Category: 40061-54-9

Application of 40061-54-9, These common heterocyclic compound, 40061-54-9, name is Ethyl 2-(2-chlorophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 35 2-(alpha-ethoxycarbonyl-2-chlorobenzylidene)-1-methylpyrrolidine Follow the procedure of Example 31 to obtain 73.8 g (93percent of theory) of the title compound (b.p. 129° to 0.008 mm of Hg) from 98.4 g of 2-dimethylamino-1-methyl-1-pyrrolinium-methylsulfate, 56.1 g of 2-chlorophenylacetic acid ethyl ester and a solution of 9.5 g of sodium in 190 ml of ethanol.

The synthetic route of 40061-54-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Byk Gulden Lomberg Chemische Fabrik G.m.b.H.; US4279918; (1981); A;,
Ester – Wikipedia,
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Reference of 40061-54-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40061-54-9 as follows.

Step 4. DBU (4.1 g, 26.9 mmol, 1.2 eq) was added to a mixture of 4-(methylamino)-2-(methylthio)-pyrimidine-5-carbaldehyde (4.1 g, 22.4 mmol, 1.0 eq) and ethyl 2-(2-chlorophenyl)acetate (5.4 g, 26.9 mmol, 1.2 eq) at RT. The resulting mixture was then stirred at room temperature for 1 h, followed by addition of water and extraction with EtOAc. The combined organic layers were dried and concentrated to afford 6-(2-chlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (5.0 g, 70percent in yield).

According to the analysis of related databases, 40061-54-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Taunton, JR., John William; Brameld, Kenneth Albert; Goldstein, David Michael; Mcfarland, Jesse; Krishnan, Shyam; Choy, Jonathan; US2014/323464; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40061-54-9, name is Ethyl 2-(2-chlorophenyl)acetate, A new synthetic method of this compound is introduced below., Quality Control of Ethyl 2-(2-chlorophenyl)acetate

o-Chlorotoluene (1.89 g), ethanol (46 mg), di-tert-butyl peroxide (73 mg, 1 equivalent), and Pd(Xantphos)Cl2 (3.8 mg, 1 mol percent) were added into a reaction kettle, into which 10 atm carbon monoxide was introduced. The reaction was heated to 120° C., and stirred at this constant temperature for 16 h. After the reaction was completed, carbon monoxide was discharged, and 82 mg ethyl o-chlorophenylacetate was obtained by column chromatography, in a yield of 83percent. 1HNMR (400 MHz, CDCl3) delta 1.24 (t, J=7.2 Hz, 3H), 3.77 (s, 2H), 4.15 (q, J=7.2 Hz, 2H), 7.21-7.24 (m, 2H), 7.28-7.30 (m, 1H), 7.36-7.40 (m, 1H); 13CNMR (100 MHz, CDCl3) delta 14.2, 39.2, 61.0, 126.9, 128.6, 129.5, 131.4, 132.6, 134.6, 170.6; HRMS (ESI) calcd. for C10H11ClNaO2 [M+Na]: 221.0340. found: 221.0343. The ethyl o-chlorophenylacetate obtained was dissolved in 1,4-dioxane. 6 N sodium hydroxide solution was added, and the reaction was heated to 60° C. After 2 h of reaction, the pH value was adjusted to 1 by adding 2 N hydrochloric acid. After removing the organic solvent under reduced pressure, 66 mg product o-chlorophenylacetic acid was obtained by extraction with ethyl acetate, and the yield of hydrolysis was 94percent.

The synthetic route of 40061-54-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences; Huang, Hanmin; Xia, Chungu; Xie, Pan; US2013/303798; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

40061-54-9, name is Ethyl 2-(2-chlorophenyl)acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C10H11ClO2

1. Take 100 ml of a dry single-mouth flask, and add 2-chloro-phenylacetic acid ethyl ester (1 g, 0.0054 mmol in 10 ml of methanol, then place the system in an ice bath and slowly add lithium aluminum hydride (0.41 g, 0.0108 mmol). ), continue to stir for 1 h after the additionAfter the reaction is completed, a small amount of water is added for quenching.Thereafter, methanol was removed under reduced pressure and extracted with 15 ml of ethyl acetate.After washing with saturated brine, the extract phase was collected and dried over anhydrous sodium sulfate overnight.After the end of drying, the solvent was removed under reduced pressure to give a colorless oil, Compound A,It was used directly in the next reaction without purification.

The synthetic route of 40061-54-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tianjin International Bio-pharmaceutical Joint Institute; Nankai University; Wang Ying; Cai Yan; Mao Yonghong; Guo Yu; Yu Zhenwu; Yang Yang; Zhao Peipei; He Wanli; (10 pag.)CN109897007; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 40061-54-9, name is Ethyl 2-(2-chlorophenyl)acetate, A new synthetic method of this compound is introduced below., COA of Formula: C10H11ClO2

General procedure: Ethyl-2-arylacetate (2 mmol), aq.formaldehyde (1 mmol), aq.ammonia / aliphatic / aromatic amines (2 mmol) and a catalytic amount of piperidine and pyridine in abs. ethanol (250 mL) were refluxed for 4 hour. The course of the reaction was monitored by TLC, and after the disappearance of the starting materials, excess of alcohol is removed in vacuo and the residue extracted with benzene and washed with dil.HCl and then with water and dried. The dried benzene extract was purified by passing through a column of SiO2. The residue obtained on evaporation of the solvent, on crystallization (aq. EtOH) gave pure 3, 5-diarylpiperidin-2, 6-diones in appreciable yields (70-90percent).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Babu, Mariappan; Pitchumani, Kasi; Ramesh, Penugonda; Bioorganic and Medicinal Chemistry Letters; vol. 22; 2; (2012); p. 1263 – 1266;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics