Category: 33155-58-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 33155-58-7, name is tert-Butyl 2-(4-Bromophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., category: esters-buliding-blocks

To a stirring solution of 2-(5-chlorothiophen-2-yl)-4-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine (1 eq.)in toluene (1.5 ml) was added Na01Bu (1.6 eq.), tert-butyl 2-(4-bromophenyl)acetate (1.5eq.) and BINAP (0.04 eq.). The resulting reaction mixture was degassed with argon for a period of 10 min. and Pd2dba3 (0.02eq.) was added and the mixture was degassed again. The reaction mixture was heated at 100C for16 h. At completion, the reaction mixture was concentrated and poured in DMF (2 mi).The inorganics were filtered and the residue was purified by prep-HPLC using aqueous ammonia method to give tert- butyl 2-(4-(2-(5-chlorothiophen-2-yl)-4-methyi-5H-pyrrolo[2,3-d]pyrimidin-7(6H)-yl)phenyl)acetate which was directly used for the next step. ).

According to the analysis of related databases, 33155-58-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GRUeNENTHAL GMBH; JAKOB, Florian; KONETZKI, Ingo; CRAAN, Tobias; NARDI, Antonio; HESSLINGER, Christian; WO2015/18534; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 33155-58-7, A common heterocyclic compound, 33155-58-7, name is tert-Butyl 2-(4-Bromophenyl)acetate, molecular formula is C12H15BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To an N?-purged flask containing the title compound from the previous step (1.55 g, 5.55 mmol), were added PdCl2(PPh3)2 (584 mg, 0.83 mmol), w-BuOH (30 mL), and DIEA (5.00 mL, 27.8 mmol). The mixture was placed under an atmosphere of carbon monoxide and stirred vigorously at 110 0C. After 1 h, the reaction mixture was allowed to cool to room temperature, and was concentrated in vacuo. Purification by silica gel chromatography (0 to 100% EtOAc in hexanes) provided the title compound: LCMS (ESI): m/z 237.3 [M – tBu]+; 1H NMR (500 MHz, CDCl3): delta 7.99 (d, J = 8.0 Hz, 2 H)5 7.34 (d, J = 8.0 Hz, 2 H), 4.32 (t, J = 6.5 Hz, 2 H), 1.77-1.72 (m, 2 H), 1.51-1.45 (m, 2 H), 1.43 (s, 9 H), 0.98 (t, J = 8.0 Hz, 3 H).

The synthetic route of 33155-58-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2007/136577; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics