Category: 3319-31-1

Tashi, Maryam; Shafiee, Behnaz; Sakamaki, Yoshie; Hu, Ji-Yun; Heidrick, Zachary; Khosropour, Ahmad R.; Beyzavi, M. Hassan published an article in 2018, the title of the article was Micro-flow nanocatalysis: synergic effect of TfOH@SPIONs and micro-flow technology as an efficient and robust catalytic system for the synthesis of plasticizers.Related Products of 3319-31-1 And the article contains the following content:

The combination of continuous flow technol. with immobilizing of only 0.13 mol% of triflic acid (TfOH) on silica-encapsulated superparamagnetic iron oxide nanoparticles (SPIONs) under solvent-free conditions successfully provided a powerful, efficient, and eco-friendly route for the synthesis of plasticizers. The turnover frequency value in micro-flow conditions varied in the range of 948.7 to 7384.6 h-1 compared to 403.8 to 3099 h-1 for in-flask. This technique works efficiently, encouraging future applications of micro-flow nano-catalysis in green chem. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Related Products of 3319-31-1

The Article related to robust micro flow nanocatalyst catalytic system plasticizer, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Related Products of 3319-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 25, 2021, Yuan, Baoling; Wang, Yunhao; Wang, Man; Gou, Gaozhang; Li, Liangchun published an article.HPLC of Formula: 3319-31-1 The title of the article was Metal-organic frameworks as recyclable catalysts for efficient esterification to synthesize traditional plasticizers. And the article contained the following:

Practically the traditional plasticizers are produced via homogeneous esterification reaction in millions of tons annually as additives for modulating the properties of polymeric materials, facing great environment pressure such as a huge amount of wastewater produced to remove the detrimental metal catalyst. In this work, a series of MOFs, MIL-101, MIL-125, MIL-125-NH2, UiO-66, UiO-66-NH2, and UiO-66-SO3H, have been synthesized and employed as heterogeneous catalysts for the syntheses of plasticizers. MIL-125 and MIL-125-NH2 were found to show the superior catalytic efficiency compared with other MOFs. Catalyzed by only 1.0 mol% of MIL-125 within 1.0 h at 190°C, the heterogeneous reaction achieved 99.9% yield of di-(2-ethylhexyl)terephthalate (DOTP). In addition, MIL-125 also showed excellent catalytic performance for the syntheses of other plasticizers (DOP, TOTM, DOA and DOS). The control experiments demonstrated that the titanium metal nodes of the MOFs dominate this kind of esterification reaction while functional groups on the ligands and structural defects give a certain pos. effect. MIL-125 has been proved to be a heterogeneous catalyst with high efficiency and good recyclability, mitigating the pollution and promising for economic and environmental friendliness in the practical production of traditional plasticizers. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).HPLC of Formula: 3319-31-1

The Article related to metal organic framework esterification catalyst traditional plasticizer, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.HPLC of Formula: 3319-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 6, 2018, Cody, Robert B.; Fouquet, Thierry published an article.Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was “Reverse Kendrick Mass Defect Analysis”: Rotating Mass Defect Graphs to Determine Oligomer Compositions for Homopolymers. And the article contained the following:

A new approach to determining the repeat unit compositions of homopolymers is reported in which a mass defect graph is rotated to zero slope to give a graph identical to a Kendrick mass defect graph. Because the Kendrick mass defect (KMD) is directly related to the elemental composition of the base unit, the process can be reversed. A mass defect graph (fractional m/z plotted against exact m/z) of a homopolymer can be rotated until the slope of the data points is zero. This is equivalent to finding a new constant factor by which the measured exact masses would have to be multiplied to create a Kendrick mass defect graph with zero slope. The elemental composition of the repeat unit can be determined by matching the new factor against the calculated factors for candidate compositions This approach provides some benefits over simply looking for pairs of peaks corresponding to oligomer units. The primary benefit is to assist in visualization of the data. Rotating the data points corresponding to polymer masses to zero slope makes it easier to visualize the polymer data, and it facilitates the graphical isolation of polymer masses from background interferences. The repeat unit composition is determined not from a single pair of peaks but from multiple data points, and systematic errors in mass assignment can be visualized as deviations from linearity. Resolution-enhanced KMD graphs can be constructed for the calculated repeat unit composition by using fractional base units. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to reverse kendrick mass defect analysis homopolymer oligomer dart ms, Physical Properties of Synthetic High Polymers: Analysis, Molecular Weight Determination, and Fractionation and other aspects.Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2017, Eljezi, Teuta; Pinta, Pierre; Richard, Damien; Pinguet, Jeremy; Chezal, Jean-Michel; Chagnon, Marie-Christine; Sautou, Valerie; Grimandi, Gael; Moreau, Emmanuel published an article.Reference of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line. And the article contained the following:

Phthalic acid esters have been widely used to improve the plasticity of PVC medical devices. They carry a high exposure risk for both humans and the environment in clin. situations. Our study focuses on the cytotoxicity of alternative plasticizers. Postulated primary metabolites were synthesized, not being com. available. Cytotoxicity assays were performed on L929 murine cells according to the ISO-EN 10993-5 standard design for the biocompatibility of medical devices. The tested concentrations of plasticizers (0.01, 0.05 and 0.1 mg/mL) covered the range likely to be found in biol. fluids coming into direct contact with the medical devices. DEHP, DINP and DINCH were cytotoxic at the highest concentration (0.1 mg/mL) for 7 days of exposure. Their corresponding metabolites were found to be more cytotoxic, for the same concentration By contrast, TOTM and its corresponding metabolite MOTM were not found to be cytotoxic. DEHA showed no cytotoxicity, but its corresponding monoester (MEHA) produced a cytotoxic effect at 0.05 mg/mL. In clin. situations, medical devices can release plasticizers, which can come into contact with patients. In vivo, the plasticizers are quickly transformed into primary metabolites. It is therefore important to measure the effects of both the plasticizers and their corresponding metabolites. Standard first-line cytotoxicity assays should be performed to ensure biocompatibility. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Reference of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to fibroblast l929 cell line dehp alternative plasticizer metabolite cytotoxicity, cytotoxicity, dehp-alternative plasticizers, metabolite synthesis, phthalates, plasticizers and other aspects.Reference of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2021, Kassotis, Christopher D.; Hoffman, Kate; Phillips, Allison L.; Zhang, Sharon; Cooper, Ellen M.; Webster, Thomas F.; Stapleton, Heather M. published an article.Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Characterization of adipogenic, PPARγ, and TRβ activities in house dust extracts and their associations with organic contaminants. And the article contained the following:

In this study, we sought to expand our previous research on associations between bioactivities in dust and associated organic contaminants. Dust samples were collected from central NC homes (n = 188), solvent extracted, and split into two fractions, one for anal. using three different bioassays (nuclear receptor activation/inhibition and adipocyte development) and one for mass spectrometry (targeted measurement of 124 organic contaminants, including flame retardants, polychlorinated biphenyls, perfluoroalkyl substances, pesticides, phthalates, and polycyclic aromatic hydrocarbons). Approx. 80% of dust extracts exhibited significant adipogenic activity at concentrations that are comparable to estimated exposure for children and adults (e.g. ∼20μg/well dust) via either triglyceride accumulation (65%) and/or pre-adipocyte proliferation (50%). Approx. 76% of samples antagonized thyroid receptor beta (TRβ), and 21% activated peroxisome proliferator activated receptor gamma (PPARγ). Triglyceride accumulation was significantly correlated with TRβ antagonism. Sixty-five contaminants were detected in at least 75% of samples; of these, 26 were correlated with adipogenic activity and ten with TRβ antagonism. Regression models were used to evaluate associations of individual contaminants with adipogenic and TRβ bioactivities, and many individual contaminants were significantly associated An exploratory g-computation model was used to evaluate the effect of mixtures Contaminant mixtures were pos. associated with triglyceride accumulation, and the magnitude of effect was larger than for any individually measured chem. For each quartile increase in mixture exposure, triglyceride accumulation increased by 212% (RR = 3.12 and 95% confidence interval: 1.58, 6.17). These results suggest that complex mixtures of chems. present in house dust may induce adipogenic activity in vitro at environmental concentrations and warrants further research. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to house dust endocrine disrupting chem bioactivity bioassays mass spectrometry, adipogenesis, endocrine disrupting chemicals, house dust, metabolic disruption, obesity, obesogen and other aspects.Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2019, Shang, Jijun; Corriveau, Jeanne; Champoux-Jenane, Alexandre; Gagnon, Julie; Moss, Emmanuel; Dumas, Pierre; Gaudreau, Eric; Chevrier, Jonathan; Chalifour, Lorraine E. published an article.Electric Literature of 3319-31-1 The title of the article was Recovery from a myocardial infarction is impaired in male C57bl/6N mice acutely exposed to the bisphenols and phthalates that escape from medical devices used in cardiac surgery. And the article contained the following:

Bisphenols and phthalates leach from medical devices, and this exposure is likely to increase in postcardiac surgery patients. Previous studies suggest that such chem. exposure may impact recovery and wound healing, yet the direct effects of bisphenols and phthalates are unknown in this context. To study the direct effect of clin. based chem. exposures, we measured the metabolites representative of 6 bisphenols and 10 phthalates in men before and after cardiac surgery and then replicated this exposure in a mouse model of cardiac surgery and assessed survival, cardiac function and inflammation. Bisphenol A (BPA), di-Et hexyl phthalate (DEHP), butylbenzyl phthalate, di-isodecyl phthalate, and di-Bu phthalate metabolites were increased after surgery. DEHP exposure predominated, was pos. correlated with duration on the cardiopulmonary bypass machine and exceeded its tolerable daily intake limit by 37-fold. In vivo, C57bl/6N male mice treated with BPA+phthalates during recovery from surgery-induced myocardial infarction had reduced survival, greater cardiac dilation, reduced cardiac function and increased infiltration of neutrophils, monocytes and macrophages suggesting impaired recovery. Of interest, genetic ablation or estrogen receptor beta (ERβ) antagonism did not improve recovery and replacement of DEHP with tri-octyl trimellitate or removal of BPA from the mixture did not ameliorate these effects. To examine the direct effects on inflammation, treatment of human THP-1 macrophages with BPA and phthalates induced a dysfunctional proinflammatory macrophage phenotype with increased expression of M1-type macrophage polarization markers and MMP9 secretion, yet reduced phagocytic activity. These results suggest that chems. escape from medical devices and may impair patient recovery. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Electric Literature of 3319-31-1

The Article related to myocardial infarction heart surgery medical device bisphenol phthalate inflammation, bisphenol a, estrogen receptor, macrophage, medical devices, myocardial infarction, phthalates and other aspects.Electric Literature of 3319-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On September 1, 2017, Hoellerer, Christine; Mueller, Johannes; Goeen, Thomas; Eckert, Elisabeth published an article.Safety of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Isomeric separation and quantitation of di-(2-ethylhexyl) trimellitates and mono-(2-ethylhexyl) trimellitates in blood by LC-MS/MS. And the article contained the following:

A new and fast HPLC-method for the simultaneous determination of tri-(2-ethylhexyl) trimellitate (TOTM or TEHTM), its diesters 2,4-di-(2-ethylhexyl) trimellitate (2,4-DEHTM), 1,4-di-(2-ethylhexyl) trimellitate (1,4-DEHTM), 1,2-di-(2-ethylhexyl) trimellitate (1,2-DEHTM) and monoesters 1-mono-(2-ethylhexyl) trimellitate (1-MEHTM), 2-mono-(2-ethylhexyl) trimellitate (2-MEHTM) and 4-mono-(2-ethylhexyl) trimellitate (4-MEHTM) together with di-(2-ethylhexyl) phthalate (DEHP) and its primary metabolite mono-(2-ethylhexyl) phthalate (MEHP) in blood was developed and validated. The analytes are extracted from blood using liquid-liquid extraction and are chromatog. separated by reversed-phase HPLC using core shell material. Quant. assessment was performed by ESI-tandem mass spectrometry in neg. ionization mode using stable isotope dilution In less than 30 min six postulated primary metabolites of TOTM along with the DEHP metabolite MEHP can be selectively and sensitively quantified. Addnl., the method enables the determination of the parent plasticizers TOTM and DEHP. The detection limits in blood were found to range between 0.7-5.5 μg/L for all TOTM analytes. Precision and repeatability of the method were proven by relative standard deviations between 0.9% and 8.7%. TOTM, an alternative plasticizer to DEHP, is already increasingly used for medical devices. Nevertheless, data about the human metabolism of TOTM are still limited. The presented method is the first one enabling the simultaneous determination of the parent plasticizers TOTM and DEHP together with their primary degradation products (DEHTM, MEHTM, MEHP) and can thus be applied manifold including the investigation of the human metabolism of TOTM. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Safety of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to monoethylhexyl diethylhexyl trimellitate quantitation blood lc ms, biomonitoring, core shell material, di-(2-ethylhexyl) phthalate, human metabolites, tri-(2-ethylhexyl) trimellitate and other aspects.Safety of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2021, Poma, Giulia; Fujii, Yukiko; Lievens, Siebe; Bombeke, Jasper; Gao, Beibei; Jeong, Yunsun; McGrath, Thomas Jacob; Covaci, Adrian published an article.HPLC of Formula: 3319-31-1 The title of the article was Occurrence, patterns, and sources of hazardous organic chemicals in edible insects and insect-based food from the Japanese market. And the article contained the following:

Due to the growth of the world′s population, edible insects have been considered a valuable alternative food source for humans. Japan has a long-lasting traditional culture of eating wild insects, a practice that has recently evolved towards farming and selling reared edible insects. In this study, we investigated the contamination loads, profiles, and possible sources of organophosphorus flame retardants (PFRs), plasticizers, and selected persistent organic pollutants (POPs) in insect foods available on the Japanese market. Medians of selected POPs in the dataset were up to 1.3 ng/g lw, while medians of PFRs and plasticizers were 12 and 486 ng/g ww, resp. CB-153, p,p′-DDE, BDE-47, tris(1-chloro-2-propyl)-phosphate (TCIPP), and bis(2-ethylhexyl)-phthalate (DEHP) were the dominant compounds in the analyzed samples, a pattern comparable to previous investigations on organic chems. in edible insects. Our overall results suggest that POPs were likely accumulated by the insects during rearing or from the wild environment, while PFRs and plasticizers derived from post-harvesting industrial handling and seasoning. Differences in pollution patterns and the absence of correlations between PFR and plasticizer loads in insects and in food packaging suggest that the transfer of contaminants from food contact materials is not a main source of contamination. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).HPLC of Formula: 3319-31-1

The Article related to edible insect hazardous organic chem food japanese market, entomophagy, food contact materials, insect food, organophosphorus flame retardants, persistent organic pollutants, plasticizers and other aspects.HPLC of Formula: 3319-31-1

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 30, 2022, Uribe-Echeverria, Teresa; Beiras, Ricardo published an article.Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Acute toxicity of bioplastic leachates to Paracentrotus lividus sea urchin larvae. And the article contained the following:

In an attempt to ensure that bioplastics, progressively replacing petrochem.-derived plastics, do not release any harmful compound to the environment, the study assessed the toxic effects of three innovative bioplastic products: polyhydroxybutyrate resin (PHB), polylactic acid cups (PLA) and a polylactic acid/polyhydroxyalkanoate 3D printing filament (PLA/PHA), together with a synthetic polyvinyl chloride (PVC) toy in Paracentrotus lividus sea urchin larvae. PVC toy was the most toxic material, likely due to the added plasticizers; remarkably, even if PHB is conceived as a nontoxic polymer, it showed a slight toxicity and Gas Chromatog.-Mass Spectometry anal. (GC-MS) revealed the presence of a wide range of additives. Conversely, PLA cups and PLA/PHA filament were innocuous for the larvae, a pos. outcome for these renewable solutions Proven that additives are also used in some bioplastic formulations, they should be carefully addressed to ensure that they are as safe as regarded. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to paracentrotus lividus acute toxicity bioplastic leachates, additives, bioplastic, ecotoxicology, larval bioassay, microplastic, paracentrotus lividus, polyhydroxybutyrate, polylactic acid and other aspects.Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 30, 2021, Choi, Sun-Il; Kwon, Hee-Yeon; Han, Xionggao; Men, Xiao; Choi, Ye-Eun; Jang, Gill-Woong; Park, Keun-Tae; Han, Jongkwon; Lee, Ok-Hwan published an article.Formula: C33H54O6 The title of the article was Environmental obesogens (bisphenols, phthalates and parabens) and their impacts on adipogenic transcription factors in the absence of dexamethasone in 3T3-L1 cells. And the article contained the following:

Endocrine-disrupting chems. (EDCs) are exogenous compounds that are capable of blocking or mimicking the action of bioidentical hormones. Obesogenic EDCs, commonly called obesogens, play an important role in adipogenesis. This study was carried out to determine the effects of select obesogens and their alternatives on adipogenesis in 3T3-L1 cells under dexamethasone (DEX)-free conditions. Preadipocytes were treated with a cocktail of 3-isobutyl-1-methylxanthine (IBMX) and insulin to which an obesogen (viz., bisphenol A (BPA) or its analogs BPS and BPF; dioctyl terephthalate; tris (2-ethylhexyl) trimellitate; or various parabens) had been added. A mixture containing IBMX, insulin, and DEX, which constitute the typical hormonal cocktail required for adipocyte differentiation, was used as the control against which the other groups were measured. The obesogens and the PBA analogs all had evident adipogenic effects under DEX-free conditions, as was determined by estimating the lipid accumulation levels in the cells using Oil Red O staining. Furthermore, the expression of adipogenic transcription factors (CCAAT/enhancer-binding protein-alpha, peroxisome proliferator-activated receptor-gamma, and adipocyte protein 2) was induced by 20μM of BPA, BPS, or BPF at both the mRNA and protein levels, as determined through reverse transcription-polymerase chain reaction and western blot assays. Taken together, the results reveal that adipocyte differentiation can be induced by obesogens and their alternatives in the absence of DEX. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Formula: C33H54O6

The Article related to endocrine disrupting chem obesogen bisphenol phthalate paraben, lipid metabolism disorder, bisphenols, endocrine disrupting chemicals, lipid metabolism disorders, obesogen, parabens, phthalates and other aspects.Formula: C33H54O6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics