Category: 35065-86-2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 35065-86-2, name is 3-Bromophenyl acetate, A new synthetic method of this compound is introduced below., Formula: C8H7BrO2

3-Bromophenol (5) (10.0 g, 58 mmol) was dissolved in pyridine(30 mL) under ice-bath and was stirred for 30 min. Acetic anhydride (8.3 mL, 88 mmol) was added dropwise into above mixture at the same temperature. The ice-bath was removed after dropping and the mixture was stirred for 2 h. Concentrated HCl and ice-water (300 mL) was added to neutralize pH to 7. The mixture was extracted with AcOEt (100 mL 3). The organic layer was collected and washed with brine and dried over Na2SO4. Filtration and concentration in vacuo afforded yellow oil. In a 250 mL round bottom flask, the obtained yellow oil (6.45 g, 30 mmol) and anhydrous AlCl3 (12.02 g, 90 mmol) was mixed at 160 C for three hours. Reaction mixture was poured into ice water and concentrated hydrochloric acid solution was added to break complex formed during reaction.The mixture was taken in AcOEt (50 mL 3). The organic layer was combined and washed with water and brine, and dried over Na2SO4. After filtration and concentration in vacuo, the residues was purified by silica gel flash chromatography (PE/AcOEt 30:1) give (6) (4.74 g, 73.5%) as white solid.

The synthetic route of 35065-86-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gao, Hongping; Su, Ping; Shi, Yaling; Shen, Xiuxiu; Zhang, Yanmin; Dong, Jinyun; Zhang, Jie; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 232 – 240;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 35065-86-2, name is 3-Bromophenyl acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35065-86-2, Safety of 3-Bromophenyl acetate

In a 250 mL round bottom flask (8) (5.49 g, 26 mmol) and anhydrous AlCl3 (6.92 g, 51 mmol) was mixed thoroughly on oil bath at 160 C for 2 h. Reaction mixture was poured into ice water and concentrated hydrochloric acid solution was added to break complex formed during reaction. The mixture was taken in AcOEt (50 mL * 3). The organic layer was combined and washed with water and brine, and dried over Na2SO4. After filtration and concentration in vacuo, the residues was purified by silica gel flash chromatography (PE/AcOEt = 30:1) gave (9) (3.85 g, 70 %) as white solid. Mp: 36-38 C, MS (EI) [M]+: m/z = 213, 1H NMR (400 MHz, CDCl3) delta ppm: 7.60 (d, J = 8.0 Hz, 1H), 7.20 (s, 1H), 7.07 (d, J = 8.0 Hz, 1H), 2.63 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromophenyl acetate, and friends who are interested can also refer to it.

Reference:
Article; Wang, Chen; Gao, Hongping; Dong, Jinyun; Zhang, Yanmin; Su, Ping; Shi, Yaling; Zhang, Jie; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 277 – 284;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 35065-86-2, name is 3-Bromophenyl acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35065-86-2, Recommanded Product: 3-Bromophenyl acetate

Acetylated intermediate and aluminum trichloride (2.3g) with vigorous stirringThe mixture was heated to 160 C under an argon atmosphere for 2 h in a 50 mL single-mouth bottle, cooled to room temperature, and extracted with a 3 M hydrochloric acid solution and ethyl acetate.After the organic phase is washed with water and a saturated sodium chloride solution,Dry over anhydrous sodium sulfate.After concentration, column chromatography gave 1 g of pale yellow solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenyl acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Changsen Pharmaceutical Co., Ltd.; Wang Zhe; Fan Guoqin; Zeng Zhihong; Wang Xiaoguang; Jiang Rongzhen; (64 pag.)CN109678796; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 35065-86-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35065-86-2, name is 3-Bromophenyl acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A stirred solution of the appropriate bromophenyl alkanoic acid(1 eq) in MeOH (25 mL)was treated with H2SO4 (0.1 eq of a conc. aq.solution) and heated at reflux for 18 h. The resultant solution wascooled to room temperature and concentrated under reducedpressure. The resultant oil was diluted with NaHCO3 (50 mL of a sat.aq. solution) and subsequently extracted with diethyl ether(3 25 mL). The combined organics were washed with brine(1 100 mL), dried (MgSO4), filtered and concentrated underreduced pressure to give the desired methyl ester:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenyl acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jorgensen, William T.; Gulliver, Damien W.; Katte, Timothy A.; Werry, Eryn L.; Reekie, Tristan A.; Connor, Mark; Kassiou, Michael; European Journal of Medicinal Chemistry; vol. 143; (2018); p. 1644 – 1656;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics