Category: 3976-69-0

On February 29, 2012, Curran, Dennis P.; Sinha, Mantosh K.; Zhang, Kai; Sabatini, Jesse J.; Cho, Dae-Hyun published an article.Recommanded Product: 3976-69-0 The title of the article was Binary fluorous tagging enables the synthesis and separation of a 16-stereoisomer library of macrosphelides. And the article contained the following:

Fluorous mixture synthesis minimizes the effort to synthesize small-mol. libraries by labeling the mols. rather than the reaction vessels. Reactants are labeled with fluorinated tags and products can later be demixed based on the fluorine content. A limit in the number of available tags can be overcome by using binary encoding so that a total of four tags can label uniquely a library of 16 compounds This strategy, however, means that separation based on fluorine content alone is not possible. Here, we solve this problem by selectively removing one tag after an initial demixing step; a second demixing provides each individual compound The usefulness of this strategy is demonstrated by the synthesis of a library that contains all 16 diastereomers of the natural products macrosphelides A and E. Macrosphelide D was not in this library, and so its assigned structure was incorrect. We determined its constitution by using NMR spectroscopy and its configuration by synthesizing four candidate stereoisomers. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Recommanded Product: 3976-69-0

The Article related to macrosphelide stereoisomer library preparation binary fluorous tagging, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Recommanded Product: 3976-69-0

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On March 31, 2012, Curran, Dennis P.; Sinha, Mantosh K.; Zhang, Kai; Sabatini, Jesse J.; Cho, Dae-Hyun published an article.Name: (R)-Methyl 3-hydroxybutanoate The title of the article was Binary fluorous tagging enables the synthesis and separation of a 16-stereoisomer library of macrosphelides [Erratum to document cited in CA156:230324]. And the article contained the following:

On page 129, it erroneously stated the authors had no competing financial interests; the HTML and PDF versions have been corrected The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Name: (R)-Methyl 3-hydroxybutanoate

The Article related to erratum macrosphelide stereoisomer library preparation binary fluorous tagging, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Name: (R)-Methyl 3-hydroxybutanoate

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Ester – Wikipedia,
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Osawa, Tsutomu; Kizawa, Tomoko; Takano, Fumika; Ikeda, Shinji; Kitamura, Takayuki; Inoue, Yoshihisa; Borovkov, Victor published an article in 2014, the title of the article was Catalytic Enantiodifferentiating Hydrogenation with Commercial Nickel Powders Chirally Modified by Tartaric Acid and Sodium Bromide.Formula: C5H10O3 And the article contains the following content:

The chirally modified nickel catalysts for the enantiodifferentiating hydrogenation of β-ketoesters are prepared conventionally by immersing hydrogen-activated metallic nickel into an aqueous solution of enantiopure tartaric acid, in which the preactivation of nickel is essential. Herein, we revealed that even com. available nickel powders without any pretreatment can catalyze the enantiodifferentiating hydrogenation of β-ketoesters to give the corresponding β-hydroxyesters in quant. yield and high enantioselectivity (up to 91%) under optimized conditions. The immediate use of com. available nickel powders and the reproducible high chem. and optical yields not only expand the scope of heterogeneous asym. catalysis but also pave the way for the practical application and industrial use of chirally modified nickel catalysts. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Formula: C5H10O3

The Article related to methyl hydroxybutyrate enantioselective synthesis, ketoester hydrogenation tartaric acid modified nickel sodium bromide, Aliphatic Compounds: Esters, Linear Anhydrides, Acyl Peroxides, and Acyl Halides and other aspects.Formula: C5H10O3

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Ester – an overview | ScienceDirect Topics

Chatare, Vijay K.; Andrade, Rodrigo B. published an article in 2017, the title of the article was Total Synthesis of (-)-Albocycline.Product Details of 3976-69-0 And the article contains the following content:

The macrolactone natural product (-)-albocycline (I) is a promising antibiotic candidate for the treatment of both methicillin resistant Staphylococcus aureus (MRSA) and vancomycin-resistant strains. Herein, we report a concise total synthesis of (-)-albocycline in 14 steps from com. available Me (R)-3-hydroxybutyrate. Novel key steps include the highly regio- and stereoselective reactions of chiral N-sulfinyl metallodienamines (NSMDs) with aldehydes and the Davis oxaziridine, in addition to the Horner-Wadsworth-Emmons olefination of N-sulfinyl imines. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Product Details of 3976-69-0

The Article related to albocycline total synthesis regioselective stereoselective, n-sulfinyl metallodienamine, albocycline, antibiotics, total synthesis, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Product Details of 3976-69-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 30, 2017, Katsuta, Ryo; Masada, Naoko; Shimodaira, Yuichiro; Ueda, Saeko; Yajima, Arata; Nukada, Tomoo published an article.COA of Formula: C5H10O3 The title of the article was Synthesis and stereochemistry of decarestrictines H and J. And the article contained the following:

The first synthesis of (7S,9R)-decarestrictine H and (7R,9R)-decarestrictine H as well as the improved synthesis of decarestrictine J were achieved. The overall yields of (7S,9R)-decarestrictines H and J were 20.9% each in nine to ten steps from (R)-Roche ester using a unified synthetic route via esterification with 3,3-ethylenedioxyhex-5-enoic acid and ring-closing metathesis, which were the key steps. The relative stereochem. of decarestrictine H was determined to be 7,9-syn by comparing the spectral data of the natural product and synthetic epimers of decarestrictines H. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).COA of Formula: C5H10O3

The Article related to decarestrictine h j synthesis stereochem, esterification synthesis decarestrictine h j, ring closing metathesis synthesis decarestrictine h j, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.COA of Formula: C5H10O3

Referemce:
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Ester – an overview | ScienceDirect Topics

Brown, Christopher A.; Aggarwal, Varinder K. published an article in 2015, the title of the article was Short Convergent Synthesis of the Mycolactone Core Through Lithiation-Borylation Homologations.Formula: C5H10O3 And the article contains the following content:

Using iterative lithiation-borylation homologations, the mycolactone toxin core (I) has been synthesized in 13 steps and 17% overall yield. The rapid build-up of mol. complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Formula: C5H10O3

The Article related to mycolactone core preparation stereoselective lithiation borylation homologation, asymmetric synthesis, boron, iterative homologation, mycolactone, natural products, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Formula: C5H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2020, Arrigo, Rosa; Gallarati, Simone; Schuster, Manfred E.; Seymour, Jake M.; Gianolio, Diego; da Silva, Ivan; Callison, June; Feng, Haosheng; Proctor, John E.; Ferrer, Pilar; Venturini, Federica; Grinter, David; Held, Georg published an article.Related Products of 3976-69-0 The title of the article was Influence of Synthesis Conditions on the Structure of Nickel Nanoparticles and their Reactivity in Selective Asymmetric Hydrogenation. And the article contained the following:

Unsupported and SiO2-supported Ni nanoparticles (NPs) were synthesized via hot-injection colloidal route using oleylamine (OAm) and trioctylphosphine (TOP) as reducing and protective agents, resp. By adopting a multi-length scale(coating process) structural characterization, it was found that by changing equivalent of OAm and TOP not only the size of the nanoparticles is affected but also the Ni electronic structure. The synthesized NPs were modified with (R,R)-tartaric acid (TA) and investigated in the asym. hydrogenation of Me acetoacetate to chiral methyl-3-hydroxy butyrate. The comparative anal. of structure and catalytic performance for the synthesized catalysts has enabled us to identify a Ni metallic active surface, whereby the activity increases with the size of the metallic domains. Conversely, at the high conversion obtained for the unsupported NPs there was no impact of particle size on the selectivity. (R)-selectivity was very high only on catalysts containing pos. charged Ni species such as over the SiO2-supported NiO NPs. This work shows that the chiral modification of metallic Ni NPs with TA is insufficient to maintain high selectivity towards the (R)-enantiomer at long reaction times and provides guidance for the engineering of long-term stable enantioselective catalysts. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Related Products of 3976-69-0

The Article related to nickel nanoparticle asym hydrogenation, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Reaction Kinetics and other aspects.Related Products of 3976-69-0

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On November 11, 2014, Tabata, Yuta; Abe, Hideki published an article.Electric Literature of 3976-69-0 The title of the article was Synthesis and Properties of Alternating Copolymers of 3-Hydroxybutyrate and Lactate Units with Different Stereocompositions. And the article contained the following:

Alternating copolymers of (R)-3-hydroxybutyrate ((R)-3HB) and lactate (2-hydroxypropionate: 2HP) units were synthesized by polycondensation reaction of preprepared dimeric monomers, (R)-3HB-(R)-2HP and (R)-3HB-(S)-2HP, in the presence of condensation agent. On the basis of the NMR analyses, it was confirmed that the obtained copolymers had an alternating sequence of (R)-3HB and 2HP units. In contrast to random copolymers of (R)-3HB and 2HP units, the repeating sequence of alternately connected (R)-3HB and 2HP units formed crystalline region. The copolymer with alternating sequence of (R)-3HB and (S)-2HP units had a melting temperature at 83 °C. On the other hands, the melting temperature of copolymer of (R)-3HB and (R)-2HP units was quite higher than those of the corresponding homopolymers (around 180 °C) and reached to 233 °C. When the alternating copolymers were prepared from a mixture of stereoisomeric dimers, both the melting temperature and crystallinity varied in the wide ranges depending on the composition of stereoisomeric dimers. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Electric Literature of 3976-69-0

The Article related to hydroxybutyrate lactate alternating copolymer synthesis stereoisomeric dimer, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Electric Literature of 3976-69-0

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 30, 2013, Tabata, Yuta; Abe, Hideki published an article.Application In Synthesis of (R)-Methyl 3-hydroxybutanoate The title of the article was Effects of composition and sequential structure on thermal properties for copolymer of 3-hydroxybutyrate and lactate units. And the article contained the following:

Copolymers of (R)-3-hydroxybutyrate (3HB) and (R)-lactate ((R)-2-hydroxypropionate: 2HP) units were synthesized by polycondensation reaction from Me esters of 3HB and 2HP in the presence of titanium-based catalyst. Mixing of two monomers from the beginning of polymerization yielded random copolymers of 3HB and 2HP units. On the other hand, by controlling the time of mixing of two monomers, copolymers with blocking tendency were obtained. The structure and thermal properties of the obtained copolymers were characterized by 1H and 13C NMR, x-ray diffraction, differential scanning calorimetry, and optical microscopy. Glass-transition temperature of the copolymers was mainly governed by the copolymer composition, and the values varied linearly with the composition In contrast, the melting temperature was strongly depending on the sequential length of crystallizable monomeric unit, and the values were in inverse proportion to the number-averaged sequential length of crystallizable monomeric unit. The crystallinity of the copolymer samples was affected by both the composition and sequential length of crystallizable monomeric unit. The finding is valuable for design of copolymer mols. with desirable thermal properties by controlling both the copolymer composition and sequential structure. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Application In Synthesis of (R)-Methyl 3-hydroxybutanoate

The Article related to hydroxybutyrate lactate copolymer synthesis thermal property, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Application In Synthesis of (R)-Methyl 3-hydroxybutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 2, 2014, Anderson, Katie; Laclef, Sylvain; Barrett, Anthony G. M. published an article.Reference of (R)-Methyl 3-hydroxybutanoate The title of the article was Mechanistic studies of highly regioselective decarboxylative-prenyl migration reactions of prenyloxycarbonyl-diketo-dioxinones. And the article contained the following:

Mechanistic studies of tandem regioselective decarboxylation, prenyl transfer, and aromatization reactions of prenyl dioxinone diketo-carboxylates to provide 3-prenyl-resorcylate derivatives are described. Studies of the effects of concentration and the base employed as well as the results of cross-over experiments were all found to be consistent with the reaction proceeding largely via an intermol. reaction pathway. The experimental process involved the reaction of (R)-Methyl 3-hydroxybutanoate(cas: 3976-69-0).Reference of (R)-Methyl 3-hydroxybutanoate

The Article related to mechanistic regioselective decarboxylative prenyl migration prenyloxycarbonyl diketodioxinone crystallog, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Reference of (R)-Methyl 3-hydroxybutanoate

Referemce:
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Ester – an overview | ScienceDirect Topics