Costales, Paula; Rios-Lombardia, Nicolas; Lorenzo-Herrero, Seila; Moris, Francisco; Gonzalez-Sabin, Javier published the artcile< Novel chiral naphthalimide-cycloalkanediamine conjugates: Design, synthesis and antitumor activity>, Category: esters-buliding-blocks, the main research area is naphthalimide cycloalkanediamine conjugate diastereoselective preparation DNA photocleavage antitumor SAR; apoptosis naphthalimide cycloalkanediamine conjugate diastereoselective preparation; Apoptosis; Cycloalkanediamine; Cytotoxicity; Naphthalimide; Structure-activity relationship.
A novel series of enantiopure naphthalimide-cycloalkanediamine conjugates I [n = 1,2], II [R = H, NO2; X = 2,4], III, IV were designed, synthesized starting from 1,8-naphthalic anhydride and evaluated for in vitro cytotoxicity against human colon adenocarcinoma (LoVo), human lung adenocarcinoma (A549), human cervical carcinoma (Hela) and human promyelocytic leukemia cell lines (HL-60). The cytotoxicity of the compounds I, II, III and IV was highly dependent on size and relative stereochem. of the cycloalkyl ring as well as length of the spacer. By contrast, any kind of enantioselection was observed for each pair of enantiomers. Flow cytometric anal. indicated that compounds II [R = NO2; n = 2] could effectively induced G2/M arrest in the four previous cell lines despite a mild apoptotic effect.
Bioorganic Chemistry published new progress about Antitumor agents. 364385-54-6 belongs to class esters-buliding-blocks, and the molecular formula is C11H22N2O2, Category: esters-buliding-blocks.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics