35615-97-5, name is Methyl 4-bromonaphthalene-1-carboxylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 35615-97-5
A stirred solution of methyl 4-bromo-I-naphthoate (Collect. Czech. Chem. Commun. 1997, 62(11), 1737; 7.3g, 28mmole) in degassed toluene (300ml) was treated with hexamethylditin (10g, 31mmole) and tetrakis(triphenylphosphine)palladium(0) (720mg) and heated at reflux under argon for 3h.. On cooling, the mixture was filtered through Celite (Diatomaceous Earth), concentrated under vacuum and the residue chromatographed on silica gel eluding with 0-3% ether/60-80 petrol to afford the title compound as a colourless oil (9.06g, 94%)
The synthetic route of 35615-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SmithKline Beecham plc; EP1216239; (2004); B1;,
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