Category: 3976-69-0

On February 28, 2015, Venkataraman, Sowmyalakshmi; Chadha, Anju published an article.Reference of (R)-Methyl 3-hydroxybutanoate The title of the article was Biocatalytic deracemization of aliphatic β-hydroxy esters: Improving the enantioselectivity by optimization of reaction parameters. And the article contained the following:

Optically pure aliphatic β-hydroxy esters were prepared from their racemates by deracemization using the biocatalyst Candida parapsilosis ATCC 7330. High optical purity (up to >99 %) and good yields (up to 71 %) of the product secondary alcs. were obtained. This study highlights the importance of optimization of reaction conditions using ethyl-3-hydroxybutanoate as the model substrate to improve the enantioselectivity (enantiomeric excess from 9 to 98 %). The present study emphasizes the broad substrate scope of the biocatalyst towards deracemization. This is the first report of Candida parapsilosis ATCC 7330-mediated deracemization of various alkyl-3-hydroxybutanoates to produce either the (R)-enantiomers (Me, Et, Pr, Bu, t-Bu, allyl-3-hydroxybutanoates) or (S)-enantiomers (pentyl, iso-amyl and iso-propyl-3-hydroxybutanoates). The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Reference of (R)-Methyl 3-hydroxybutanoate

The Article related to hydroxy ester beta biocatalytic deracemization candida parapsilosis, Aliphatic Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Reference of (R)-Methyl 3-hydroxybutanoate

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Ester – an overview | ScienceDirect Topics

Ramesh, Perla; Fadnavis, Nitin W. published an article in 2015, the title of the article was Ammonium nitrate: a biodegradable and efficient catalyst for the direct amidation of esters under solvent-free conditions.Recommanded Product: 3976-69-0 And the article contains the following content:

Metal-free and environment-friendly procedure was developed for the direct conversion of esters to amides using ammonium nitrate as a catalyst under solvent-free conditions. Aryls, heteroaryls, and aliphatic esters were easily converted to the corresponding amides in excellent isolated yields (85-99%). An enantiopure ester and amine were both shown to react without racemization. The methodol. was successfully applied to preparation of procainamide. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Recommanded Product: 3976-69-0

The Article related to ester amine ammonium nitrate catalyst amidation, amide preparation green chem, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Recommanded Product: 3976-69-0

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Ester – an overview | ScienceDirect Topics

Huang, Shuangping; Liu, Dongwang; Tang, Linjun; Huang, Fei Fei; Zhang, Jianting; Wang, Xiaoji published an article in 2015, the title of the article was Total Synthesis of (+)-7-Epi-tarchonanthuslactone via a Chelation-Controlled Mukaiyama Aldol Reaction.Recommanded Product: 3976-69-0 And the article contains the following content:

An asym. total synthesis of (+)-7-epi-tarchonanthuslactone (I) was achieved from com. available Me (R)-3-hydroxybutyrate. The key step employed a diastereoselective chelation-controlled Mukaiyama aldol reaction to construct the chiral hydroxyl group at the C-5 position. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Recommanded Product: 3976-69-0

The Article related to tarchonanthuslactone synthesis diastereoselective mukaiyama aldol, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Recommanded Product: 3976-69-0

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

He, Tian-Jun; Zhu, Shijun; Lu, Xiao-Wei; Wu, Yikang; Li, Yan published an article in 2015, the title of the article was Absolute Configurations of Melanoxadin, MR-93A, Melanoxazal, and MR-93B.Computed Properties of 3976-69-0 And the article contains the following content:

Fungal metabolites melanoxadin, MR-93A, melanoxazal and MR-93B were synthesized with the key stereogenic centers derived from com. available chiral building blocks. The optically active synthetic products with well-defined absolute configurations provided authentic samples for the stereoisomers of these oxazole-containing natural products and thus allowed for unambiguous assignments of their relative and absolute configurations. The large discrepancies in the optical rotations between the natural and the pure synthetic samples are discussed. Some errors in the previously reported NMR signal assignments are also corrected The synthesis of the target compounds was achieved using (2S)-2-hydroxypropanoic acid Et ester and (3S)-3-hydroxybutanoic acid, (3R)-3-hydroxybutanoic acid as chiral source materials. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Computed Properties of 3976-69-0

The Article related to melanoxadin melanoxazal fungus metabolite preparation configuration, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Computed Properties of 3976-69-0

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2015, Huang, Shuangping; Liu, Dongwang; Tang, Linjun; Huang, Feifei; Yang, Wei; Wang, Xiaoji published an article.Recommanded Product: 3976-69-0 The title of the article was A Concise and Versatile Total Synthesis of All Stereoisomers of Tarchonanthuslactone. And the article contained the following:

We describe the versatile and concise total synthesis of all stereoisomers of tarchonanthuslactone from (R)- or (S)-3-hydroxybutyrate via eight steps. The key steps of the synthesis include a highly diastereoselective chelation-controlled Mukaiyama aldol reaction of a p-methoxybenzyl-protected aldehyde and a Yamaguchi lactonization of a δ-hydroxy-trans-α,β-unsaturated carboxylic acid. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Recommanded Product: 3976-69-0

The Article related to tarchonanthuslactone synthesis mukaiyama aldol yamaguchi lactonization, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Recommanded Product: 3976-69-0

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Veena, Bacchu; Sharma, Gangavaram V. M. published an article in 2014, the title of the article was Stereoselective synthesis of macrosphelide I.Recommanded Product: (R)-Methyl 3-hydroxybutanoate And the article contains the following content:

An efficient total synthesis of (4R,7E,9R,10S,15R,16S)-9,15-dihydroxy-4,10,16-trimethyl-1,5,11-trioxacyclohexadec-7-ene-2,6,12-trione (macrosphelide I) has been achieved starting from com. available chiral materials, Et (S)-lactate and Me (R)-3-hydroxybutyrate. The synthesis of the target compound was carried out by a titanium(IV) promoted regioselective nucleophilic opening reaction of epoxy alc. with benzoic acid, Sharpless epoxidation, ring-closing metathesis and Yamaguchi esterification as key steps for the construction of the 16-membered macrotriolide. (2E,4S)-4-[(4-Methoxyphenyl)methoxy]-2-penten-1-ol was used as a starting material. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Recommanded Product: (R)-Methyl 3-hydroxybutanoate

The Article related to macrosphelide preparation total synthesis cytotoxic anticancer antitumor agent, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Recommanded Product: (R)-Methyl 3-hydroxybutanoate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 15, 2016, Choliq, Azka Azkiya; Watanabe, Junya; Misaki, Tomonori; Okamoto, Yasuaki; Sugimura, Takashi published an article.HPLC of Formula: 3976-69-0 The title of the article was Enantioselective hydrogenation of β-aryl-β-ketoester over α-hydroxy acid-modified Raney nickel catalysts: competitive hydrogenation with methyl acetoacetate. And the article contained the following:

The enantioselective hydrogenation of the aromatic β-ketoesters, Me 3-phenyl-3-oxopropanoate (1) and its p-methoxy analog (2), was studied over tartaric acid-modified Raney nickel catalysts. A competitive hydrogenation approach was used to clarify the catalytic behaviors of the enantio-differentiating hydrogenation of aromatic β-ketoesters over tartaric acid-modified Raney nickel, malic acid-modified Raney nickel, and unmodified Raney nickel in comparison with aliphatic one, represented by Me acetoacetate. The authors found that the enantioselectivity could be elucidated by the interaction modes between the surface modifier, Ni metal surface, and the substrate as well as the keto/enol ratio of the substrate. The authors suggest that the moderate enantioselectivity of 1 over tartaric acid-modified Raney nickel is the result of distorted, weak two-point hydrogen bond interactions with surface tartrate due to unfavorable phenyl-Ni metal surface interactions. The p-methoxy group of 2 suppresses the phenyl-Ni metal surface interactions, resulting in an increase in the enantioselectivity of 2 over tartaric acid-modified Raney nickel. Ligand acceleration effects were observed with Me acetoacetate and 2 but not with 1. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).HPLC of Formula: 3976-69-0

The Article related to aryl keto ester enantioselective hydrogenation tartaric acid nickel catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.HPLC of Formula: 3976-69-0

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Okuno, Yoshinori; Isomura, Shigeki; Nishibayashi, Akihiro; Hosoi, Aiko; Fukuyama, Kei; Ohba, Masashi; Takeda, Kazuyoshi published an article in 2014, the title of the article was Modified Yamaguchi Reagent: Convenient and Efficient Esterification.COA of Formula: C5H10O3 And the article contains the following content:

A convenient and efficient esterification method that used a modified Yamaguchi reagent {2,4,6-trichlorobenzoyl chloride-4-(dimethylamino)pyridine} and avoided the use not only of intractable acid chloride but also of acid anhydrides was proposed. Thus, reacting R1CO2H [R1 = Ph(CH2)2, Ph, (E)-PhCH:CH] with R2OH [R2 = (-)-menthyl, Bn, 1-phenylethyl, (E)-cinnamyl] gave R1CO2R2 in good to excellent yields. The reaction mechanism was described by Fourier transform IR spectroscopy and supported by a d. functional theory calculation The reaction was applied to the synthesis of a Linyphia triangularis pheromone, I. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).COA of Formula: C5H10O3

The Article related to esterification acid alc yamaguchi reagent trichlorobenzoyl chloride dimethylaminopyridine, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.COA of Formula: C5H10O3

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On May 10, 2018, Yu, Wensheng; Tong, Ling; Selyutin, Oleg; Chen, Lei; Hu, Bin; Zhong, Bin; Hao, Jinglai; Ji, Tao; Zan, Shuai; Yin, Jingjun; Ruck, Rebecca T.; Curry, Stephanie; McMonagle, Patricia; Agrawal, Sony; Rokosz, Laura; Carr, Donna; Ingravallo, Paul; Bystol, Karin; Lahser, Frederick; Liu, Rong; Chen, Shiying; Feng, Kung-I.; Cartwright, Mark; Asante-Appiah, Ernest; Kozlowski, Joseph A. published an article.Computed Properties of 3976-69-0 The title of the article was Discovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions. And the article contained the following:

We describe the discovery of MK-6169 (I), a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal carbon region of elbasvir led to the discovery of a series of compounds with substantially improved potency against common resistance-associated substitutions in the major genotypes, as well as good pharmacokinetics in both rat and dog. Through further optimization of key leads from this effort, MK-6169 (I) was discovered as a preclin. candidate for further development. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Computed Properties of 3976-69-0

The Article related to imidazolylbenzooxazinoindole preparation mk6169 antiviral hepatitis c virus ns5a inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Computed Properties of 3976-69-0

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tanasova, Marina; Anyika, Mercy; Borhan, Babak published an article in 2015, the title of the article was Sensing Remote Chirality: Stereochemical Determination of β-, γ-, and δ-Chiral Carboxylic Acids.Name: (R)-Methyl 3-hydroxybutanoate And the article contains the following content:

Determining the absolute stereochem. of small mols. bearing remote nonfunctionalizable stereocenters is a challenging task. Presented is a solution in which appropriately substituted bis(porphyrin) tweezers are used. Complexation of a suitably derivatized β-, γ-, or δ-chiral carboxylic acid to the tweezer induces a predictable helicity of the bis(porphyrin), which is detected as a bisignate Cotton Effect (ECCD). The sign of the ECCD curve is correlated with the absolute stereochem. of the substrate based on the derived working mnemonics in a predictable manner. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Name: (R)-Methyl 3-hydroxybutanoate

The Article related to sensing remote chirality stereochem chiral carboxylic acid, chirality, circular dichroism, host-guest systems, stereochemistry, zinc, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Name: (R)-Methyl 3-hydroxybutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics