Category: 39149-80-9

Reference of 39149-80-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39149-80-9, name is tert-Butyl 2-bromopropanoate, This compound has unique chemical properties. The synthetic route is as follows.

yl)propanoate (R)-6-chloro-4-(3-methylpiperazin-1-yl)pyridazin-3-amine (370 mg, 1.62 mmol) (prepared as in example G02939250) was dissolved in dimethylformamide (8 mL) for the addition of tert-butyl 2-bromopropanoate (0.44 g, 2.11 mmol), followed by potassium carbonate (0.45 g, 3.24 mrnol). The solution was heated to 60 C for 72 h. The reaction mixture waspartitioned between ethyl acetate and sodium bicarbonate (aq., sat.). The organic layer was washed with brine, dried with sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified by silica gel chromatography (eluting with hexanes and ethyl acetate) to afford the title compound (0.42 g, 1.19 mmol, 73%). LCMS I41Z (M+H) 356.

The chemical industry reduces the impact on the environment during synthesis tert-Butyl 2-bromopropanoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; CRAWFORD, Terry; DUPLESSIS, Martin; GOOD, Andrew, Charles; LEBLANC, Yves; MAGNUSON, Steven, R.; NASVESCHUK, Christopher, G.; ROMERO, F. Anthony; TANG, Yong; TAYLOR, Alexander, M.; (271 pag.)WO2016/138114; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39149-80-9, name is tert-Butyl 2-bromopropanoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: tert-Butyl 2-bromopropanoate

General procedure: A solution of NaHMDS (1.0 M in THF, 2.1 mL, 2.1 mmol) was added dropwise to the solution of 15 (R4 and R5 are methyl, 334 mg, 2.0 mmol) in THF (10 mL) at 78 C under argon. After 5 min, a solution of 16 (152 mg, 1.0 mmol) in THF (5 mL) was added dropwise. After another 5 min, the reaction was quenched with saturated ammonium chloride solution. The aqueous phase was extracted with EtOAc (3 20 mL). The combined organic layer was washed with saturated brine and dried over Na2SO4. The solvent was removed under reduced pressure

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 39149-80-9.

Reference:
Article; Li, Qing; Xiao, Fenfen; Wang, Yunxia; Hu, Xiangdong; Synthetic Communications; vol. 46; 12; (2016); p. 1062 – 1067;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 39149-80-9, name is tert-Butyl 2-bromopropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39149-80-9, Computed Properties of C7H13BrO2

(1) Preparation of 2-(quinolin-5-yloxy)propanoic acid (A01): Quinolin-5-ol (0.868 g, 5.98 mmol) and tert-butyl 2-bromopropanoate (1.25 g, 0.97 mL, 5.98 mmol) and cesium carbonate (1.95 g, 5.98 mmol) were added into DMF (10 mL) in a 20 mL microwave vial equipped with a stir bar and sealed. The mixture was heated in Biotage microwave synthesizer for 1 hour at 100 C. The solvent was removed and the remained sticky oil was dissolved in DCM (7 mL) and TFA (7 mL). The mixture was stirred overnight. The reaction mixture was neutralized with sodium bicarbonate and organic layer was separated from the mixture. The aqueous layer washed with DCM (2*10 mL), combined organics and acidified with 2N HCl. Aqueous was extracted with ethyl acetate, dried with sodium sulfate and concentrated to a dark orange oil. The crude product was dissolved in DCM (4 mL) and a pure product (0.855 g) precipitate out from the solution by adding diethyl ether (4 mL).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 2-bromopropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bristol-Myers Squibb Company; US2007/287730; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39149-80-9, name is tert-Butyl 2-bromopropanoate, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H13BrO2

A.i. (RS)-tert-Butyl 2-(methylsulfonyl)propanoate : To a suspension of sodium methanesulfinate (100 g; 929 mmol) in tBuOH (350 mL) was added iert-butyl-2-bromopropionate (150 mL; 877 mmol). The reaction mixture was stirred at 90C for 24 h under nitrogen atmosphere, then cooled to rt and concentrated to dryness. The residue was partitioned between water (750 mL) and EA (600 mL). The aq. layer was extracted with EA (2 x 500 mL). The evaporation residue afforded the title compound as a white yellow solid (175 g; 96% yield). 1H NMR (DMSO-d6) delta: 4.24 (q, J = 7.2 Hz, 1H); 3.1 1 (s, 3H); 1.45 (s, 9H); 1.40 (d, J = 7.2 Hz, 3H).

According to the analysis of related databases, 39149-80-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; DIETHELM, Stefan; GAUVIN, Jean-Christophe; JACOB, Loic; PANCHAUD, Philippe; SCHMITT, Christine; SURIVET, Jean-Philippe; TIDTEN-LUKSCH, Naomi; (79 pag.)WO2019/86452; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 39149-80-9, name is tert-Butyl 2-bromopropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39149-80-9, Product Details of 39149-80-9

Sodium hydride (60% dispersion in mineral oil) (1.02 g, 25.43 mmol) was added to a solution of methyl 2-(2-bromo-4-fluorophenyl)acetate (5.24 g, 21.19 mmol) and 1,3- dimethyl-3,4,5,6-tetrahyaYo-2(lH)-pyrimidinone (2.56 mL, 21.19 mmol) in anhydrous THF (50 mL). The reaction mixture was stirred for 15 min. before a solution of tert-butyl- 2-bromopropionate (5.32 g, 25.43 mmol) in anhydrous THF (5 mL) was added to it. The reaction mixture was stirred at room temperature overnight. The reaction mixture was heated to 60C for a further 24 h. After that time, the mixture was cooled to room temperature and poured onto water. The mixture was extracted with EtOAc and the combined organic layers were washed with brine, dried (Na2S04), filtered and concentrated in vacuo. The crude material was purified by column chromatography on silica, eluted with 10% EtOAc/hexane to afford the title compound. (0689) ?H NMR (400 MHz, CDCb) 8ppm 0.87 – 1.01 (m, 2 H), 1.19 (s, 4 H), 1.23 – 1.29 (m, 1 H), 1.46 (s, 5 H), 2.92 – 3.23 (m, 1 H), 3.55 – 3.72 (m, 3 H), 4.29 – 4.46 (m, 1 H), 6.94 – 7.07 (m, 1 H), 7.26 – 7.49 (m, 2 H)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, tert-Butyl 2-bromopropanoate, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; LIWICKI, Gemma; MACK, Stephen; STEPHENSON, Anne; TEALL, Martin; WHITE, Kathryn; (168 pag.)WO2018/47983; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics