Regio- and enantioselective reduction of 浼?2-dioxocycloalkaneacetates with fermenting baker’s yeast. A new synthesis of (R)-(-)-hexahydromandelic acid was written by Tsuboi, Sadao;Nishiyama, Emiko;Furutani, Hiroyuki;Utaka, Masanori;Takeda, Akira. And the article was included in Journal of Organic Chemistry in 1987.Safety of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate This article mentions the following:
Reduction of 浼?2-dioxocycloalkaneacetic acid esters with fermenting baker’s yeast gives optically active (R)-浼?hydroxy-2-oxocycloalkaneacetic acid esters in 34-74% yield. Reduction of Et 浼?2-dioxocyclohexaneacetate gave Et (浼?em>R)-浼?hydroxy-2-oxocyclohexaneacetate (I) as a mixture of threo and erythro isomers (9:1) with 99% optical purity. Clemmensen reduction of I and subsequent hydrolysis gave optically pure (R)-(-)-hexahydromandelic acid. Treatment of Me (1R,5R)-浼?[6,6-dimethyl-2-oxo[3.1.1]bicycloheptan-3-yl]-浼?oxoacetate with bakers’ yeast also afforded the resp. 浼?hydroxy acetate in 32% yield. In the experiment, the researchers used many compounds, for example, Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate (cas: 39163-39-8Safety of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate).
Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate (cas: 39163-39-8) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Safety of Ethyl 2-oxo-2-(2-oxocyclopentyl)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics