S News New learning discoveries about 344-14-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 344-14-9, name is Dimethyl 2-fluoromalonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 344-14-9, HPLC of Formula: C5H7FO4

General procedure: The solution of 25% NaOMe in methanol (10.28 g, 190.38 mmol) was diluted with methanol(50 ml) under N2 atm and cooled to 0 0C. To this, compound 1a (14.90 g, 95.19 mmol) followedby compound 6 (10 g, 105.77 mmol) were added and stirred the reaction mixture at roomtemperature for 16 h. The progress of the reaction was monitored by TLC (10% Ethyl acetatein petroleum ether) showed completion of the reaction. After completion of the reaction; thereaction mixture was evaporated and solid was dissolved in H2O and acidified with Conc.HCl(~ pH 2), to give the white solid. The resulting solid was filtered and washed with water anddried under vacuum give the pure compound 7a (10 g; 48.78 mmol, 72%) as an off white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sambaiah; Mallesham, Poosa; Shiva Kumar; Bobde, Yamini; Hota, Prasanta Kumar; Yennam, Satyanarayana; Ghosh, Balaram; Behera, Manoranjan; Synlett; vol. 30; 5; (2019); p. 586 – 592;,
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26-Sep News The important role of 344-14-9

According to the analysis of related databases, 344-14-9, the application of this compound in the production field has become more and more popular.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 344-14-9 as follows. Computed Properties of C5H7FO4

A mixture of 2-fluoro-4-amidinopyridine hydrochloride (1.17 g, 6.662 mmol), dimethyl fluoromalonate (1 g, 6.662 mmol), DBU (3.35 mL, 22.4 mmol) and MeOH (50 mL) was stirred at room temperature overnight. The crude reaction mixture was evaporated under reduced pressure to yield a brown oil. A 2 N HC1 solution was cautiously added and the precipitate was collected by filtration, washed with water and dried in a vacuum oven to give the title compound (0.992 g, 66% yield). LCMS: RT 2.91 min, MI 225, Method (4LCMS1).

According to the analysis of related databases, 344-14-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; CARSWELL, Emma, L.; CHARLES, Mark, David; COCHI, Anne; DUGAN, Benjamin, J.; EKWURU, Chukuemeka, Tennyson; ELUSTONDO, Fred; FOWLER, Katherine, M.; LEROUX, Frederic, Georges, Marie; MONCK, Nathaniel, J.T.; OTT, Gregory, R.; ROFFEY, Jonathan, R.; SIDHU, Gurwinder; TREMAYNE, Neil; (305 pag.)WO2018/55402; (2018); A1;,
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9/14/21 News The important role of 344-14-9

The synthetic route of 344-14-9 has been constantly updated, and we look forward to future research findings.

Reference of 344-14-9, A common heterocyclic compound, 344-14-9, name is Dimethyl 2-fluoromalonate, molecular formula is C5H7FO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: In a 50 mL two-necked flask containing dichloromethane (10 mL) were added the amine (17 mmol) followed by the aldehyde (15 mmol) and the resulting reaction mixture was allowed to stir at rt for 2 h, before the fluorinated dicarbonyl system (10 mmol) was added. The reaction mixture was stirred at rt for 16 h, evaporated and the residue dissolved in dichloromethane (20 mL), washed with distilled water (2×20 mL), dried over magnesium sulfate and evaporated, to give the desired product. Further purification by distillation or column chromatography eluting from hexane/ethyl acetate was carried out when appropriate. Analytical and spectroscopic data for each individual compound are listed below. For NMR data only resonances of one diastereoisomer or conformer is given for clarity.

The synthetic route of 344-14-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lisse, Etienne; Sandford, Graham; Journal of Fluorine Chemistry; vol. 206; (2018); p. 117 – 124;,
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9/14/2021 News Some tips on 344-14-9

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference of 344-14-9, A common heterocyclic compound, 344-14-9, name is Dimethyl 2-fluoromalonate, molecular formula is C5H7FO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Part A: 5-Fluoro-4,6-dihydroxy-2-methylpyrimidine A solution of 200 ml. of 25% wt sodium methoxide in methanol (0.84 mol) was diluted with an additional 200 ml. of methanol. Acetamidine-HCI (40 g , 0.42 mol) was added to the sodium methoxide solution (white precipitate formed), followed by addition of dimethyl fluoromalonate (70 g, 0.46 mol). The contents were stirred at room temperature overnight, then concentrated in vacuo to dryness. The resulting residue was redissolved in hot water (300 ml_). After cooling the aqueous solution to room temperature, concentrated HCI was added slowly until crystal formation (fine white prisms) took place at about pH 5. Concentrated HCI was added dropwise until pH 3, and then the contents were filtered. The isolated crystals were rinsed with 1 M HCI and dried under vacuum to provide 5-fluoro-4,6-dihydroxy-2-methylpyrimidine (65.5 g, >100%). LCMS: (M+H)+: 145.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED; AUBART, Kelly, Marshall; GILLIAN, Jason, Michael; QIN, Donghui; MCKEOWN, Robert, Rahn; WILLIAMS, Glenn, R.; WO2013/82388; (2013); A1;,
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6-Sep-2021 News New learning discoveries about 344-14-9

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 344-14-9.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-14-9, name is Dimethyl 2-fluoromalonate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H7FO4

2-Hydroxy-3-fluoro-8,8-dimethyl-6,7,8,9-tetrahydro-4H-pyrimido[1 ,2- a]pyrimidin-4-one can be prepared in the following way. A suspension of 5 g of 4,4-dimethyl-1 ,4,5,6-tetrahydropyrimidin-2- amine, 29 g of dimethyl fluoromalonate and 3.9 g of sodium methoxide is heated at 100C for 3 hours. The reaction medium is concentrated to dryness under reduced pressure. The residue obtained is taken up with ethyl ether. The solid formed is filtered off and then dried. 10 ml of water are added to the solid obtained, and the resulting mixture is cooled on ice, before acidification to pH 5-6 by adding concentrated hydrochloric acid (25%). The suspension is filtered and then the solid is washed with 5 ml of water and then dried under vacuum over P2O5, so as to give 3.15 g of 2-Hydroxy-3-fluoro-8,8-dimethyl- 6,7,8,9-tetrahydro-4H-pyrimido[1 ,2-a]pyrimidin-4-one, in the form of a yellow powder, the characteristics of which are the following: Mass spectrum (method A) (ES+/-) [M+H]+: m/z 232; [M-H]-: m/z 230; Tr (min) = 0.86

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 344-14-9.

Reference:
Patent; SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; LETALLEC, Jean-Philippe; MARCINIAK, Gilbert; RONAN, Baptiste; VIVET, Bertrand; WO2013/190510; (2013); A2;,
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6-Sep-2021 News Discovery of 344-14-9

According to the analysis of related databases, 344-14-9, the application of this compound in the production field has become more and more popular.

Synthetic Route of 344-14-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 344-14-9 as follows.

Part A: 5-Fluoro-2-(fluoromethyl)-6-hydroxy-4(1 H)-pyrimidinone 2-Fluoro-acetamidine hydrochloride salt (1 1 .2 g, 100 mmol) and dimethyl fluoromalonate (15 g, 100 mmol) in anhydrous methanol (300 mL) were treated with solid NaOMe (16.2 g, 300 mmol) and heated to 50 C with stirring. When LCMS showed formation of the desired product, the solvent was evaporated to dryness, and the residue was neutralized with concentrated HCI (20 mL). The white precipitate was collected by filtration to give 5-fluoro-2-(fluoromethyl)-6-hydroxy-4(1 H)-pyrimidinone (100% yield). LCMS: (M+H)+: 163.1.

According to the analysis of related databases, 344-14-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED; AUBART, Kelly, Marshall; GILLIAN, Jason, Michael; QIN, Donghui; MCKEOWN, Robert, Rahn; WILLIAMS, Glenn, R.; WO2013/82388; (2013); A1;,
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Brief introduction of Dimethyl 2-fluoromalonate

The synthetic route of 344-14-9 has been constantly updated, and we look forward to future research findings.

344-14-9, name is Dimethyl 2-fluoromalonate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C5H7FO4

Intermediate 345 A: Methyl 2-fluoropent-4-ynoate In a 20 mL microwave vial, a mixture of dimethyl 2-fluoromalonate (900 mg, 6.0 mmol) in DMA (5 mL) at room temperature with stirring, was treated with the slow addition of sodium hydride (240 mg, 6 mmol, 60%) at 0 C. The mixture was stirred for 10 minutes, then added 3-bromoprop-l-yne (743 mg, 5.0 mmol, 80% in xylenes) and the mixture was stirred vigorously at 25 C for 1.5 hours. TLC shows consumption of the bromide. A syringe needle was placed through the septum to allow gases to vent, then the mixture was heated at 90 C for 20 hours. The reaction was quenched with the careful addition under nitrogen of saturated NH4CI solution (0.5 mL), and extracted with ethyl acetate (3 X 25 mL). The combined extracts were dried over Na2S04 to give a few ml of a brown oil as crude product. The crude product was dissolved in ethyl acetate and rinsed 3 times with 10% LiCl to remove DMA. The organic layer was dried over sodium sulfate, and then concentrated to give an amber oil which was purified over silica gel in 9: 1 to 3 : 1 hexanes/EtOAc to afford methyl 2-fluoropent-4-ynoate (600 mg, 69% yield). NMR (400MHz, CHLOROFORM-d) delta 3.84 (s, 3H), 2.92-2.74 (m, 2H), 2.14-2.00 (m, 1H), 1.27 (d, J=5.3 Hz, 1H). LCMS 130.2 (M+H)+.

The synthetic route of 344-14-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GARDNER, Daniel S.; SANTELLA, Joseph B.; PAIDI, Venkatram Reddy; WU, Hong; DUNCIA, John V.; NAIR, Satheesh Kesavan; HYNES, John; (300 pag.)WO2016/210034; (2016); A1;,
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Continuously updated synthesis method about Dimethyl 2-fluoromalonate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.

Related Products of 344-14-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 344-14-9, name is Dimethyl 2-fluoromalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

163 mg (2 mmol) of ethylamine hydrochloride, 1.50 g (10 mmol) of dimethyl fluoromalonate, 212 mg (2 mmol) of sodium carbonate and 10 ml of ethanol were added to the reactor,The reaction was stirred at 50 C for 10 hours.Filtration, evaporation of ethanol, the remaining mixture was directly separated by column chromatography,310 mg of methyl alpha- (N-ethyl) carbamoyrifluoroacetate was obtained in a yield95%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Xi’an Modern Chemical Institute; Wang Lun; Lin Shuangzheng; Li Bingbo; Wang Yuemei; Yang Cuifeng; Wu Zongkai; Wei Tianqi; (5 pag.)CN104496737; (2017); B;,
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Brief introduction of 344-14-9

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.

Electric Literature of 344-14-9, The chemical industry reduces the impact on the environment during synthesis 344-14-9, name is Dimethyl 2-fluoromalonate, I believe this compound will play a more active role in future production and life.

General procedure: A test tube chargedwith MS 3A (40.0 mg, 200 mg/mmol) was flame-dried under reduced pressure using a heat gun. After cooling to room temperature, argon was re-filled, Schiff base 1 (11.1 mg, 0.02 mmol), THF (0.2 mL) andGd(OiPr)3 (0.2 M THF solution, 0.1 mL, 0.02 mmol) were added. The mixture was stirred at roomtemperature for 30 min to afford yellow suspension. THF was, then, removed under reduced pressure. Tothe test tube were added Y(OTf)3 (10.7 mg, 0.02 mmol) and THF (0.20 mL), and the mixture was stirred at room temperature for 30 min to afford the Gd(OiPr)3/Y(OTf)3/Schiff base = 1:1:1 catalyst in THF.Then, DMAP (2.4 mg, 0.02 mmol) was added, and THF was removed under reduced pressure. After drying the residue under reduced pressure for 1 h at room temperature, toluene (0.2 mL) and Et2O (0.4mL) were added. To the resulting red suspension were added 2-fluoromalonate 3 (0.35 mmol, 1.7 equiv)and meso-aziridine 2 (0.20 mmol, 1.0 equiv), and the mixture was stirred for 17-72 h at 40 C. After themixture was cooled to room temperature and diluted with AcOEt, saturated EDTA?2Na aq. was added.The organic layer was separated, and the aqueous layer was extracted with AcOEt and the organic layers were washed with brine. The organic layers were dried over Na2SO4. After filtration and evaporation, the obtained crude mixture was purified by silica gel column chromatography (AcOEt/hexane/CH2Cl2) togive a corresponding product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Fukagawa, Seiya; Xu, Yingjie; Anada, Masahiro; Yoshino, Tatsuhiko; Matsunaga, Shigeki; Heterocycles; vol. 94; 7; (2017); p. 1337 – 1350;,
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Analyzing the synthesis route of C5H7FO4

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 344-14-9, name is Dimethyl 2-fluoromalonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 344-14-9, Recommanded Product: 344-14-9

To a solution of methyl carbamimidothioate-^SC^)^ salt (45.90 g, 0.33 mol) and dimethyl 2-fluoromalonate (45.03 g, 0.30 mol) in MeOH (450 mL) at 0C was slowly added sodium methoxide (4.37 M in MeOH, 226 mL, 0.99 mol). The mixture was stirred for 16 hours at room temperature. The solution was concentrated under reduced pressure. The resulting slurry was diluted with water (50 mL) and acidified to about pH 2 by using a 6N HC1 solution. The resulting precipitate was collected, washed with water and dried under vacuum to give 5-fluoro-2-(methylthio)pyrimidine-4,6-diol (46.85 g, 88%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PTC THERAPEUTICS, INC.; LEE, Chang-Sun; BAIAZITOV, Ramil; CAO, Liangxian; DAVIS, Thomas, W.; DU, Wu; LIU, Ronggang; MOON, Young-choon; PAGET, Steven, D.; REN, Hongyu; SYDORENKO, Nadiya; WILDE, Richard, Gerald; WO2014/81906; (2014); A2;,
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