Category: 403-33-8

Xu, Jin-Di; Su, Xiao-Bo; Wang, Cai; Yao, Li-Wei; Liu, Jing-Hui; Hu, Guo-Qin published their research in Synlett in 2021. The article was titled 《Mild Copper-Catalyzed Addition of Arylboronic Esters to Di- tert -butyl Dicarbonate: An Easy Access to Methyl Arylcarboxylatesã€?Application of 403-33-8 The article contains the following contents:

An efficient copper-catalyzed addition of arylboronic esters to (Boc)2O was developed. The reaction can be conducted under exceedingly mild conditions and was compatible with a variety of synthetically relevant functional groups. It therefore represents a useful alternative route for the synthesis of Me arylcarboxylates. A preliminary mechanistic study indicated the involvement of an addition-elimination mechanism. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluorobenzoate(cas: 403-33-8Application of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Application of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Luo, Shihui; Weng, Chaoqun; Ding, Yuxuan; Ling, Chen; Szostak, Michal; Ma, Xiaodong; An, Jie published their research in Synlett in 2021. The article was titled 《Reductive Deuteration of Aromatic Esters for the Synthesis of α,α-Dideuterio Benzyl Alcohols Using D2O as Deuterium Sourceã€?Quality Control of Methyl 4-fluorobenzoate The article contains the following contents:

The first general single-electron transfer reductive deuteration of readily com. available aromatic esters for the synthesis of α,α-dideuterio benzyl alcs. RCH(D2)OH [R = Ph, 4-MeC6H4, 2-FC6H4, etc.] using benign D2O and a mild single-electron donor SmI2 was developed. This operationally convenient method featured very good functional group tolerance and high deuterium incorporations (>95% D2). The potential impact was exemplified by the synthesis of numerous deuterium labeled building blocks of important bioactive compounds Most crucially, the method represented the first example of selective reductive deuteration of benzylic-type ketyl radicals using mild and highly chemoselective lanthanide(II) reagents. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluorobenzoate(cas: 403-33-8Quality Control of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Quality Control of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Lian; Zhang, Cheng-Pan published their research in ACS Omega in 2021. The article was titled 《Revisiting the Balz-Schiemann Reaction of Aryldiazonium Tetrafluoroborate in Different Solvents under Catalyst- and Additive-Free Conditionsã€?Reference of Methyl 4-fluorobenzoate The article contains the following contents:

The thermal and photochem. Balz-Schiemann reaction in commonly used solvents was revisited under catalyst- and additive-free conditions. The study showed that using low- or non-polar solvents could improve the pyrolysis and photolysis of aryldiazonium tetrafluoroborates, enabling effective fluorination at a low temperature or under visible-light irradiation PhCl and hexane were exemplified as cheap and reliable solvents for both reactions, providing good to excellent yields of aryl fluorides ArF [Ar = Ph, 4-FC6H4, 3,4,5-tri-MeOC6H2, etc.] from the corresponding diazonium tetrafluoroborates. The combination of slight heating with visible-light irradiation was beneficial for the transformation of stable aryldiazonium tetrafluoroborates. Nevertheless, the electronic and steric nature of aryldiazonium tetrafluoroborates still had a pivotal effect on both fluorinations even in these solvents. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Reference of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Reference of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Discovery of [1,2,4]triazole derivatives as new metallo-β-lactamase inhibitorsã€?was written by Yuan, Chen; Yan, Jie; Song, Chen; Yang, Fan; Li, Chao; Wang, Cheng; Su, Huiling; Chen, Wei; Wang, Lijiao; Wang, Zhouyu; Qian, Shan; Yang, Lingling. Name: Methyl 4-fluorobenzoateThis research focused ontriazole derivative metallo beta lactamase inhibitor; VIM-2; metallo-β-lactamase; serine β-lactamase; triazole; β-lactam resistance. The article conveys some information:

The emergence and spread of metallo-β-lactamase (MBL)-mediated resistance to β-lactam antibacterials has already threatened the global public health. A clin. useful MBL inhibitor that can reverse β-lactam resistance has not been established yet. We here report a series of [1,2,4]triazole derivatives and analogs, which displayed inhibition to the clin. relevant subclass B1 (Verona integron-encoded MBL-2) VIM-2. 3-(4-Bromophenyl)-6,7-dihydro-5H-[1,2,4]triazolo [3,4-b][1,3]thiazine (5l) manifested the most potent inhibition with an IC50 (half-maximal inhibitory concentration) value of 38.36μM. Investigations of 5l against other B1 MBLs and the serine β-lactamases (SBLs) revealed the selectivity to VIM-2. Mol. docking analyses suggested that 5l bound to the VIM-2 active site via the triazole involving zinc coordination and made hydrophobic interactions with the residues Phe61 and Tyr67 on the flexible L1 loop. This work provided new triazole-based MBL inhibitors and may aid efforts to develop new types of inhibitors combating MBL-mediated resistance. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Name: Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Name: Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Glaser, Felix; Wenger, Oliver S. published an article in JACS Au. The title of the article was 《Red Light-Based Dual Photoredox Strategy Resembling the Z-Scheme of Natural Photosynthesisã€?Reference of Methyl 4-fluorobenzoate The author mentioned the following in the article:

Photoredox catalysis typically relies on the use of single chromophores, whereas strategies, in which two different light absorbers are combined, are rare. In photosystems I and II of green plants, the two sep. chromophores P680 and P700 both absorb light independently of one another, and then their excitation energy is combined in the so-called Z-scheme, to drive an overall reaction that is thermodynamically very demanding. Here, we adapt this concept to perform photoredox reactions on organic substrates with the combined energy input of two red photons instead of blue or UV light. Specifically, a CuI bis(α-diimine) complex in combination with in situ formed 9,10-dicyanoanthracenyl radical anion in the presence of excess diisopropylethylamine catalyzes ca. 50 dehalogenation and detosylation reactions. This dual photoredox approach seems useful because red light is less damaging and has a greater penetration depth than blue or UV radiation. UV-vis transient absorption spectroscopy reveals that the subtle change in solvent from acetonitrile to acetone induces a changeover in the reaction mechanism, involving either a dominant photoinduced electron transfer or a dominant triplet-triplet energy transfer pathway. Our study illustrates the mechanistic complexity in systems operating under multiphotonic excitation conditions, and it provides insights into how the competition between desirable and unwanted reaction steps can become more controllable. In the experimental materials used by the author, we found Methyl 4-fluorobenzoate(cas: 403-33-8Reference of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Reference of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Nickel-Catalyzed Carbonylation of Secondary Trifluoromethylated, Difluoromethylated and Nonfluorinated Aliphatic Electrophiles with Arylboronic Acids under 1 atm of CO》 was written by Cheng, Ran; Zhao, Hai-Yang; Zhang, Shu; Zhang, Xingang. Product Details of 403-33-8This research focused ontrifluoromethyl alkyl ketone preparation; alkyl halide arylboronic acid carbonylation carbon monoxide nickel catalyst. The article conveys some information:

The nickel-catalyzed carbonylation of aliphatic electrophiles with the most straightforward CO remains challenging. An example of the nickel-catalyzed carbonylation of secondary alkyl halides with arylboronic acids under 1 atm of CO is reported. The reaction exhibits high functional group tolerance and broad substrate scope, including trifluoromethylated, difluoromethylated and difluoroacetylated secondary alkyl iodides and secondary benzyl bromides, providing a general and cost-efficient method to access alkyl ketones, especially -trifluoromethylated alkyl ketones that are of great interest in medicinal chem. Preliminary mechanistic studies reveal that a bimetallic oxidative addition is likely involved in the reaction. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Product Details of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Product Details of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Highly Chemo- and Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids》 was written by Liu, Xian; Wen, Jialin; Yao, Lin; Nie, Huifang; Jiang, Ru; Chen, Weiping; Zhang, Xumu. Computed Properties of C8H7FO2 And the article was included in Organic Letters in 2020. The article conveys some information:

The highly chemo- and enantioselective hydrogenation of (E)-2-substituted-4-oxo-2-alkenoic acids was established for the first time using the Rh/JosiPhos complex, affording a series of chiral α-substituted-γ-keto acids with excellent results (up to 99% yield and >99% ee) and high efficiency (up to 3000 TON). In addition, the importance of this methodol. was further demonstrated by a concise and gram-scale synthesis of the anti-inflammatory drug (R)-flobufen. In the experiment, the researchers used many compounds, for example, Methyl 4-fluorobenzoate(cas: 403-33-8Computed Properties of C8H7FO2)

Methyl 4-fluorobenzoate(cas: 403-33-8) can be used in the synthesis of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety.Computed Properties of C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Hui; Jia, Rui; Hong, Mei; Miao, Hongyan; Ni, Bangqing; Niu, Tengfei published their research in Green Chemistry in 2021. The article was titled 《Hydroxyl radical-mediated oxidative cleavage of C=C bonds and further esterification reaction by heterogeneous semiconductor photocatalysis》.COA of Formula: C8H7FO2 The article contains the following contents:

A hydroxyl radical-mediated aerobic cleavage of alkenes and further sequence esterification reaction for the preparation of carbonyl compounds have been developed by using tubular carbon nitride (TCN) as a general heterogeneous photocatalyst under an oxygen atm. with visible light irradiation This protocol has an excellent substrate scope and gives the desired aldehydes, ketones and esters in moderate to high yields. Importantly, this metal-free procedure employed photogenerated hydroxyl radicals in situ as green oxidation active species, avoiding the present addnl. initiators. The reaction could be carried out under solar light irradiation and was applicable to large-scale reactions. Furthermore, the recyclable TCN catalyst could be used several times without a significant loss of activities.Methyl 4-fluorobenzoate(cas: 403-33-8COA of Formula: C8H7FO2) was used in this study.

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.COA of Formula: C8H7FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rajabi, Fatemeh; Chia, Chin Hua; Sillanpaa, Mika; Voskressensky, Leonid G.; Luque, Rafael published their research in Catalysts in 2021. The article was titled 《Cytosine Palladium Complex Supported on Ordered Mesoporous Silica as Highly Efficient and Reusable Nanocatalyst for One-Pot Oxidative Esterification of Aldehydes》.Application In Synthesis of Methyl 4-fluorobenzoate The article contains the following contents:

The synthesis of esters is one of the most fundamental and significant subjects in organic chem. and chem. industry because they are used in high-value products such as cosmetics, biofuel, pharmaceuticals, surfactants, and food ingredients. In this study, an efficient, economic, sustainable, and green protocol for oxidative esterification reaction has been developed. A one-pot direct transformation of aliphatic, aromatic, and unsaturated aldehydes into esters in the presence of oxygen has been carried out over mesoporous organosilica-supported palladium nanocatalyst (Pd-Cyt@SBA-15) under ambient conditions. Pd-Cyt@SBA-15 efficiently catalyzed selectively large-scale conversion of aldehydes into esters in high yields and large turnover numbers (TON = 98,000). Pd-Cyt@SBA-15 nanocatalyst demonstrated excellent reusability and stability and could be recycled up to ten times without loss of significant reactivity. ICP-AES anal. showed that no leaching of active palladium species occurred during the recycling process of the heterogeneous Pd-Cyt@SBA-15 nanocatalyst. After reading the article, we found that the author used Methyl 4-fluorobenzoate(cas: 403-33-8Application In Synthesis of Methyl 4-fluorobenzoate)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Application In Synthesis of Methyl 4-fluorobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Ni-Catalyzed Denitrogenative Cross-Coupling of Benzotriazinones and Cyclopropanols: An Easy Access to Functionalized β-Aryl Ketones》 was published in Organic Letters in 2020. These research results belong to Li, Jincan; Zheng, Yan; Huang, Mingxian; Li, Wanfang. Related Products of 403-33-8 The article mentions the following:

A novel Ni-catalyzed denitrogenative cross-coupling between benzotriazinones and cyclopropanols is reported herein. This neoteric reactivity allows for the convenient synthesis of β-(o-amido)aryl ketones from readily available starting materials with good yields (up to 93%) and general substrate scope. The results came from multiple reactions, including the reaction of Methyl 4-fluorobenzoate(cas: 403-33-8Related Products of 403-33-8)

Methyl 4-fluorobenzoate(cas: 403-33-8) is an organic fluorinated building block used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of Blonanserin.Related Products of 403-33-8

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics