Sources of common compounds: C5H7F3O2

Adding a certain compound to certain chemical reactions, such as: 352-23-8, name is Ethyl 3,3,3-trifluoropropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 352-23-8, Recommanded Product: Ethyl 3,3,3-trifluoropropanoate

Adding a certain compound to certain chemical reactions, such as: 352-23-8, name is Ethyl 3,3,3-trifluoropropanoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 352-23-8, Recommanded Product: Ethyl 3,3,3-trifluoropropanoate

To a stirred mixture solution of ethyl 3,3,3-trifluoropropanoate (10.0 g, 64.1 mmol) and Et3N (7.8 g, 76.9 mmol) in CHCl3 (100.0 mL) was added TMSOTf (17.4 g, 76.9 mmol) dropwise in an ice-water batch. After the addition, TiCl< SUB>4< /SUB> (9.61 mL, 1.0 M in DCM) was added. The resulting reaction mixture was allowed to warmed up to room temperature and stirred at 25< SUP>o< /SUP>C for 1 h. The reaction was re-cooled in an ice bath before it was quenched with water (100 mL). The organic layer was separated, dried over anhy. MgSO< SUB>4< /SUB>, filtered, and concentrated in vacuo to give a crude product of ethyl 3,3-difluoroacrylate as oil, which was used directly in the next step without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3,3,3-trifluoropropanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DEY, Fabian; HU, Yimin; LIU, Yongqiang; LIN, Xianfeng; SHEN, Hong; SHI, Houguang; TAN, Xuefei; VERCRUYSSE, Maarten; YAN, Shixiang; ZHOU, Chengang; ZHOU, Mingwei; (443 pag.)WO2018/178041; (2018); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics