Category: 34637-22-4

Giuliani, Marta; Faroldi, Federica; Morelli, Laura; Torre, Enza; Lombardi, Grazia; Fallarini, Silvia; Sansone, Francesco; Compostella, Federica published the artcile< Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides>, Related Products of 34637-22-4, the main research area is glycocalixarene mannosamine conformational antigen vaccine; aminoglycoside calixarene cluster preparation Streptococcus pneumoniae capsular polysaccharide antibody; Calixarenes; Multivalent ligands; Saccharide antigens; Serotype 19F; Streptococcus pneumoniae.

Calixarenes are promising scaffolds for an efficient clustered exposition of multiple saccharide antigenic units. Herein we report the synthesis and biol. evaluation of a calix[6]arene functionalized with six copies of the trisaccharide repeating unit of Streptococcus pneumoniae (SP) serotype 19F. This system has demonstrated its ability to efficiently inhibit the binding between the native 19F capsular polysaccharide and anti-19F antibodies, despite a low number of exposed saccharide antigens, well mimicking the epitope presentations in the polysaccharide. The calix[6]arene mobile scaffold has been selected for functionalization with SP 19F repeating unit after a preliminary screening of four model glycocalixarenes, functionalized with N-acetyl mannosamine, and differing in the valency and/or conformational properties. This work is a step forward towards the development of new fully synthetic calixarenes comprising small carbohydrate antigens as potential carbohydrate-based vaccine scaffolds.

Bioorganic Chemistry published new progress about Streptococcus pneumoniae. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Related Products of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giuliani, Marta; Faroldi, Federica; Morelli, Laura; Torre, Enza; Lombardi, Grazia; Fallarini, Silvia; Sansone, Francesco; Compostella, Federica published the artcile< Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides>, Related Products of 34637-22-4, the main research area is glycocalixarene mannosamine conformational antigen vaccine; aminoglycoside calixarene cluster preparation Streptococcus pneumoniae capsular polysaccharide antibody; Calixarenes; Multivalent ligands; Saccharide antigens; Serotype 19F; Streptococcus pneumoniae.

Calixarenes are promising scaffolds for an efficient clustered exposition of multiple saccharide antigenic units. Herein we report the synthesis and biol. evaluation of a calix[6]arene functionalized with six copies of the trisaccharide repeating unit of Streptococcus pneumoniae (SP) serotype 19F. This system has demonstrated its ability to efficiently inhibit the binding between the native 19F capsular polysaccharide and anti-19F antibodies, despite a low number of exposed saccharide antigens, well mimicking the epitope presentations in the polysaccharide. The calix[6]arene mobile scaffold has been selected for functionalization with SP 19F repeating unit after a preliminary screening of four model glycocalixarenes, functionalized with N-acetyl mannosamine, and differing in the valency and/or conformational properties. This work is a step forward towards the development of new fully synthetic calixarenes comprising small carbohydrate antigens as potential carbohydrate-based vaccine scaffolds.

Bioorganic Chemistry published new progress about Streptococcus pneumoniae. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Related Products of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Shuai; Zhang, Shuo-Qing; Saeednia, Borna; Zhou, Jiawang; Anna, Jessica M.; Hong, Xin; Molander, Gary A. published the artcile< Diastereoselective olefin amidoacylation via photoredox PCET/nickel-dual catalysis: reaction scope and mechanistic insights>, Product Details of C11H15NO3, the main research area is lactam preparation regioselective diastereoselective DFT Gibbs free energy; alkene iridium nickel photocatalyst amidoacylation cyclization.

Synthesis of cyclic amides such as I via regio- and diastereoselective amidoacylation of unactivated olefins by using photoredox proton-coupled electron transfer (PCET)/Ni dual-catalysis was developed. Various acyl electrophiles were compatible, including alkyl- and aryl acyl chlorides and anhydrides, as well as in situ activated carboxylic acids. Hammett studies and other mechanistic experiments to elucidate features of the diastereoselectivity, a transient absorption study of the PCET step, as well as computational evidence, provide an in-depth understanding of the disclosed transformation.

Chemical Science published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Product Details of C11H15NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Shuai; Zhang, Shuo-Qing; Saeednia, Borna; Zhou, Jiawang; Anna, Jessica M.; Hong, Xin; Molander, Gary A. published the artcile< Diastereoselective olefin amidoacylation via photoredox PCET/nickel-dual catalysis: reaction scope and mechanistic insights>, Product Details of C11H15NO3, the main research area is lactam preparation regioselective diastereoselective DFT Gibbs free energy; alkene iridium nickel photocatalyst amidoacylation cyclization.

Synthesis of cyclic amides such as I via regio- and diastereoselective amidoacylation of unactivated olefins by using photoredox proton-coupled electron transfer (PCET)/Ni dual-catalysis was developed. Various acyl electrophiles were compatible, including alkyl- and aryl acyl chlorides and anhydrides, as well as in situ activated carboxylic acids. Hammett studies and other mechanistic experiments to elucidate features of the diastereoselectivity, a transient absorption study of the PCET step, as well as computational evidence, provide an in-depth understanding of the disclosed transformation.

Chemical Science published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Product Details of C11H15NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics