Category: 369-26-6

Reference of 369-26-6,Some common heterocyclic compound, 369-26-6, name is Methyl 3-amino-4-fluorobenzoate, molecular formula is C8H8FNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Methyl 3-amino-4-fluorobenzoate (275mg) and DMAP (100mg) were dissolved in pyridine (lOml). Then cyclopropanesulfonyl chloride (330mg) was added into the solution. The reaction mixture was heated to 110¡ãC and stirred for 12 hours until the reaction is complete. The solvent was stripped off, the solid was dissolved in CH2C12 (50m1) followed by iN HC1 solution (50m1). The bottom aqueous layer was split off and the organic layer was washed with water and dried by anhydrous Na2SO4. The CH2C12 was stripped off and 270mg of methyl 3 -(cyclopropanesulfonamido)-4-fluorobenzoate was used for the next step directly.

The synthetic route of 369-26-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHILADELPHIA HEALTH & EDUCATION CORPORATION, D/B/A DREXEL; INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH; ENANTIGEN THERAPEUTICS, INC.; BAUGH, Simon David Peter; YE, Hong; XU, Xiaodong; GUO, Ju-tao; XIAO, Tong; DU, Yanming; BLOCK, Timothy; WO2014/106019; (2014); A2;,
Ester – Wikipedia,
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Adding some certain compound to certain chemical reactions, such as: 369-26-6, name is Methyl 3-amino-4-fluorobenzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 369-26-6. 369-26-6

Step 2: Preparation of methyl 4-fluoro-3-(methylsulfonamido)benzoate (55) A solution of methyl 3-amino-4-fluorobenzoate (0.970 g, 5.73 mmol) in dry pyridine (12 ml), was cooled to 0¡ã C. and methanesulfonyl chloride (0.577 ml, 7.45 mmol) was added drop wise. The resulting mixture was allowed to warm to room temperature and stirred for 3 hours. The solvent was evaporated and the residue was partitioned between DCM and aq. NaHCO3 sat. sol. The organic layer was washed with brine and dried over Na2SO4; the solvent was evaporated and the residue was purified by flash chromatography on silica gel column (ethyl acetate:petroleum ether: 35:65) affording methyl 4-fluoro-3-(methylsulfonamido)benzoate as an off white powder (0.400 g, 1.618 mmol, 28.2percent yield, MS/ESI+ 248.1 [MH]+).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Methyl 3-amino-4-fluorobenzoate.

Reference:
Patent; CHIESI FARMACEUTICI S.p.A.; ARMANI, Elisabetta; Amari, Gabriele; Esposito, Oriana; Carzaniga, Laura; Capaldi, Carmelida; US2014/155391; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

369-26-6, Adding some certain compound to certain chemical reactions, such as: 369-26-6, name is Methyl 3-amino-4-fluorobenzoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 369-26-6.

To a solution of methyl 3-amino-4-fluorobenzoate (100 mg, 0.591 mmol) in DCM (3 ml) was added 4-(l-methylethyl)benzoyl chloride (162 mg, 0.887 mmol) and pyridine (96 mu, 1.18 mmol) at room temperature. The mixture was stirred for 1 h. 1 M HC1 and DCM were added and the phases were separated, the organic phase collected and the volatiles were removed in vacuo. The compound was purified by flash column chromatography. Yield: 135 mg (72percent); white solid. MS (ESI+) m/z 316 [M+H]+. HPLC purity: 99percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 369-26-6.

Reference:
Patent; KANCERA AB; HAMMER, Kristin; JOeNSSON, Mattias; KRUeGER, Lars; (230 pag.)WO2017/108282; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

369-26-6, name is Methyl 3-amino-4-fluorobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 369-26-6

Step 1 : 3-Amino-N-(2-tert-butoxyethyl)-4-fluorobenzamide A mixture comprising 2-tert-butoxyethanamine (1 .2 g, 5.12 mmol, 50percentw/w) and methyl 3-amino-4-fluorobenzoate (0.866 g, 5.12 mmol) in THF (10 ml) was treated with TBD (0.713 g, 5.12 mmol) and heated at 90 ¡ãC for 16 hrs. After cooling to RT, the solvent was removed in vacuo and the residue was partitioned between water and EtOAc. The organic portion was separated and washed with 10percent aq citric acid (x 2), NaHC03(sat. aq), brine, dried (MgS04) and concentrated in vacuo. Purification of the crude product by chromatography on silica eluting with 0-100percent EtOAc in iso- hexane afforded the title compound as a clear oil;LC-MS: Rt 1.09 mins; MS m/z 255 [M+H]+; Method 2minl_C_v003

Statistics shows that 369-26-6 is playing an increasingly important role. we look forward to future research findings about Methyl 3-amino-4-fluorobenzoate.

Reference:
Patent; NOVARTIS AG; IRM LLC; BRUCE, Ian; CHAMOIN, Sylvie; COLLINGWOOD, Stephen Paul; FURET, Pascal; FURMINGER, Vikki; LEWIS, Sarah; LOREN, Jon Christopher; MOLTENI, Valentina; SAUNDERS, Alex Michael; SHAW, Duncan; SVIRIDENKO, Lilya; THOMSON, Christopher; YEH, Vince; JANUS, Diana; WEST, Ryan; WO2013/30802; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 369-26-6, name is Methyl 3-amino-4-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 369-26-6

To a suspension of compound 21 (1.01 g, 6 mmol) in hydrochloric acid (13 ml, 37%) at 0 C was added a cold solution of sodium nitrite (0.50 g, 7.2 mmol) in water (5 ml) maintaining the temperature below 5 C. The resultant solution was stirred in an ice bath for 30 min before the addition of a solution of tin(II) chloride dihydrate (4.06 g, 18 mmol) in hydrochloric acid (5 ml, 37%) maintaining the temperature below 5 C. The resultant suspension was stirred at 0 C for 3 h and the suspension filtered and then dissolved in DCM, washed with saturated NaHCO3, dried over by MgSO4 to get the compound 22 (1.01 g, 92%). 1H NMR (CDCl3, 400 MHz): delta 7.79-7.77 (m, 1H), 7.46 (s, 1H), 7.04-6.99 (m, 1H), 5.48 (br, 1H), 3.91 (s, 3H) 3.62 (br, 2H). ESI-HRMS: m/z calcd for C8H9FN2O2 [M+H]+ 185.0682 found 185.0664.

The synthetic route of 369-26-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lu, Chaocao; Htan, Bu; Fu, Shitao; Ma, Chunmiao; Gan, Quan; Tetrahedron; vol. 75; 30; (2019); p. 4010 – 4016;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics