In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40258-78-4 as follows. Safety of 1-Bromoethyl acetate
[5-(6-Chloro-5-cyano-1-methansulfonyl-1H-indol-2-yl)-6-(2-methoxyethoxymethoxy)biphenyl-3-yloxylacetic acid ethyl ester 260A mixture of 6-chloro-2-[5-hydroxy-2-(2-methoxyethoxymethoxy)biphenyl-3-yl]-1-methansulfonyl-1H-indole-5-carbonitrile (7.0 g, 13 mmoles) and K2CO3 (5.5 g, 23 mmoles) in acetonitrile (200 ml), was mixed with NaI (0.5 g) and bromoethyl acetate (1.6 ml, 14 mmoles). The mixture was stirred for about 18 h at ambient temperature, concentrated, the residue was dissolved in ethyl acetate (400 ml) and washed with brine. The organic layer was dried (MgSO4), filtered and concentrated to afford 8.0 g (98percent) of the title compound as a brown foam.
According to the analysis of related databases, 40258-78-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Axys Pharmaceuticals, Inc.; US6867200; (2005); B1;,
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