Category: 35450-36-3

Adding a certain compound to certain chemical reactions, such as: 35450-36-3, name is Methyl 2-bromo-5-methoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35450-36-3, Recommanded Product: 35450-36-3

Intermediate 11 :Methyl 2-bromo-5-methoxy benzoate (20.0 g, 81.61 mmol), tri methyl bo roxine (13.36 ml_, 97.93 mmol), Pd(dppf)CI2 (1.0 g, 1.36 mmol), dioxane (350 ml_), water (50 ml_), and Cs2CO3 (22.5 g, 163 mmol) were stirred at 11OC (oil bath) under nitrogen for 16 hours. After cooling, the solid was removed by filtration. The solution was concentrated and purified by SGC (10:1 EtOAc/hexanes) to give 11 (12.1 g, 80%). Mass calculated for formula C10H12NO3 , 180.20, observed LCMS m/z 181.20 (M+H).NMR (H1); 2.35(3H,CH3) 3.73(3H, – OCH3),3.88(3 H, CO2-CH3),6.86-7.5(m,3H,Aromatic)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; SCHERING CORPORATION; WO2009/14637; (2009); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 35450-36-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35450-36-3, name is Methyl 2-bromo-5-methoxybenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

a) 2-[(E)-2-(3-Chlorophenyl)vinyl]-5-methoxybenzoic acid methyl ester To a stirred solution of 2-bromo-5-methoxybenzoic acid methyl ester (17.7 g, 72.2 mmol) and 3-chlorovinylbenzene (9.17 mL, 72.2 mmol) in anhydrous acetonitrile (180 mL) was added triethylamine (20.10 mL, 144 mmol) and tris(o-tolyl)phosphine (2.85 g, 9.38 mmol). The reaction mixture was sparged with argon for 5 min, palladium(II) acetate (1.62 g, 7.22 mmol) was added and the mixture heated at 85 C. under an argon atmosphere for 21 h. The product mixture was filtered through celite, concentrated in vacuo, the residue dissolved in ethyl acetate (400 mL) and washed with 1 N HCl (aq.) (200 mL) and brine (200 mL). The combined aqueous layers were back-extracted with ethyl acetate (200 mL). The ethyl acetate extracts were combined, dried (MgSO4) and concentrated under reduced pressure to give the crude 2-[(E)-2-(3-chlorophenyl)vinyl]-5-methoxybenzoic acid methyl ester as a red-brown, viscous oil which was used in the next step without further purification. Data for 2-[(E)-2-(3-chlorophenyl)vinyl]-5-methoxybenzoic acid methyl ester: 1H NMR (300 MHz, CDCl3): delta 7.91 (d, 1H), 7.63 (d, 1H), 7.49 (dd, 1H), 7.44 (d, 1H), 7.41 (ddd, 1H), 7.26 (d, 1H), 7.21 (ddd, 1H), 7.08 (dd, 1H), 6.83 (d, 1H), 3.94 (s, 3H), 3.86 (s, 3H) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromo-5-methoxybenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; N.V. Organon; US2008/64678; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics