Introduction of a new synthetic route about Di-tert-butyl 2-methylmalonate

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34812-95-8, name is Di-tert-butyl 2-methylmalonate, A new synthetic method of this compound is introduced below., HPLC of Formula: C12H22O4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34812-95-8, name is Di-tert-butyl 2-methylmalonate, A new synthetic method of this compound is introduced below., HPLC of Formula: C12H22O4

[00129] To a salted ice (-10 – 0C) cooled solution of UB-12527 (20.0g, 86.8mmol, 1.0 equiv., in 190ml of dry tetrahydrofuran) 3.47g (86.8mmol, l.Oequiv., 60% in mineral oil) of sodium hydride was added. The mixture was warmed to room temperature then stirred for 30min. To the resulting white suspension 15.5ml (130mmol, 1.5equiv.) of 1,4- dibromobutane was added and the mixture was stirred overnight. The mixture was evaporated and the residue was dissolved in 250ml of water and 250ml of MTBE. The phases were separated, the organic was dried over sodium sulfate and evaporated. The crude product was purified by rectification (0.7-0.8mbar, 111-125C). Yield: 14.4g (39.5mmol, 45.5%) colourless, clear oil. GC: 96.7%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; APOSENSE LTD.; VAN GELDER, Joel M.; LEVY, Menashe; ARGOV, Mirit; BEN-AMI, Miri; ZIV, Ilan; WO2013/150534; (2013); A1;,
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