Category: 3319-31-1

On December 1, 2020, Kassotis, Christopher D.; Herkert, Nicholas J.; Hammel, Stephanie C.; Hoffman, Kate; Xia, Qianyi; Kullman, Seth W.; Sosa, Julie Ann; Stapleton, Heather M. published an article.Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Thyroid Receptor Antagonism of Chemicals Extracted from Personal Silicone Wristbands within a Papillary Thyroid Cancer Pilot Study. And the article contained the following:

Research suggests that thyroid cancer incidence rates are increasing, and environmental exposures have been postulated to be playing a role. To explore this possibility, we conducted a pilot study to investigate the thyroid disrupting bioactivity of chem. mixtures isolated from personal silicone wristband samplers within a thyroid cancer cohort. Specifically, we evaluated TRβ antagonism of chem. mixtures extracted from wristbands (n = 72) worn by adults in central North Carolina participating in a case-control study on papillary thyroid cancer. Sections of wristbands were solvent-extracted and analyzed via mass spectrometry to quantify a suite of semivolatile chems. A second extract from each wristband was used in a bioassay to quantify TRβ antagonism in human embryonic kidney cells (HEK293/17) at concentrations ranging from 0.1 to 10% of the original extract (by volume). Approx. 70% of the sample extracts tested at a 1% extract concentration exhibited significant TRβ antagonism, with a mean of 30% and a range of 0-100%. Inhibited cell viability was noted in >20% of samples that were tested at 5 and 10% concentrations Antagonism was pos. associated with wristband concentrations of several phthalates, organophosphate esters, and brominated flame retardants. These results suggest that personal passive samplers may be useful in evaluating the bioactivities of mixtures that people contact on a daily basis. We also report tentative associations between thyroid receptor antagonism, chem. concentrations, and papillary thyroid cancer case status. Future research utilizing larger sample sizes, prospective data collection, and measurement of serum thyroid hormone levels (which were not possible in this study) should be utilized to more comprehensively evaluate these associations The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to thyroid receptor antagonist silicone wristband papillary thyroid cancer, Placeholder for records without volume info and other aspects.Application In Synthesis of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

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Ester – an overview | ScienceDirect Topics

On November 30, 2019, Lineira del Rio, Jose M.; Guimarey, Maria J. G.; Comunas, Maria J. P.; Fernandez, Josefa published an article.Electric Literature of 3319-31-1 The title of the article was High pressure viscosity behaviour of tris(2-ethylhexyl) trimellitate up to 150 MPa. And the article contained the following:

This article presents a study on the viscous behavior at high pressure of a synthetic oil, tris(2-ethylhexyl) trimellitate. This fluid is being recommended as potential industrial reference material for high viscosity-high pressure measurements. Here we report new exptl. viscosity values for TOTM at temperatures from 278.15 K to 373.15 K and at pressures to 150 MPa with a maximum viscosity of 2570 mPa s. The measurements have been performed using a high pressure falling-body apparatus and a Couette rotational viscometer. The exptl. values obtained in this work are included in the database of a multinational project used recently to develop a reference correlation for TOTM. The universal viscosity-pressure coefficient of this fluid has been evaluated and compared with other oils, finding that it is close to the literature values of mineral oils. Moreover, we perform an anal. of the dependency of viscosity on pressure and temperature based on the d. scaling concept. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Electric Literature of 3319-31-1

The Article related to trisethylhexyl trimellitate pressure viscosity temperature density scaling method, Placeholder for records without volume info and other aspects.Electric Literature of 3319-31-1

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On June 30, 2022, Harmon, Patrick; Otter, Rainer published an article.Formula: C33H54O6 The title of the article was A review of common non-ortho-phthalate plasticizers for use in food contact materials. And the article contained the following:

A review. Several non-ortho phthalate plasticizers, including ATBC, DEHA, DINCH, DOTP, and ESBO, are currently used in flexible PVC applications for food packaging and processing. The aim of this review is to summarize the available toxicity, migration, and human biomonitoring data. Available assessments from US CPSC, EFSA, other governmental and non-governmental organizations, and published toxicol. studies were used to show that these plasticizers are generally well-studied and demonstrate low toxicity with a focus on potential carcinogenicity, reproductive, developmental, and endocrine related adverse effects as well as biodegradation, aquatic toxicity, and bioaccumulation. Seven other plasticizers, 2EHESBO, ASE, COMGHA, DBT, DEHCH, PETV, and TOTM, have at least some recent but limited food contact clearances; assessments from CPSC, EFSA, and robust summaries in the REACH dossiers were reviewed for these products. Data gaps were found for some of these; however, there were no concerns raised by the existing data, and they for now have limited use in food contact applications. Migration of ASE, COMGHA, DINCH, DOTP, DEHCH, and TOTM in simulants for aqueous and low alc. foods ranged from <0.02 to 0.165 mg/kg, which showed they are below established migration limits and well-suited for these applications. Human biomonitoring data are available for DINCH, DOTP, DEHA, DINA, and TOTM, and are essential for determining exposure from all uses. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Formula: C33H54O6

The Article related to review nonorthophthalate plasticizer food contact material, exposure, migration, phthalates, plasticizers, toxicity, Placeholder for records without volume info and other aspects.Formula: C33H54O6

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Sheikh, Ishfaq A.; Yasir, Muhammad; Abu-Elmagd, Muhammad; Dar, Tanveer A.; Abuzenadah, Adel M.; Damanhouri, Ghazi A.; Al-Qahtani, Mohammed; Beg, Mohd. A. published an article in 2016, the title of the article was Human sex hormone-binding globulin as a potential target of alternate plasticizers: an in silico study.Computed Properties of 3319-31-1 And the article contains the following content:

Current information regarding the safety and potential adverse effects of alternate plasticizers is limited and recent studies have found alternate plasticizers to display similar characteristics to those observed in phthalate plasticizers. This study was undertaken to evaluate and predict the potential endocrine disrupting activity of the three most commonly used alternate plasticizers: di(2-ethylhexyl)terephthalate (DEHT), tris(2-ethylhexyl) trimellitate (TOTM), and diisononyl hexahydrophthalate (DINCH) against human sex hormone-binding globulin (SHBG) using in silico approaches. Materials and methods: The crystal structure of human SHBG (Id: 1D2S) was retrieved from Protein Data Bank. Results: Induced Fit Docking of three alternate plasticizer compounds indicated that each of the three compounds fitted well into the steroid binding pocket of SHBG. Docking displays showed interactions of alternate plasticizers with 25-30 amino-acid residues of SHBG; 18-20 amino residues overlapped between the natural ligand, DHT, and the three compounds (commonality of 82-91 %). The hydrogen-bonding interaction of the amino-acid residue, Asn-82, of SHBG was also present in displays of DHT and all the three alternate phthalates. Conclusion: Our results suggested that the three alternate plasticizers have potential to engage the important interacting residues of SHBG and thus interfere in its steroid homeostatic function. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Computed Properties of 3319-31-1

The Article related to sex hormone binding globulin mol docking plasticizer, deht, dinch, docking, endocrine disruption, sex hormone-binding globulin, totm, Placeholder for records without volume info and other aspects.Computed Properties of 3319-31-1

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On May 30, 2021, Hu, Yajing; Du, Zhenxia; Sun, Xuechun; Ma, Xin; Song, Jingdan; Sui, Haixia; Debrah, Augustine Atta published an article.Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Non-targeted analysis and risk assessment of non-volatile compounds in polyamide food contact materials. And the article contained the following:

Small mols. in food contact materials may migrate into food during their contact. To extensively analyze the migrants, non-targeted screening is needed to detect the migrants. The migrants detection is difficult because of the complexity and the trace amount of the migrants. In this work, the dissolution precipitation method was used to extract small mols. in Polyamide (PA) kitchenware. The extract solutions were screened by ultra-performance liquid chromatog.-quadrupole time-of-flight-mass spectrometry (UPLC-QTOF-MS) for non-targeted anal. and 64 different small mols. in materials were identified through the screening of a self-built database. Then, migration tests were performed to analyze migrants in food simulants. It suggests that the abundance of PA oligomers was the highest in migrants. The risk assessment of migrants revealed that the exposure of most migrants was at a safer level unlike the exposure of PA oligomers that exceeded their threshold of toxicol. concern (TTC). The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to polyamide food contact dissolution precipitation, migrants, pa food contact materials, ttc, uplc-qtof-ms, Placeholder for records without volume info and other aspects.Recommanded Product: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

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Ester – an overview | ScienceDirect Topics

On May 10, 2018, Wakeham, William A.; Assael, Marc J.; Avelino, Helena M. N. T.; Bair, Scott; Baled, Hseen O.; Bamgbade, Babatunde A.; Bazile, Jean-Patrick; Caetano, Fernando J. P.; Comunas, Maria J. P.; Daridon, Jean-Luc; Diogo, Joao C. F.; Enick, Robert M.; Fareleira, Joao M. N. A.; Fernandez, Josefa; Oliveira, M. Conceicao; Santos, Tania V. M.; Tsolakidou, Chrysi M. published an article.Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Correction to “In Pursuit of a High-Temperature, High-Pressure, High-Viscosity Standard: The Case of Tris(2-ethylhexyl) Trimellitate” [Erratum to document cited in CA167:314233]. And the article contained the following:

In the original publication, there are errors in equation 9 and table 5; the correction is provided here. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to ethylhexyl trimellitate reference compound viscosity elevated temperature pressure industry, erratum, Placeholder for records without volume info and other aspects.Quality Control of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

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On July 31, 2022, Kim, Donghyun; Park, Ji Young; Lee, Dong Hyun; Lim, Jae-Eun; Moon, Hyo-Bang; Kim, Sungkyoon; Lee, Kiyoung published an article.Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Simultaneous assessment of organophosphate flame retardants, plasticizers, trace metals, and house dust mite allergens in settled house dust. And the article contained the following:

Settled house dust (SHD) is a reservoir for various contaminants, including endocrine-disrupting chems. (EDCs), trace metals, and house dust mite allergens. This study aimed to characterize various chem. and biol. contaminants in SHD and identify determinants governing the indoor contaminants. In total, 106 SHD samples were collected from 106 houses in Seoul and Gyeonggi Province, Korea, in 2021. Bedding dust samples were collected from 30 of these 106 houses. All participants completed a questionnaire comprised of housing and lifestyle-related factors. The samples were analyzed for 18 organophosphate flame retardants (OPFRs), 16 phthalates, five alternative plasticizers (APs), seven trace metals, and two house dust mite allergens (Dermatophagoides farinae type 1 [Der f1] and Dermatophagoides pteronyssinus type 1 [Der p1]). A multiple regression anal. was conducted to identify the determinants governing the concentrations and profiles of various contaminants. OPFRs, phthalates, APs, and trace metals were detected in all SHD samples, indicating ubiquitous contamination in indoor environments. Among the three EDC groups, APs were detected at the highest concentrations (geometric mean [GM] (geometric standard deviation, [GSD]): 1452 (1.6)μg/g in total), followed by phthalates (GM (GSD): 676 (1.4) μg/g in total) and OPFRs (GM (GSD): 10 (1.4) μg/g in total). Der f1 was detected in all bedding dust samples with significantly higher levels than Der p1 (GM (GSD): 0.1 (1.8) μg/g vs. 1.4 x 10-3 (2.3) μg/g). The concentrations of OPFRs, plasticizers, and trace metals in SHD were significantly associated with the type and number of electronic appliances and combustion activities. Der f1 was significantly associated with the number of occupants and water penetration. Ventilation, vacuum cleaning, and wet cleaning or dry mopping significantly reduced the levels of most contaminants in SHD. As residents are persistently exposed to a wide array of pollutants, comprehensive and adequate measures are required to prevent potential exposures. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to organophosphate flame retardant phenol plasticizer mite allergens house dust, opfr, alternative, house dust mite allergens, plasticizer, settled house dust, Placeholder for records without volume info and other aspects.Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

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Ester – an overview | ScienceDirect Topics

Bernard, Lise; Eljezi, Teuta; Clauson, Helene; Lambert, Celine; Bouattour, Yassine; Chennell, Philip; Pereira, Bruno; Sautou, Valerie; ARMED Study Group published an article in 2018, the title of the article was Effects of flow rate on the migration of different plasticizers from PVC infusion medical devices.Computed Properties of 3319-31-1 And the article contains the following content:

Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clin. practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact with the patients. The migrability of the plasticizers is dependent of several clin. parameters such as temperature, contact time, nature of the simulant, etc. . . However, no data is available about the influence of the flow rate at which drug solutions are administrated. In this study, we evaluated the impact of different flow rates on the release of the different plasticizers during an infusion procedure in order to assess if they could expose the patients to more toxic amounts of plasticizers. Migration assays with different PVC infusion sets and extension lines were performed with different flow rates that are used in clin. practice during 1h, 2h, 4h, 8h and 24h, using a lipophilic drug simulant. From a clin. point of view, the results showed that, regardless of the plasticizer, the faster the flow rate, the higher the infused volume and the higher the quantities of plasticizers released, both from infusion sets and extension lines, leading to higher patient exposure. However, phys., there was no significant difference of the migration kinetics linked to the flow rate for a same medical device, reflecting complex interactions between the PVC matrix and the simulant. The migration was especially dependent on the nature and the composition of the medical device. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Computed Properties of 3319-31-1

The Article related to polyvinylchloride flow rate plasticizer migration infusion medical device, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Computed Properties of 3319-31-1

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On January 31, 2021, Murawski, Aline; Schmied-Tobies, Maria I. H.; Rucic, Enrico; Schmidtkunz, Christoph; Kuepper, Katja; Leng, Gabriele; Eckert, Elisabeth; Kuhlmann, Laura; Goeen, Thomas; Daniels, Anja; Schwedler, Gerda; Kolossa-Gehring, Marike published an article.Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate The title of the article was Metabolites of 4-methylbenzylidene camphor (4-MBC), butylated hydroxytoluene (BHT), and tris(2-ethylhexyl) trimellitate (TOTM) in urine of children and adolescents in Germany – human biomonitoring results of the German Environmental Survey GerES V (2014-2017). And the article contained the following:

The UV filter 4-methylbenzylidene camphor (4-MBC), used in cosmetics, the antioxidant butylated hydroxytoluene (BHT), used inter alia as a food additive and in cosmetics, and the plasticizer tris(2-ethylhexyl) trimellitate (TOTM), used mainly in medical devices as substitute for di-(2-ethylhexyl) phthalate (DEHP), are suspected to have endocrine disrupting effects. Human biomonitoring methods that allow for assessing the internal exposure of the general population to these substances were recently developed in a German cooperation to enhance the use of human biomonitoring. First-morning void urine samples from 3- to 17-yr-old children and adolescents living in Germany were analyzed for metabolites of 4-MBC (N = 447), BHT (N = 2091), and TOTM (N = 431) in the population-representative German Environmental Survey on Children and Adolescents 2014-2017 (GerES V). 4-MBC metabolites were found in quantifiable amounts only in single cases and exposure levels remained well below health-based guidance values. In contrast, ubiquitous exposure to BHT became evident with a geometric mean (GM) urinary concentration of the metabolite BHT acid of 2.346μg/L (1.989μg/gcreatinine) and a maximum concentration of 248μg/L (269μg/gcrea). The highest GM concentration was found in young children aged 3-5 years, yet no specific sources of exposure could be identified. Also, TOTM metabolites were found in quantifiable amounts only in very few samples. None of these findings could be related to previous hospital treatment or exposure via house dust. The presented results will be the basis to derive reference values for exposure of children and adolescents in Germany to BHT and will facilitate to identify changing exposure levels in the general population. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

The Article related to pollutant urine child adolescent germany, antioxidant, endocrine disruptor, exposure, plasticizer, tehtm, uv filter, Air Pollution and Industrial Hygiene: Analysis and other aspects.Name: Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate

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On July 31, 2018, Muench, Frank; Hoellerer, Christine; Klapproth, Andre; Eckert, Elisabeth; Rueffer, Andre; Cesnjevar, Robert; Goeen, Thomas published an article.Product Details of 3319-31-1 The title of the article was Effect of phospholipid coating on the migration of plasticizers from PVC tubes. And the article contained the following:

Plasticizers in polyvinyl chloride (PVC) are not covalently bound to the polymer and can thus migrate into the contact medium. The presented study investigated the potential effects of phospholipid-lining as anti-coagulation coating (ACC) on the migration rate of plasticizers from PVC tubing into blood. For the in-vitro study, five different groups of tubing sets in six replicates were perfused with sheep blood (Group A: PVC plasticized with di-(2-ethylhexyl) phthalate (DEHP) without ACC, Group B: DEHP-plasticized PVC with ACC, Group C: PVC plasticized with tri-(2-ethylhexyl) trimellitate (TOTM) without ACC, Group D: TOTM-plasticized PVC with ACC, Group E (control group): polyolefin material with ACC but without plasticizers). Both the levels of the unchanged plasticizers in blood and the concentration levels of their primary degradation products were assessed. For DEHP, the primary metabolite MEHP (mono-(2-ethylhexyl) phthalate) was determined The isomers of MEHTM (mono-(2-ethylhexyl) trimellitate) and DEHTM (di-(2-ethylhexyl) trimellitate), resp., were investigated as primary metabolites of TOTM. The calculated DEHP equivalent (sum of determined levels of DEHP and MEHP) after 24 h of perfusion displayed a tendency towards lower levels in the tubing sets without ACC (Group A (201 ± 56.4μmol/L)) compared to the tubing sets with ACC (Group B (253 ± 369μmol/L)). Significantly different DEHP equivalent between Group A and Group B were found after a perfusion time of 6 h and 10 h, resp. A similar effect was observed for the TOTM-containing tubing sets. However, the absolute plasticizer migration rate of TOTM (TOTM equivalent) after 24 h of perfusion was found to be significantly lower compared to that of DEHP (with a factor of over 200). The results indicate that phospholipid coating (ACC) rather enhances the migration of plasticizers and of their primary degradation products from PVC tubing into streaming blood. The enhancement effect was found to be slightly greater for TOTM, but as TOTM migrates in significantly lower levels than DEHP in all exptl. settings, TOTM is confirmed to be a recommendable alternative plasticizer to DEHP in medical devices. The experimental process involved the reaction of Tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate(cas: 3319-31-1).Product Details of 3319-31-1

The Article related to blood plasticizer anticoagulation phospholipid polyvinyl chloride tube, blood management, dehp, hemocompatibility, medical device, patient safety, totm, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Product Details of 3319-31-1

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