Category: 39987-25-2

Kozik, Violetta; Bak, Andrzej; Pentak, Danuta; Hachula, Barbara; Pytlakowska, Katarzyna; Rojkiewicz, Marcin; Jampilek, Josef; Sieron, Karolina; Jazowiecka-Rakus, Joanna; Sochanik, Aleksander published the artcile< Derivatives of graphene oxide as potential drug carriers>, Recommanded Product: Dimethyl 2,2′-azanediyldiacetate hydrochloride, the main research area is graphene oxide potential drug carrier.

Chem. functionalized graphene oxides could be used as novel drug carriers. Covalent alterations of graphene oxides lead to surface changes via formation of chem. bonding while non-covalent ones involve van der Waals forces, hydrogen bonding, and π-π stacking interactions. Covalent modifications appear to be superior as they can yield compounds with desired properties and carriers prepared by other methods are less stable. Synthesis of graphene oxide-iminodiacetic acid and graphene oxide-glycine involves nucleophilic substitution of graphene oxide nanoparticles with iminodiacetic acid or glycine. As the first step, iminodiacetic acid or glycine were transformed into iminodiacetic acid or glycine Me ester hydrochlorides, resp., for C-terminus protection. The obtained product, activated in situ, was then used to form amide bonds between graphene oxide and iminodiacetic acid or glycine.

Journal of Nanoscience and Nanotechnology published new progress about Amide group. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Recommanded Product: Dimethyl 2,2′-azanediyldiacetate hydrochloride.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Shao, Yujie; Pan, Yue; Li, Yueqing; Wang, Yang; Wang, Liu; Wang, Xu; Shao, Kun; Wang, Shisheng; Liu, Naixuan; Zhang, Jingdong; Zhao, Weijie; Nakamura, Hiroyuki published the artcile< Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy>, Application of C6H12ClNO4, the main research area is hydroxyneolamellarin antitumor agent HIF alpha inhibitor; 7-Hydroxyneolamellarin A; Anti-tumor; HIF-1α inhibition; Total synthesis.

7-Hydroxyneolamellarin A (7-OH-Neo A, 1), a natural marine product derived from sponge Dendrilla nigra, was first synthesized with 10% overall yield under the instruction of convergent synthetic strategy. We found that 7-Hydroxyneolamellarin A could attenuate the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibit vascular epidermal growth factor (VEGF) transcriptional activity, showing well inhibitory effect on HIF-1 signaling pathway. Meantime, 7-Hydroxyneolamellarin A had the well anti-tumor activities, such as inhibiting tumor angiogenesis, proliferation, migration and invasion. More importantly, 7-Hydroxyneolamellarin A exhibited profound anti-tumor effect in mice breast cancer model by suppressing the accumulation of HIF-1α in tumor tissue. Mechanism study demonstrated that 7-Hydroxyneolamellarin A might target the protein with the ability of stabilizing HIF-1α in hypoxia. Due to the excellent water solubility, superior anti-tumor activity and good biocompatibility, 7-OH-Neo A shows the promising potential for being exploited as an anti-tumor agent in near future.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Application of C6H12ClNO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Dong, Huijuan; Ma, Yao; Shao, Kun; Li, Yueqing; Wu, Xiaodan; Wang, Shisheng; Shao, Yujie; Zhao, Weijie published the artcile< Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors>, Computed Properties of 39987-25-2, the main research area is neolamellarin A derivative preparation HIF1 inhibitory activity SAR; Anti-tumor; Hypoxia inducible factor (HIF)-1; Marine alkaloids; Neolamellarin A; Structure-activity relationship.

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A (I) and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, resp. The results showed that neolamellarin A (IC50 = 10.8 ± 1.0 μM) and compound II (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biol. activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small mol. probes for target protein identification.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkaloids Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses) (pyrrole). 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Computed Properties of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hoelzel, Conner A.; Hu, Hang; Wolstenholme, Charles H.; Karim, Basel A.; Munson, Kyle T.; Jung, Kwan Ho; Zhang, Han; Liu, Yu; Yennawar, Hemant P.; Asbury, John B.; Li, Xiaosong; Zhang, Xin published the artcile< A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents>, Reference of 39987-25-2, the main research area is triazole donor acceptor mol substituent; amines; charge transfer; donor-acceptor systems; fluorescence; solvent effects.

While organic donor-acceptor (D-A) mols. are widely employed in multiple areas, the application of more D-A mols. could be limited because of an inherent polarity sensitivity that inhibits photochem. processes. Presented here is a facile chem. modification to attenuate solvent-dependent mechanisms of excited-state quenching through addition of a β-carbonyl-based polar substituent. The results reveal a mechanism wherein the β-carbonyl substituent creates a structural buffer between the donor and the surrounding solvent. Through computational and exptl. analyses, it is demonstrated that the β-carbonyl simultaneously attenuates two distinct solvent-dependent quenching mechanisms. Using the β-carbonyl substituent, improvements in the photophys. properties of commonly used D-A fluorophores and their enhanced performance in biol. imaging are shown.

Angewandte Chemie, International Edition published new progress about Absorption. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Reference of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Jian; Kong, Han-Han; Li, Si-Jia; Zhang, Rui-Jin; Qian, Hao-Dong; Li, Dan-Ran; He, Jin-Yu; Zheng, Yi-Nuo; Xu, Hao published the artcile< Asymmetric copper-catalyzed propargylic amination with amine hydrochloride salts>, Category: esters-buliding-blocks, the main research area is propargylic amination amine hydrochloride salt.

The highly enantioselective copper-catalyzed propargylic amination of propargylic esters with amine hydrochloride salts has been realized for the first time using copper salts with chiral N,N,P-ligands. This method features a broad substrate scope and wide functional group tolerance, generating propargylic amines in good to excellent yields with high enantioselectivities (up to 99% ee). The utility of the approach was demonstrated by late-stage functionalization of marketed pharmaceuticals.

Chemical Communications (Cambridge, United Kingdom) published new progress about Amination. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Dong, Huijuan; Ma, Yao; Shao, Kun; Li, Yueqing; Wu, Xiaodan; Wang, Shisheng; Shao, Yujie; Zhao, Weijie published the artcile< Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors>, Reference of 39987-25-2 , the main research area is neolamellarin A derivative preparation HIF1 inhibitory activity SAR; Anti-tumor; Hypoxia inducible factor (HIF)-1; Marine alkaloids; Neolamellarin A; Structure-activity relationship.

The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. In this work, we designed and synthesized neolamellarin A (I) and its series of derivatives by a convergent synthetic strategy. The HIF-1 inhibitory activity and cytotoxicity of these compounds were evaluated in Hela cells by dual-luciferase reporter gene assay and MTT assay, resp. The results showed that neolamellarin A (IC50 = 10.8 ± 1.0 μM) and compound II (IC50 = 11.9 ± 3.6 μM) had the best HIF-1 inhibitory activity and low cytotoxicity. Our SAR research focused on the effects of key regions aliphatic carbon chain length, aromatic ring substituents and C-7 substituent on biol. activity, providing a basis for the subsequent research on the development of novel pyrrole alkaloids as HIF-1 inhibitors and design of small mol. probes for target protein identification.

Bioorganic & Medicinal Chemistry Letters published new progress about Alkaloids Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses) (pyrrole). 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Reference of 39987-25-2 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Daisuke; Kimura, Hiroyuki; Kawashima, Hidekazu; Yagi, Yusuke; Arimitsu, Kenji; Ono, Masahiro; Saji, Hideo published the artcile< Development of 99mTc radiolabeled A85380 derivatives targeting cerebral nicotinic acetylcholine receptor: Novel radiopharmaceutical ligand 99mTc-A-YN-IDA-C4>, Product Details of C6H12ClNO4, the main research area is technetium 99m A85380 derivative preparation cerebral nicotinic receptor; A85380 derivatives; Docking simulation; Nicotinic acetylcholine receptors; Single-photon emission computed tomography; Technetium-99m.

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that have been implicated in higher brain functions. To elucidate the functional mechanisms underlying nAChRs and contribute significantly to development of drugs targeting neurol. and neuropsychiatric diseases, non-invasive nuclear medical imaging can be used for evaluation. In addition, technetium-99m (99mTc) is a versatile radionuclide used clin. as a tracer in single-photon emission computed tomog. Because A85380 is known as a potent α4β2-nAChR agonist, we prepared A85380 derivatives labeled with 99mTc using a bifunctional chelate system. A computational scientific approach was used to design the probe efficiently. We used non-radioactive rhenium (Re) for a 99mTc analog and found that one of the derivatives, Re-A-YN-IDA-C4, exhibited high binding affinity at α4β2-nAChR in both the docking simulation (-19.3 kcal/mol) and binding assay (Ki = 0.4 ± 0.04 nM). Further, 99mTc-A-YN-IDA-C4 was synthesized using microwaves, and its properties were examined Consequently, we found that 99mTc-A-YN-IDA-C4, with a structure optimized by using computational chem. techniques, maintained affinity and selectivity for nAChR in vitro and possessed efficient characteristics as a nuclear medicine mol. imaging probe, demonstrated usefulness of computational scientific approach for mol. improvement strategy.

Bioorganic & Medicinal Chemistry published new progress about Brain. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Product Details of C6H12ClNO4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Guangzhe; Shao, Yujie; Pan, Yue; Li, Yueqing; Wang, Yang; Wang, Liu; Wang, Xu; Shao, Kun; Wang, Shisheng; Liu, Naixuan; Zhang, Jingdong; Zhao, Weijie; Nakamura, Hiroyuki published the artcile< Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy>, Related Products of 39987-25-2, the main research area is hydroxyneolamellarin antitumor agent HIF alpha inhibitor; 7-Hydroxyneolamellarin A; Anti-tumor; HIF-1α inhibition; Total synthesis.

7-Hydroxyneolamellarin A (7-OH-Neo A, 1), a natural marine product derived from sponge Dendrilla nigra, was first synthesized with 10% overall yield under the instruction of convergent synthetic strategy. We found that 7-Hydroxyneolamellarin A could attenuate the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibit vascular epidermal growth factor (VEGF) transcriptional activity, showing well inhibitory effect on HIF-1 signaling pathway. Meantime, 7-Hydroxyneolamellarin A had the well anti-tumor activities, such as inhibiting tumor angiogenesis, proliferation, migration and invasion. More importantly, 7-Hydroxyneolamellarin A exhibited profound anti-tumor effect in mice breast cancer model by suppressing the accumulation of HIF-1α in tumor tissue. Mechanism study demonstrated that 7-Hydroxyneolamellarin A might target the protein with the ability of stabilizing HIF-1α in hypoxia. Due to the excellent water solubility, superior anti-tumor activity and good biocompatibility, 7-OH-Neo A shows the promising potential for being exploited as an anti-tumor agent in near future.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Related Products of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mori, Daisuke; Kimura, Hiroyuki; Kawashima, Hidekazu; Yagi, Yusuke; Arimitsu, Kenji; Ono, Masahiro; Saji, Hideo published the artcile< Development of 99mTc radiolabeled A85380 derivatives targeting cerebral nicotinic acetylcholine receptor: Novel radiopharmaceutical ligand 99mTc-A-YN-IDA-C4>, Reference of 39987-25-2, the main research area is technetium 99m A85380 derivative preparation cerebral nicotinic receptor; A85380 derivatives; Docking simulation; Nicotinic acetylcholine receptors; Single-photon emission computed tomography; Technetium-99m.

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that have been implicated in higher brain functions. To elucidate the functional mechanisms underlying nAChRs and contribute significantly to development of drugs targeting neurol. and neuropsychiatric diseases, non-invasive nuclear medical imaging can be used for evaluation. In addition, technetium-99m (99mTc) is a versatile radionuclide used clin. as a tracer in single-photon emission computed tomog. Because A85380 is known as a potent α4β2-nAChR agonist, we prepared A85380 derivatives labeled with 99mTc using a bifunctional chelate system. A computational scientific approach was used to design the probe efficiently. We used non-radioactive rhenium (Re) for a 99mTc analog and found that one of the derivatives, Re-A-YN-IDA-C4, exhibited high binding affinity at α4β2-nAChR in both the docking simulation (-19.3 kcal/mol) and binding assay (Ki = 0.4 ± 0.04 nM). Further, 99mTc-A-YN-IDA-C4 was synthesized using microwaves, and its properties were examined Consequently, we found that 99mTc-A-YN-IDA-C4, with a structure optimized by using computational chem. techniques, maintained affinity and selectivity for nAChR in vitro and possessed efficient characteristics as a nuclear medicine mol. imaging probe, demonstrated usefulness of computational scientific approach for mol. improvement strategy.

Bioorganic & Medicinal Chemistry published new progress about Brain. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Reference of 39987-25-2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hoelzel, Conner A.; Hu, Hang; Wolstenholme, Charles H.; Karim, Basel A.; Munson, Kyle T.; Jung, Kwan Ho; Zhang, Han; Liu, Yu; Yennawar, Hemant P.; Asbury, John B.; Li, Xiaosong; Zhang, Xin published the artcile< A General Strategy to Enhance Donor-Acceptor Molecules Using Solvent-Excluding Substituents>, Safety of Dimethyl 2,2′-azanediyldiacetate hydrochloride, the main research area is triazole donor acceptor mol substituent; amines; charge transfer; donor-acceptor systems; fluorescence; solvent effects.

While organic donor-acceptor (D-A) mols. are widely employed in multiple areas, the application of more D-A mols. could be limited because of an inherent polarity sensitivity that inhibits photochem. processes. Presented here is a facile chem. modification to attenuate solvent-dependent mechanisms of excited-state quenching through addition of a β-carbonyl-based polar substituent. The results reveal a mechanism wherein the β-carbonyl substituent creates a structural buffer between the donor and the surrounding solvent. Through computational and exptl. analyses, it is demonstrated that the β-carbonyl simultaneously attenuates two distinct solvent-dependent quenching mechanisms. Using the β-carbonyl substituent, improvements in the photophys. properties of commonly used D-A fluorophores and their enhanced performance in biol. imaging are shown.

Angewandte Chemie, International Edition published new progress about Absorption. 39987-25-2 belongs to class esters-buliding-blocks, and the molecular formula is C6H12ClNO4, Safety of Dimethyl 2,2′-azanediyldiacetate hydrochloride.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics