Category: 3469-00-9

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3469-00-9, name is Methyl Diphenylacetate, This compound has unique chemical properties. The synthetic route is as follows., name: Methyl Diphenylacetate

(2) Preparation of 2,2-diphenylethanol To a 500mL three-opening flask was slowly added a solution of diisobutylaluminum hydride in toluene (282mL, 1mol/L) at -30C. After stirring, to the resulting mixture was slowly added a solution of methyl 2,2-diphenylacetate (21g, 92.8mmol) in dichloromethane dropwisely. After the completion of dropwise addition, the reaction was conducted at 25 C for 12 hours. After the completion of reaction monitored by TLC, to the resulting mixture was slowly added methanol (10mL), dichloromethane (100mL) and an aqueous sodium hydroxide solution (100mL, 1mol/L) at -20C. After the completion of reaction, to the reaction solution was added dichloromethane for extraction. The organic phase was washed with water, dried over anhydrous sodium sulfate, and evaporated to remove the solvent to produce 2,2-diphenyl ethanol (17 g) in a yield of 92.4 %.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3469-00-9.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; ZHANG, Hui; FAN, Mingwei; SUN, Liang; EP2703398; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 3469-00-9,Some common heterocyclic compound, 3469-00-9, name is Methyl Diphenylacetate, molecular formula is C15H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2,2-Diphenylacetohydrazide To a stirred solution of methyl 2,2-diphenylacetate (0.5 g, 1 equiv) in anhydrous EtOH (150 mL) was added hydrazine hydrate (8 mL) and heated to reflux. Stirring was then continued for 1 hour. The reaction mixture was then cooled and the solvents removed under reduced pressure. The crude oil was diluted with EtOAc and washed with H2O and the organic phase dried over Na2SO4, filtered, and the solvents removed under reduced pressure to yield a yellow oil (0.97 g, 97%) that was used without further purification.

The synthetic route of 3469-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Omeros Corporation; US2010/35872; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 3469-00-9,Some common heterocyclic compound, 3469-00-9, name is Methyl Diphenylacetate, molecular formula is C15H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 2.5 M solution of n-BuLi in hexane (2.04 mL, 5.10 mmol, 1.02 equiv) is added dropwise to a solution of diisopropylamine (0.74 mL, 5.25 mmol,1.05 equiv) in anhydrous THF (5 mL) at -78 C under Ar atmosphere and thereaction mixture is allowed to stir for 30 min at -78 C. After stirring an additional 30 min at -5 C, a solution of methyl 2,2-diphenylacetate (1.13 g, 5.00 mmol,1.00 equiv) in anhydrous THF (2 mL) is added dropwise at -78 C, and the reaction mixture is allowed to stir for 10 min. Finally, crotyl bromide (trans, 85% pure; 810 mg,6.00 mmol, 1.20 equiv) is added dropwise at -78 C and the mixture is slowly warmed to rt. After stirring for 16 h at rt, the reaction mixture is cooled to 0 C, quenched by the addition of saturated aq. NH4Cl (10 mL) then extracted with Et2O (4 × 10 mL). The combined organic extracts are washed with brine, dried overanhydrous Na2SO4, filtered and concentrated under reduced pressure; yield: 1.00 g, 3.57 mmol, 71%, yellow liquid. The product is obtained as inseparable mixture of E/Z isomers (90:10; cf. NMR spectra).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl Diphenylacetate, its application will become more common.

Reference:
Article; Rode, Katharina; Palomba, Martina; Ortgies, Stefan; Rieger, Rene; Breder, Alexander; Synthesis; vol. 50; 19; (2018); p. 3875 – 3885;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3469-00-9, name is Methyl Diphenylacetate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

Step 1 : Methyl 2.2-bis(4-nitrophenyl)acetate (8). Compound 7 (6 g, 26.5 mmol) was dissolved in fuming nitric acid (60 mL) and stirred at room temperature for 16 h. The reaction mixture was poured onto ice, the resulting light yellow sludge was separated out then dissolved in ether to provide a solid. Filtration afforded title compound 8 as a white solid (1.15 g, 14%). 1H NMR (DMSO-d6) delta (ppm):8.22 (d, J = 9.0 Hz, 4H), 7.65 (d, J = 8.6 Hz, 4H), 5.76 (s, IH), 3.72 (s, 3H).

The synthetic route of 3469-00-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; METHYLGENE INC.; WO2008/122115; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 3469-00-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3469-00-9, name is Methyl Diphenylacetate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 4.2 General procedures: A. Microwave. Neat samples of amine (1.00 mmol) and carboxylic derivative (methyl ester or acid, 1.00 mmol) and DABAL-Me3 (202 mg, 0.8 equiv) were placed in a 5 mL microwave vial and dry THF added (1 mL) under a blanket of argon. For coupling partners containing acidic hydrogens additional DABAL-Me3 (total of 410 mg, 1.6 equiv) was used. The vial was promptly capped and placed in a CEM Discover microwave reactor. After irradiation (290 W, 130 C, 8 min) and programmed cool down (ca. 20 min). The reactions were quenched by cautious addition of HCl (2 M, 4 mL) or aqueous solutions of Rochelle salt (saturated potassium sodium tartrate, 4 mL) (CARE: methane liberated). Extraction with dichloromethane, drying (MgSO4) and evaporation frequently provided the pure products directly. If purification was required column chromatography 3:2 to 2:3 hexane:EtOAc was used for amides lacking highly polar functional groups (CH2Cl2 with 2 % v/v MeOH was used for amides bearing pendant amines, alcohols and other polar functional groups).

The chemical industry reduces the impact on the environment during synthesis Methyl Diphenylacetate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Dubois, Nathalie; Glynn, Daniel; McInally, Thomas; Rhodes, Barrie; Woodward, Simon; Irvine, Derek J.; Dodds, Chris; Tetrahedron; vol. 69; 46; (2013); p. 9890 – 9897;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 3469-00-9,Some common heterocyclic compound, 3469-00-9, name is Methyl Diphenylacetate, molecular formula is C15H14O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of diisopropylamine (0.17 mL, 1.19 mmol) in THF (1 mL) was added n-BuLi (2.5 M in hexane, 0.4 mL, 0.994 mmol) at -78 C. The reaction mixture was stirred at this temperature for 30 min, followed by stirring at -5 C for 30 min. Then, the reaction mixture was cooled to -78 C and diphenyl methylacetate (S6) (0.15 g, 0.66 mmol) in THF (2 mL) was added. After stirring at -78 C for 15 min, (E)-4,6-iodoheptadiene (S11) (0.16 g, 0.72 mmol) was added. The resulting solution was stirred at rt overnight. The reaction mixture was quenched with satd aq NH4Cl (10 mL) and extracted with EtOAc (2 x 50 mL). The extract was washed with water and brine, dried (MgSO4), filtered, and concentrated by rotary evaporation. Column chromatography of the residue (20:1 hexane/EtOAc) gave S12 (120 mg, 63%) as colorless oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl Diphenylacetate, its application will become more common.

Reference:
Article; Chandrasekhar; Ryu, Jae-Sang; Tetrahedron; vol. 68; 24; (2012); p. 4805 – 4812;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3469-00-9 name is Methyl Diphenylacetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 3469-00-9

2.1 Methyl 2-(cyclohex-2-enyl)-2,2-diphenylacetate (1) Lithium di-isopropylamide (LDA) was generated in situ by slow addition of n-BuLi (1.65 mL, 1.6 mol/L, 2.65 mmol, 1.3 equiv.) to the solution of di-isopropylamine (371 mg, 2.87 mmol, 1.2 equiv.) in THF (4 mL) and stirred for 0.5 h at -78 C. Methyl diphenylacetate (500 mg, 2.21 mmol) in THF (5 mL) was added slowly over 1 h at the same temperature and stirred for an additional 1 h. 3-Bromocyclohexene (391.3 mg, 2.431 mmol, 1.1 equiv.) was added slowly to the reaction mixture, allowed to warm up at room temperature freely and stirred for 24 h. Quenched with aqueous HCl (5 mL, 1 mol/L), stirred and partitioned between H2O (10 mL) and CH2Cl2 (3 *20 mL), the organic layer was combined, dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure and purified by column chromatography with EtOAc/n-hexane (1/20, v/v) afforded 1 as a clear colorless oil (500 mg, 86%) which was crystallized from n-hexane. 1H NMR (400 MHz, CDCl3): delta 7.29-7.26 (m, 10 H, 2Ph-H), 5.67-5.62 (m, 2H, 2′,3′-H), 3.81 (m, 1H, 2-H), 3.62 (s, 3H, Me), 1.88-1.01 (m, 6H, 4′,5′,6′-H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl Diphenylacetate, and friends who are interested can also refer to it.

Reference:
Article; Sohail, Muhammad; Wang, Yao-Feng; Wu, Shao-Xiang; Zeng, Wei; Guo, Ji-Yi; Chen, Fu-Xue; Chinese Chemical Letters; vol. 24; 8; (2013); p. 695 – 698;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

3469-00-9, name is Methyl Diphenylacetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 3469-00-9

General procedure: 4.2 General procedures: A. Microwave. Neat samples of amine (1.00 mmol) and carboxylic derivative (methyl ester or acid, 1.00 mmol) and DABAL-Me3 (202 mg, 0.8 equiv) were placed in a 5 mL microwave vial and dry THF added (1 mL) under a blanket of argon. For coupling partners containing acidic hydrogens additional DABAL-Me3 (total of 410 mg, 1.6 equiv) was used. The vial was promptly capped and placed in a CEM Discover microwave reactor. After irradiation (290 W, 130 C, 8 min) and programmed cool down (ca. 20 min). The reactions were quenched by cautious addition of HCl (2 M, 4 mL) or aqueous solutions of Rochelle salt (saturated potassium sodium tartrate, 4 mL) (CARE: methane liberated). Extraction with dichloromethane, drying (MgSO4) and evaporation frequently provided the pure products directly. If purification was required column chromatography 3:2 to 2:3 hexane:EtOAc was used for amides lacking highly polar functional groups (CH2Cl2 with 2 % v/v MeOH was used for amides bearing pendant amines, alcohols and other polar functional groups).

Statistics shows that 3469-00-9 is playing an increasingly important role. we look forward to future research findings about Methyl Diphenylacetate.

Reference:
Article; Dubois, Nathalie; Glynn, Daniel; McInally, Thomas; Rhodes, Barrie; Woodward, Simon; Irvine, Derek J.; Dodds, Chris; Tetrahedron; vol. 69; 46; (2013); p. 9890 – 9897;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

3469-00-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3469-00-9, name is Methyl Diphenylacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 13: Preparation of 3-(S) – methyl- 2,2- diphenyl-2 -( 1-tosyl pyrrolidin -3- yl) acetate:2,2-diphenyl acetic acid methyl ester (22.6 grams) was added to a stirred suspension of sodium hydride (4 grams of a 60% suspension in oil) in anhydrous toluene (250 ml). The mixture was heated to 55-600C and stirred for 1 hour. The reaction mixture was cooled to 25-300C and 3-(S)-I -tosyl-3-tosyloxypyrrolidine (39.5 grams) was added to the above mixture in portions and the mixture was heated to reflux temperature. The reaction mixture was stirred for 3 hours at reflux temperature. The reaction mixture was cooled to 25-30C and quenched with methanol. The organic layer was washed with 5% aqueous sodium hydroxide then dried with sodium sulphate. Distilled off the toluene under reduced pressure to get solid. The obtained solid was purified by using ethyl acetate to give title compound as crystalline solid.Yield: 25 grams; M.R: 183-186C

The synthetic route of Methyl Diphenylacetate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; VENKATESH, Mummadi; WO2008/126106; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics