3549-23-3, name is Methyl 2-(4-(tert-butyl)phenyl)acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Methyl 2-(4-(tert-butyl)phenyl)acetate
The appropriate aryl-ester 18a-e (1 eq), was added of EtOH (2.22 ml*mmol/eq) followed by hydrazine monohydrate (3 eq). The solution was refluxed overnight, then cooled to room temperature. The precipitate obtained was filtered and washed with cold EtOH and n-hexane to give the pure product. Synthesised as described above for hydrazides 19a-e. Obtained as a yellow oil in 88percent yield as a white solid.1H-NMR (DMSO-d6), delta: 1.26 (s, 9H), 3.30 (s, 2H), 4.13 (bs, 2H), 7.18 (d, J = 8.2 Hz, 2H), 7.30 (d, J = 8.2 Hz, 2H), 9.18 (bs, 1H). 13C-NMR (DMSO-d6): delta: 31.1, 39.9, 34.1, 124.7, 124.8, 133.2, 148.6, 169.6.
The synthetic route of 3549-23-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Giancotti, Gilda; Cancellieri, Michela; Balboni, Andrea; Giustiniano, Mariateresa; Novellino, Ettore; Delang, Leen; Neyts, Johan; Leyssen, Pieter; Brancale, Andrea; Bassetto, Marcella; European Journal of Medicinal Chemistry; vol. 149; (2018); p. 56 – 68;,
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