Application of 37555-99-0, These common heterocyclic compound, 37555-99-0, name is Diethyl 2-ethoxymalonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Part A Preparation of mono-ethyl ethoxymalonate Diethyl ethoxymalonate (10.08 grams, 0.05 mole), prepared as described in Example LXVII, Part B, was saponified with potassium hydroxide (2.77 grams, 0.05 mole) in a mixture of 200 milliliters of ethanol and 0.88 gram (0.05 mole) of water and worked up under conditions similar to those described in Example LIX giving 4.32 grams (0.02 mole) of mono-ethyl ethoxymalonate as a residue product. NMR analysis of the product indicated the following: ‘H NMR(CDCl3) delta1.13-1.49(2xt, 6H, 2*CH3), 3.51-3.95(q, 2H, ether CH2 O), 4.10-4.50(q, 2H, ester CH2 O), 4.53(s, methine CH), 6.95(s, COOH) ppm.
The synthetic route of 37555-99-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Rhone-Poulenc Nederland B.V.; US5123951; (1992); A;,
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