Category: 39552-81-3

Synthetic Route of 39552-81-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39552-81-3 as follows.

EXAMPLE 3 N-(4-Methoxycarbonylmethylphenyl)-L-glutamine: Compound (3) Following the procedure described in (a) of Example 1, 11.14 g (0.03 mole) of N-carbobenzoxy-L-glutamic acid alpha-benzyl ester was reacted with 4.96 g (0.03 mole) of methyl p-aminophenylacetate to give 13.38 g (88% yield) of an intermediate. The intermediate was dissolved in 500 ml of tetrahydrofuran, 200 ml of methanol and 100 ml of water. To the solution was added 0.5 g of palladium black and the mixture was subjected to hydrogenation at atmospheric pressure to give 6.09 g (79% yield) of N-(4-methoxycarbonylmethylphenyl)-L-glutamine, m.p. 183.3-184.2 C. [alpha]D25 =+29.2 (c=1 2 N HCl)

According to the analysis of related databases, 39552-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Chemical Industries Ltd.; Nippon Shinyaku Co., Ltd.; US4439448; (1984); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 39552-81-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 39552-81-3 as follows.

EXAMPLE 3 N-(4-Methoxycarbonylmethylphenyl)-L-glutamine: Compound (3) Following the procedure described in (a) of Example 1, 11.14 g (0.03 mole) of N-carbobenzoxy-L-glutamic acid alpha-benzyl ester was reacted with 4.96 g (0.03 mole) of methyl p-aminophenylacetate to give 13.38 g (88% yield) of an intermediate. The intermediate was dissolved in 500 ml of tetrahydrofuran, 200 ml of methanol and 100 ml of water. To the solution was added 0.5 g of palladium black and the mixture was subjected to hydrogenation at atmospheric pressure to give 6.09 g (79% yield) of N-(4-methoxycarbonylmethylphenyl)-L-glutamine, m.p. 183.3-184.2 C. [alpha]D25 =+29.2 (c=1 2 N HCl)

According to the analysis of related databases, 39552-81-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Mitsubishi Chemical Industries Ltd.; Nippon Shinyaku Co., Ltd.; US4439448; (1984); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39552-81-3, name is Methyl 2-(4-aminophenyl)acetate, A new synthetic method of this compound is introduced below., Product Details of 39552-81-3

A solution of chloride 19 (992 mg, 5 5 mmol) and aniline 50 (1.99 g, 12.0 mmol) in DMSO (30 mL) was heated at 100 C for 6 h and then 20 C for 16 h. The solution was partitioned between EtOAc (200 mL) and water (200 mL), the organic fraction washed with water (2 x 100 mL), dried, and the solvent evaporated. The residue was chromatographed, eluting with 10% EtOAc/DCM, to give the 1-oxide 51 (1.05 g, 61%) as a yellow solid, mp (EtOAc/DCM) 216-218 C; 1H NMR [(CD3)2SO] delta 10.00 (s, 1 H, NH), 8.24 (d, J = 8 3 Hz, 1 H, H-8″), 7.82 (d, J = 8.4 Hz, 2 H, H-2′, H-6′), 7.79 (dd, J = 8.2, 7.3 Hz, 1 H, H-6″), 7.70 (d, J = 8 2 Hz, 1 H, H-5″), 7.40 (dd, J = 8.3, 7.3 Hz, 1 H, H-7″), 7.22 (d, J = 8 4 Hz, 2 H, H-3′, H-5′), 3.67 (s, 3 H, OCH3), 3.60 (s, 2 H, H-2), 13C NMR [(CD3)2SO] delta 171.7 (C-1), 156.3 (C-3″), 147.9 (C-4a”), 138.1 (C-4′), 135.6 (C-6″), 131.9 (C-8a”), 129.4 (C-2′, C-6′), 128.3 (C-1′), 126.7 (C-5″), 125.5 (C-7″), 119.9 (C-8″), 119.7 (C-3′, C-5′), 51.7 (OCH3), 40.1 (C-2); Anal. calc. for C16H14N4O3: C, 61 9; H, 4.6; N, 18.1; found C, 62 3; H, 4.8; N, 18.1 %.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Auckland Uniservices Limited; EP1468688; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 39552-81-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39552-81-3, name is Methyl 2-(4-aminophenyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 100 9-Bromo-5-(p-methoxycarbonylmethylphenylcarbamoylmethyl)-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione A procedure similar to that described in Example 52 was carried out with 9-bromo-5-carboxymethyl-6,7-dihydro-1H, 5H-pyrido[1,2,3-de]quinoxaline-2,3-dione (340 mg, 1 mmol) and p-methoxycarbonylmethylaniline (215 mg, 1.3 mmol) to give 395 mg of the title compound (81%): mp 262 C. (dec); 1 H NMR (270 MHz, DMSO-d6) delta10.02 (s, 1H), 7.50 (d, 2H, J=8.3 Hz), 7.23 (bs, 1H), 7.18 (d, 2H, J=8.3 Hz), 7.17 (bs, 1H), 5.17~5.26 (m, 1H), 3.61~3.62 (m, 5H), 3.06 (ddd, 1H, J=17.1, 13.5, 4.5 Hz), 2.84 (dm, 1H, J=17.1 Hz),2.56~2.66 (m, 2H), 2.11 (dm, 1H, J=13.5 Hz), 1.76~1.94 (m, 1H).

The synthetic route of Methyl 2-(4-aminophenyl)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; US5616586; (1997); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics