Category: 34637-22-4

Sakai, Holt A.; MacMillan, David W. C. published the artcile< Nontraditional Fragment Couplings of Alcohols and Carboxylic Acids: C(sp3)-C(sp3) Cross-Coupling via Radical Sorting>, Reference of 34637-22-4, the main research area is amide preparation; alc carboxylic acid nontraditional fragment coupling radical sorting photocatalyst.

In this report, the C(sp3)-C(sp3) cross-coupling of alcs. and carboxylic acids through the dual combination of N-heterocyclic carbene (NHC)-mediated deoxygenation and hypervalent iodine-mediated decarboxylation were described. This mild and practical Ni-catalyzed radical-coupling protocol was employed to prepare a wide array of alkyl-alkyl cross-coupled products, including highly congested quaternary carbon centers from the corresponding tertiary alcs. or tertiary carboxylic acids. Synthetic applications of this methodol. to alc. C1-alkylation and formal homologation, as well as to the late-stage functionalization of drugs, natural products, and biomols. were demonstrated.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Reference of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Chaoyu; Bei, Wenfeng; Li, Wanting; Wang, Dongwei; Liu, Yuqin; Gong, Zile; Zeng, Kailin; Feng, Ruokun; Huang, Xianqiang; Qi, Chenze published the artcile< Cobalt-catalyzed O-arylation of N-protected amino alcohols with arenes via cross-dehydrogenative C-O coupling strategy: Direct access to aryloxyamines>, Category: esters-buliding-blocks, the main research area is amino alc aromatic amide cobalt catalyst cross dehydrogenative coupling; aryloxyamine regioselective preparation.

An efficient Co(II)-catalyzed cross-dehydrogenative C-O coupling strategy for the arylation of N-protected amino alcs., including 1,2-, 1,3- and 1,4-amino alcs., branched amino alcs. and cyclic amino alcs. with different amides derivatives was developed, affording a wide range of corresponding aryloxyamines compounds with excellent convertibility in moderate to good yields, which are of great interest in medicinal and pharmaceutical chem. Furthermore, this reaction system could be further applied to the preparation of potential bioactive mols.

Tetrahedron Letters published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chang, Chun-Wei; Wu, Chia-Hui; Lin, Mei-Huei; Liao, Pin-Hsuan; Chang, Chun-Chi; Chuang, Hsiao-Han; Lin, Su-Ching; Lam, Sarah; Verma, Ved Prakash; Hsu, Chao-Ping; Wang, Cheng-Chung published the artcile< Establishment of Guidelines for the Control of Glycosylation Reactions and Intermediates by Quantitative Assessment of Reactivity>, Electric Literature of 34637-22-4, the main research area is predicted stereocontrolled glycosylation relative reactivity thioglycoside; carbohydrates; diastereoselectivity; glycosylation.

Stereocontrolled chem. glycosylation remains a major challenge despite vast efforts reported over many decades and so far still mainly relies on trial and error. Now it is shown that the relative reactivity value (RRV) of thioglycosides is an indicator for revealing stereoselectivities according to four types of acceptors. Mechanistic studies show that the reaction is dominated by two distinct intermediates: glycosyl triflates and glycosyl halides from N-halosuccinimide (NXS)/TfOH. The formation of glycosyl halide is highly correlated with the production of α-glycoside. These findings enable glycosylation reactions to be foreseen by using RRVs as an α/β-selectivity indicator and guidelines and rules to be developed for stereocontrolled glycosylation.

Angewandte Chemie, International Edition published new progress about Diastereoselective synthesis. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Electric Literature of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Yanxin; Zhang, Han; Zhao, Ying; Guo, Zhongwu; Gao, Jian published the artcile< Efficient Strategy for α-Selective Glycosidation of D-Glucosamine and Its Application to the Synthesis of a Bacterial Capsular Polysaccharide Repeating Unit Containing Multiple α-Linked GlcNAc Residues>, Formula: C11H15NO3, the main research area is stereoselective glycosylation catalyst aminoglycoside preparation disaccharide oligosaccharide.

An efficient α-selective glycosylation method was developed for the synthesis of 2-deoxy-2-amino-D-glucosides based on synergetic α-directing effects of the TolSCl/AgOTf promotion system and the functional groups at the corresponding azido donor 6-O-position to exert steric β-shielding effect or remote participation in the glycosylation reaction. Its practicability was verified with a wide range of monosaccharide glycosyl acceptors and the first, one-pot synthesis of the challenging pentasaccharide repeating unit of an Acinetobacter baumannii K47 capsular polysaccharide.

Organic Letters published new progress about Acinetobacter baumannii. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Formula: C11H15NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abdel-Maksoud, Mohammed S.; Ali, Eslam M. H.; Ammar, Usama M.; Mersal, Karim I.; Yoo, Kyung Ho; Oh, Chang-Hyun published the artcile< Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF>, Synthetic Route of 34637-22-4, the main research area is cancer anticancer BRAF inhibitors kinase inhibitor SAR; Anticancer; B-RAF inhibitors; Kinase inhibitor; Pyrrolo[2,3-b]pyridine; SAR.

Several pyrrolo[2,3-b]pyridine-based B-RAF inhibitors are well known and some of them are currently FDA approved as anticancer agents. Based on the structure of these FDA approved V600EB-RAF inhibitors, two series of pyrrolo[2,3-b]pyridine scaffold were designed and synthesized in attempt to develop new potent V600EB-RAF inhibitors. The 38 synthesized compounds were biol. evaluated for their V600EB-RAF inhibitory effect at single dose (10 μM). Compounds with high percent inhibition were tested to determine their IC50 over V600EB-RAF. Compounds 34e and 35 showed the highest inhibitory effect with IC50 values of 0.085 μM and 0.080 μM, resp. Headed for excessive biol. evaluation, the synthesized derivatives were tested over sixty diverse human cancer cell lines. Only compound 35(I) emerged as a potent cytotoxic agent against different panel of human cancer cell lines.

Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Synthetic Route of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bihani, Manisha; Bora, Pranjal P.; Nachtegaal, Maarten; Jasinski, Jacek B.; Plummer, Scott; Gallou, Fabrice; Handa, Sachin published the artcile< Microballs Containing Ni(0)Pd(0) Nanoparticles for Highly Selective Micellar Catalysis in Water>, COA of Formula: C11H15NO3, the main research area is nickel palladium nanoparticle selective micellar catalysis water.

Both Ni(0) complexes and nanoparticles (NPs) are unstable in water, which poses a significant hindrance to their application in aqueous synthetic catalysis. To overcome these barriers, ligated Ni(0) nanoparticles (diameter <1 nm) containing a min. amount of Pd(0) in the microballs formed of amphiphile PS-750-M are developed and applied in the highly selective carbamate cleavage. Selectivity and functional group tolerance are thoroughly investigated. Control experiments revealed the importance of an individual component of the nanocatalyst. Use of our proline-based amphiphile PS-750-M is critical for achieving microball architecture, the stability of nanoparticles, and desired catalytic activity. Once formed, microballs can be isolated and stored at ambient temperature Catalyst is thoroughly characterized by XPS, SEM, high-resolution transmission electron microscopy, thermogravimetric anal., IR, and cyclic voltammetry. For selective catalysis, zero oxidation state of both Ni and Pd is crucial. On the basis of catalyst characterization and control experiments, the plausible reaction mechanism is proposed. ACS Catalysis published new progress about Binding energy. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, COA of Formula: C11H15NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bihani, Manisha; Bora, Pranjal P.; Nachtegaal, Maarten; Jasinski, Jacek B.; Plummer, Scott; Gallou, Fabrice; Handa, Sachin published the artcile< Microballs Containing Ni(0)Pd(0) Nanoparticles for Highly Selective Micellar Catalysis in Water>, COA of Formula: C11H15NO3, the main research area is nickel palladium nanoparticle selective micellar catalysis water.

Both Ni(0) complexes and nanoparticles (NPs) are unstable in water, which poses a significant hindrance to their application in aqueous synthetic catalysis. To overcome these barriers, ligated Ni(0) nanoparticles (diameter <1 nm) containing a min. amount of Pd(0) in the microballs formed of amphiphile PS-750-M are developed and applied in the highly selective carbamate cleavage. Selectivity and functional group tolerance are thoroughly investigated. Control experiments revealed the importance of an individual component of the nanocatalyst. Use of our proline-based amphiphile PS-750-M is critical for achieving microball architecture, the stability of nanoparticles, and desired catalytic activity. Once formed, microballs can be isolated and stored at ambient temperature Catalyst is thoroughly characterized by XPS, SEM, high-resolution transmission electron microscopy, thermogravimetric anal., IR, and cyclic voltammetry. For selective catalysis, zero oxidation state of both Ni and Pd is crucial. On the basis of catalyst characterization and control experiments, the plausible reaction mechanism is proposed. ACS Catalysis published new progress about Binding energy. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, COA of Formula: C11H15NO3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giuliani, Marta; Faroldi, Federica; Morelli, Laura; Torre, Enza; Lombardi, Grazia; Fallarini, Silvia; Sansone, Francesco; Compostella, Federica published the artcile< Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides>, Related Products of 34637-22-4, the main research area is glycocalixarene mannosamine conformational antigen vaccine; aminoglycoside calixarene cluster preparation Streptococcus pneumoniae capsular polysaccharide antibody; Calixarenes; Multivalent ligands; Saccharide antigens; Serotype 19F; Streptococcus pneumoniae.

Calixarenes are promising scaffolds for an efficient clustered exposition of multiple saccharide antigenic units. Herein we report the synthesis and biol. evaluation of a calix[6]arene functionalized with six copies of the trisaccharide repeating unit of Streptococcus pneumoniae (SP) serotype 19F. This system has demonstrated its ability to efficiently inhibit the binding between the native 19F capsular polysaccharide and anti-19F antibodies, despite a low number of exposed saccharide antigens, well mimicking the epitope presentations in the polysaccharide. The calix[6]arene mobile scaffold has been selected for functionalization with SP 19F repeating unit after a preliminary screening of four model glycocalixarenes, functionalized with N-acetyl mannosamine, and differing in the valency and/or conformational properties. This work is a step forward towards the development of new fully synthetic calixarenes comprising small carbohydrate antigens as potential carbohydrate-based vaccine scaffolds.

Bioorganic Chemistry published new progress about Streptococcus pneumoniae. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Related Products of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giuliani, Marta; Faroldi, Federica; Morelli, Laura; Torre, Enza; Lombardi, Grazia; Fallarini, Silvia; Sansone, Francesco; Compostella, Federica published the artcile< Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides>, Related Products of 34637-22-4, the main research area is glycocalixarene mannosamine conformational antigen vaccine; aminoglycoside calixarene cluster preparation Streptococcus pneumoniae capsular polysaccharide antibody; Calixarenes; Multivalent ligands; Saccharide antigens; Serotype 19F; Streptococcus pneumoniae.

Calixarenes are promising scaffolds for an efficient clustered exposition of multiple saccharide antigenic units. Herein we report the synthesis and biol. evaluation of a calix[6]arene functionalized with six copies of the trisaccharide repeating unit of Streptococcus pneumoniae (SP) serotype 19F. This system has demonstrated its ability to efficiently inhibit the binding between the native 19F capsular polysaccharide and anti-19F antibodies, despite a low number of exposed saccharide antigens, well mimicking the epitope presentations in the polysaccharide. The calix[6]arene mobile scaffold has been selected for functionalization with SP 19F repeating unit after a preliminary screening of four model glycocalixarenes, functionalized with N-acetyl mannosamine, and differing in the valency and/or conformational properties. This work is a step forward towards the development of new fully synthetic calixarenes comprising small carbohydrate antigens as potential carbohydrate-based vaccine scaffolds.

Bioorganic Chemistry published new progress about Streptococcus pneumoniae. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Related Products of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Giuliani, Marta; Faroldi, Federica; Morelli, Laura; Torre, Enza; Lombardi, Grazia; Fallarini, Silvia; Sansone, Francesco; Compostella, Federica published the artcile< Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides>, Related Products of 34637-22-4, the main research area is glycocalixarene mannosamine conformational antigen vaccine; aminoglycoside calixarene cluster preparation Streptococcus pneumoniae capsular polysaccharide antibody; Calixarenes; Multivalent ligands; Saccharide antigens; Serotype 19F; Streptococcus pneumoniae.

Calixarenes are promising scaffolds for an efficient clustered exposition of multiple saccharide antigenic units. Herein we report the synthesis and biol. evaluation of a calix[6]arene functionalized with six copies of the trisaccharide repeating unit of Streptococcus pneumoniae (SP) serotype 19F. This system has demonstrated its ability to efficiently inhibit the binding between the native 19F capsular polysaccharide and anti-19F antibodies, despite a low number of exposed saccharide antigens, well mimicking the epitope presentations in the polysaccharide. The calix[6]arene mobile scaffold has been selected for functionalization with SP 19F repeating unit after a preliminary screening of four model glycocalixarenes, functionalized with N-acetyl mannosamine, and differing in the valency and/or conformational properties. This work is a step forward towards the development of new fully synthetic calixarenes comprising small carbohydrate antigens as potential carbohydrate-based vaccine scaffolds.

Bioorganic Chemistry published new progress about Streptococcus pneumoniae. 34637-22-4 belongs to class esters-buliding-blocks, and the molecular formula is C11H15NO3, Related Products of 34637-22-4.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics