yan-Na; Xu, Cong-Qiao; Li, Jun; Chen, Xuenian. The article conveys some information:

Authors report here a facile synthesis method of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH3, R = H, Me), at room temperature without using catalysts and other reagents. This process is rapid and chemoselective, and features quant. conversion and wide applicability for esters tolerating different functional groups. The exptl. and theor. studies reveal a reaction mechanism with nucleophilic addition followed by a swift proton transfer-induced elimination reaction. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8COA of Formula: C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.COA of Formula: C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Continuous-Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex》 was published in ChemSusChem in 2020. These research results belong to Oetvoes, Sandor B.; Kappe, C. Oliver. Recommanded Product: Methyl 4-fluorobenzoate The article mentions the following:

A simple process was developed in which neat borane dimethylsulfide complex (BH3·DMS) was used to reduce various esters RC(O)OR1 (R = C6H5, cyclohexyl, 2-naphthyl, etc.; R1 = CH3, C2H5, C6H5, CH2C6H5) and amides R2C(O)NR3R4 (R2 = H, Me, Ph; R3 = C6H5, 1-naphthyl, CH2C6H5, etc.; R4 = H, Me, Ph) under continuous-flow conditions. Taking advantage of the solvent-free nature of the com. available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E-factors. In addition, with carefully optimized short residence times, the corresponding alcs. RCH2OH and amines R2CH2NR3R4 were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram-scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.Methyl 4-fluorobenzoate(cas: 403-33-8Recommanded Product: Methyl 4-fluorobenzoate) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Recommanded Product: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Jingjing; Jiang, Feng; Tao, Chaofu; Yu, Han; Ruhlmann, Laurent; Wei, Yongge published their research in Green Chemistry in 2021. The article was titled 《Oxidative esterification of alcohols by a single-side organically decorated Anderson-type chrome-based catalyst》.Synthetic Route of C8H7FO2 The article contains the following contents:

The direct esterification of alcs. with non-noble metal-based catalytic systems faces great challenges. Here, we report a new chrome-based catalyst stabilized by a single pentaerythritol decorated Anderson-type polyoxometalate, [N(C4H9)4]3[CrMo6O18(OH)3C{(OCH2)3CH2OH}], which can realize the efficient transformation from alcs. to esters by H2O2 oxidation in good yields and high selectivity without extra organic ligands. A variety of alcs. with different functionalities including some natural products and pharmaceutical intermediates are tolerated in this system. The chrome-based catalyst can be recycled several times and still keep the original configuration and catalytic activity. We also propose a reasonable catalytic mechanism and prove the potential for industrial applications. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Synthetic Route of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Synthetic Route of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ning, Yongquan; Song, Qingmin; Sivaguru, Paramasivam; Wu, Lizuo; Anderson, Edward A.; Bi, Xihe published an article in 2022. The article was titled 《Ag-Catalyzed Insertion of Alkynyl Carbenes into C-C Bonds of β-Ketocarbonyls: A Formal C(sp2) Insertion》, and you may find the article in Organic Letters.SDS of cas: 403-33-8 The information in the text is summarized as follows:

Herein, a silver-catalyzed alkynyl carbene insertion into β-ketocarbonyls I (R1 = R3 = Me, Et, Ph, 4-t-BuC6H4, 3-thienyl, etc., R2 = H; R1 = Ph, R2 = H, R3 = Me, 4-F3CC6H4; R1 = R3 = Me, R2 = Me, Et, PhCH2; etc.) using alkynyl N-nosylhydrazones II [R4 = cyclopropyl, Cl(CH2)3, Ph, 3-MeOC6H4, 3,5-Cl2C6H3, 2-naphthyl, 1-cyclohexen-1-yl, etc.; Ns = 2-nitrophenylsulfonyl] as alkynyl carbene precursors, which provides access to trisubstituted allenyl ketones III, is reported. This reaction represents the first example of an alkynyl carbene insertion into a C-C σ bond, affording products homologated with an sp2 carbon center. The products are useful substrates for further transformations. Exptl. investigations and theor. calculations suggest the reaction proceeds through a stepwise enol cyclopropanation/retro-aldol pathway. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8SDS of cas: 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.SDS of cas: 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Pflegr, Vaclav; Stepankova, Sarka; Svrckova, Katarina; Svarcova, Marketa; Vinsova, Jarmila; Kratky, Martin published an article in Pharmaceuticals. The title of the article was 《5-Aryl-1,3,4-oxadiazol-2-amines Decorated with Long Alkyl and Their Analogues: Synthesis, Acetyl- and Butyrylcholinesterase Inhibition and Docking Study》.Safety of Methyl 4-fluorobenzoate The author mentioned the following in the article:

The compounds 5-aryl-1,3,4-oxadiazoles/thiadiazols decorated with dodecyl linked via nitrogen, sulfur or directly to this heterocycle I [R = Ph, 4-MeC6H4, 4-tBuC6H4, etc.,; X = O, S; Y = NH, S] was designed as potential inhibitors of AChE and BChE. Oxadiazoles/thiadiazols derivatives I were prepared from hydrazides by reaction with dodecyl isocyanate to form hydrazine-1-carboxamides II (yields 67-98%) followed by cyclization using p-toluenesulfonyl chloride and triethylamine in 41-100% yields. The derivatives I were screened for inhibition of AChE and BChE using Ellman’s spectrophotometric method. The compounds I showed a moderate dual inhibition with IC50 values of 12.8-99.2 for AChE and from 53.1μM for BChE. All the heterocycles I were more efficient inhibitors of AChE. The most potent inhibitor, N-dodecyl-5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine I [R =4-pyridyl, X= S, Y = NH] was subjected to advanced reversibility and type of inhibition evaluation. Structure-activity relationships of heterocycles I were identified. Many oxadiazoles I showed lower IC50 values against AChE than established drug rivastigmine. According to mol. docking, the compounds I interact non-covalently with AChE and BChE and block entry into enzyme gorge and catalytic site, resp. The experimental process involved the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Safety of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Safety of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics