Category: 33491-30-4

Application of 33491-30-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33491-30-4 name is 8-Bromo-2H-chromen-2-one, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(3) Weigh 1.8g of Br-C8 (8.89mmol),0.28 g of Pd(PPh3)4 (0.24 mmol) in a SCHLENK reaction tube under N2 atmosphere,35 mL of toluene was added, and 3.53 g of tri-n-butyl 2-pyridinium (9.60 mmol) was added dropwise.The reaction was stirred at 110 C for 16 h. After completion of the reaction, the mixture was cooled to room temperature, and the solvent was evaporated under reduced pressure.It was separated and purified by silica gel column chromatography, and the mobile phase was dichloromethane.Finally, L-C8 was obtained as a white solid 1.49 g, and the yield was 83.2%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 8-Bromo-2H-chromen-2-one, and friends who are interested can also refer to it.

Reference:
Patent; Xi’an Jiaotong University; Zhou Guijiang; Feng Zhao; Yang Xiaolong; (40 pag.)CN109608502; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 33491-30-4, name is 8-Bromo-2H-chromen-2-one, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33491-30-4, Application In Synthesis of 8-Bromo-2H-chromen-2-one

General procedure: Under inert atmosphere (N2), in a 25 mL round bottom flask, Ar3Bi (0.208 mmol; 0.35 eq.), CsF (0.24 g: 1.8 mmol; 3 eq.), PPh3 (0.004 g: 0.018 mmol; 3 mol%), the aryl bromide (0.60 mmol; 1 eq.) was added to DMF (5 mL). The solution was warmed to 90 C prior addition of PEPPSI IPr (0.012 g: 0.018 mmol; 3 mol%). The reaction was monitored by GC/MS to follow the total consumption of the aryl bromide. Cooled to room temperature (RT), the reaction mixture was diluted by addition of diethyl ether (20 mL) and aqueous HCl 6 M (30 mL). After decantation, the aqueous solution was extracted with diethylether (2 * 20 mL). The collected organic phases were then washed with HCl 6 N (2 * 25 mL), water (25 mL) and brine (25 mL) prior drying over MgSO4. After concentration under reduced pressure, the resulting crude product was subjected to purification by column chromatography leading after concentration under reduced pressure to the title compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Cassirame, Benedicte; Condon, Sylvie; Pichon, Christophe; Journal of Molecular Catalysis A: Chemical; vol. 425; (2016); p. 94 – 102;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 33491-30-4, These common heterocyclic compound, 33491-30-4, name is 8-Bromo-2H-chromen-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: General synthetic procedure for 3a/3b/3c: 6-Bromocoumarin(0.5 g, 2.23 mmol), (4-ethynyl)benzaldehyde (0.29 g, 2.23 mmol)were dissolved in THF-triethylamine (1:1, v/v, 120 mL) and themixture was deaerated for 10 min with nitrogen bubbling and thenPd(PPh3)2Cl2 (31 mg, 2mol%), PPh3 (23 mg, 4 mol%)and CuI (8 mg,2mol%) were added. The solution was deaerated for an additional5 min; after that, reaction was left under nitrogen at 60C for 12 h.After completion of the reaction, the reaction mixture was cooledat room temperature and the solvent was evaporated. The crudeproduct was dissolved in CH2Cl2 and purified by a columnchromatography on a silica gel using (chloroform) as an eluent.

Statistics shows that 8-Bromo-2H-chromen-2-one is playing an increasingly important role. we look forward to future research findings about 33491-30-4.

Reference:
Article; Reddy, T. Sheshashena; Choi, Myung-Seok; Journal of Photochemistry and Photobiology A: Chemistry; vol. 351; (2018); p. 108 – 114;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics