Category: 37466-90-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37466-90-3, name is Ethyl 3,4-diaminobenzoate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Ethyl 3,4-diaminobenzoate

General procedure: A mixture of o-phenylenediamine (1.0 mmol), aryl aldehyde(1.0 mmol) and chromium(III) salen complex nanoparticles supported on AlPO4(2.0 mol%) in ethanol (5 mL) was stirred at room temperature. After completion of the reaction (TLC), the mixture was centrifuged and rinsed with ethanol (3 ¡Á 15 mL). The recovered nanocatalyst was dried and stored for another consecutive runs. The solvent was evaporated to give the crude product, which was purified by silica gel column chromatography employing n-hexane/ethyl acetate (8:1) as eluent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 37466-90-3.

Reference:
Article; Sharghi, Hashem; Aberi, Mahdi; Doroodmand, Mohammad Mahdi; Shiri, Pezhman; Journal of the Iranian Chemical Society; vol. 14; 7; (2017); p. 1557 – 1573;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

37466-90-3, name is Ethyl 3,4-diaminobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Ethyl 3,4-diaminobenzoate

General procedure: The corresponding dianiline (1 eq.), the corresponding aromatic acid (1.1 eq.), HATU (1.1 eq.) and N,N-diisopropyl-ethylamine (2 eq.) in dichloromethane (2 mL/g) was stirred overnight at room temperature. The product was isolated as per specification.

The synthetic route of 37466-90-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Elkins, Jonathan M.; Fala, Angela M.; Massirer, Katlin B.; Pennicott, Lewis E.; Reuillon, Tristan D.; Scott, Fiona; Ward, Simon E.; Bioorganic and medicinal chemistry letters; (2020);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37466-90-3, name is Ethyl 3,4-diaminobenzoate, A new synthetic method of this compound is introduced below., SDS of cas: 37466-90-3

General procedure: A flask was charged with o-phenylenediamine (1a; 54 mg, 0.5 mmol), hexafluoroacetylacetone (2; 125 mg, 0.6 mmol), Fe(OTf)3 (25 mg, 0.05 mmol), DMF (2.0 mL). The reaction was stirred at 80 C for 24 h, when the reaction was complete monitored by TLC, the mixture was cooled to room temperature. Water (10 mL) was added to the mixure, and then extracted with EtOAc (3¡Á30 mL). The combined organic phase was washed with water, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the product 3a (92 mg, 99%) as yellow solid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Zhou, Yanmei; Shen, Guanshuo; Sui, Yuebo; Zhou, Haifeng; Tetrahedron Letters; vol. 57; 30; (2016); p. 3396 – 3399;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

37466-90-3, Name is Ethyl 3,4-diaminobenzoate, 37466-90-3, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

General procedure: Ethyl-3-amino-4-(2-substituted amino)benzoate, 3 (1 mmol) and various sodium bisulfite adducts, 4 (1.5 mmol) were dissolved in DMF (5 mL). The reaction mixture was stirred at 90 C under N2 atmosphere for 24-48 h. After completion of reaction (evident by TLC), the reaction mixture was diluted in ethyl acetate (25 mL) and washed with water (10 mL¡Á3). The organic layer was collected, dried over Na2SO4 and evaporated under reduced pressure to afford crude products. Final compounds 5-7 were obtained in 38-90% yields after recrystallization from ethanol or column purification.

Statistics shows that Ethyl 3,4-diaminobenzoate is playing an increasingly important role. we look forward to future research findings about 37466-90-3.

Reference:
Article; Yoon, Yeong Keng; Ali, Mohamed Ashraf; Wei, Ang Chee; Choon, Tan Soo; Ismail, Rusli; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 614 – 624;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37466-90-3, name is Ethyl 3,4-diaminobenzoate, This compound has unique chemical properties. The synthetic route is as follows., 37466-90-3

General procedure: Ethyl-3-amino-4-(2-substituted amino)benzoate, 3 (1 mmol) and various sodium bisulfite adducts, 4 (1.5 mmol) were dissolved in DMF (5 mL). The reaction mixture was stirred at 90 C under N2 atmosphere for 24-48 h. After completion of reaction (evident by TLC), the reaction mixture was diluted in ethyl acetate (25 mL) and washed with water (10 mL¡Á3). The organic layer was collected, dried over Na2SO4 and evaporated under reduced pressure to afford crude products. Final compounds 5-7 were obtained in 38-90% yields after recrystallization from ethanol or column purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Yoon, Yeong Keng; Ali, Mohamed Ashraf; Wei, Ang Chee; Choon, Tan Soo; Ismail, Rusli; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 614 – 624;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

37466-90-3, These common heterocyclic compound, 37466-90-3, name is Ethyl 3,4-diaminobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthesis of 2-Oxo-2,3-dihydro-lH-benzoimidazole-5-carboxylic acid ethyl ester ’22a): 3,4-Diamino-benzoic acid ethyl ester (100 mg, 0.56 mmol) was dissolved in 5 mL of IHF and cooled to 00C. Triethyamine (77 muL, 0.56 mmol) was added followed by potassium carbonate (230 mg, 1.68 mmol). Triphosgene (82 mg, 0.28 mmol) was added in one portion, md the reaction mixture was then warmed up to room temperature and quenched with saturated ammonium chloride solution. The mixture was extracted with ethyl acetate. The organic layers were combined, washed with brine and dried over MgSO4. Solvent was then removed and the residue was purified by column chromatography (60% ethyl acetate/hexanes). The product (92 mg, 80%) was obtained as a white solid. MS (ES) M+H expected = 207.1, found = 207.1.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 37466-90-3.

Reference:
Patent; CHEMOCENTRYX, INC.; WO2007/51062; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

37466-90-3, name is Ethyl 3,4-diaminobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 37466-90-3

Step 6-1-1 Ethyl 2,3-dimethylquinoxaline-6-carboxylate Ethyl 3,4-diaminobenzoate (500 mg, 2.77 mmol) and diacetyl (238 mg, 2.77 mmol) were dissolved in ethanol (20 ml), and the mixture was heated under reflux. One hour after, diacetyl (30 mg) was added thereto, and the mixture was heated under reflux. After the mixture was heated under reflux for 2.5 hours in total, the reaction solution was poured into water, and the precipitate was separated by filtration and washed with water. By through circulation drying for 15 hours, the title compound (650 mg, quantitative) as a light-brown powder was obtained. 1H-NMR (DMSO-d6) delta: 8.52 (d, J=1.5 Hz, 1H), 8.19 (dd, J=1.9, 8.5 Hz, 1H), 8.07 (d, J=8.5 Hz, 1H), 4.40 (q, J=6.9 Hz, 2H), 2.72 (s, 3H), 2.72 (s, 3H) Mass, m/z: 230 (M+), 185 (base)

Statistics shows that 37466-90-3 is playing an increasingly important role. we look forward to future research findings about Ethyl 3,4-diaminobenzoate.

Reference:
Patent; Uchida, Hiroshi; Asagarasu, Akira; Matsui, Teruaki; US2013/79306; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37466-90-3 name is Ethyl 3,4-diaminobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 37466-90-3

General procedure: Compound 3 (10 mmol) was dissolved in ethylene glycol (50 mL) andthen compound 2 (10 mmol) and a small amount of polyphosphoricacid were added to the stirred solution which was then refluxed forseveral hours (the reaction was monitored by TLC). On completion ofthe reaction, the mixture was poured into ice water. The solution wastreated with 30% sodium hydroxide to slight alkalinity (pH = 9). Theprecipitated solid was filtered off, recrystallised from ethanol anddried in vacuo to give compound 4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 3,4-diaminobenzoate, and friends who are interested can also refer to it.

Reference:
Article; Wang, Xinying; Liu, Yizhou; Xu, Juan; Jiang, Fanwei; Kang, Congmin; Journal of Chemical Research; vol. 40; 10; (2016); p. 588 – 590;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics