Category: 329-59-9

Safety of Methyl 4-fluoro-3-nitrobenzoateIn 2017 ,《Structural insight into allosteric modulation of protease-activated receptor 2》 appeared in Nature (London, United Kingdom). The author of the article were Cheng, Robert K. Y.; Fiez-Vandal, Cedric; Schlenker, Oliver; Edman, Karl; Aggeler, Birte; Brown, Dean G.; Brown, Giles A.; Cooke, Robert M.; Dumelin, Christoph E.; Dore, Andrew S.; Geschwindner, Stefan; Grebner, Christoph; Hermansson, Nils-Olov; Jazayeri, Ali; Johansson, Patrik; Leong, Louis; Prihandoko, Rudi; Rappas, Mathieu; Soutter, Holly; Snijder, Arjan; Sundstrom, Linda; Tehan, Benjamin; Thornton, Peter; Troast, Dawn; Wiggin, Giselle; Zhukov, Andrei; Marshall, Fiona H.; Dekker, Niek. The article conveys some information:

Protease-activated receptors (PARs) are a family of G-protein-coupled receptors (GPCRs) that are irreversibly activated by proteolytic cleavage of the N-terminus, which unmasks a tethered peptide ligand that binds and activates the transmembrane receptor domain, eliciting a cellular cascade in response to inflammatory signals and other stimuli. PARs are implicated in a wide range of diseases, such as cancer and inflammation. PARs have been the subject of major pharmaceutical research efforts, but the discovery of small-mol. antagonists that effectively bind them has proved challenging. The only marketed drug targeting a PAR is vorapaxar, a selective antagonist of PAR1 used to prevent thrombosis. The structure of PAR1 in complex with vorapaxar has been reported previously. Despite sequence homol. across the PAR isoforms, discovery of PAR2 antagonists has been less successful, although GB88 has been described as a weak antagonist. Here, we report crystal structures of PAR2 in complex with two distinct antagonists and a blocking antibody. The antagonist AZ8838 binds in a fully occluded pocket near the extracellular surface. Functional and binding studies reveal that AZ8838 exhibits slow binding kinetics, which is an attractive feature for a PAR2 antagonist competing against a tethered ligand. Antagonist AZ3451 binds to a remote allosteric site outside the helical bundle. We propose that antagonist binding prevents structural rearrangements required for receptor activation and signalling. We also show that a blocking antibody antigen-binding fragment binds to the extracellular surface of PAR2, preventing access of the tethered ligand to the peptide-binding site. These structures provide a basis for the development of selective PAR2 antagonists for a range of therapeutic uses. After reading the article, we found that the author used Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Safety of Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Safety of Methyl 4-fluoro-3-nitrobenzoate

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Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateIn 2004 ,《Traceless Solid-Phase Synthesis of Substituted Benzimidazolones》 was published in Journal of Combinatorial Chemistry. The article was written by Wang, Chih-Chung; Li, Wen-Ren. The article contains the following contents:

A new approach to substituted benzimidazolones is described. The key step of the sequence involved the introduction of one of the nitrogens by nucleophilic addition of a carbamate to an o-fluoronitrobenzene. Spontaneous cyclization and detachment of the benzimidazolones from the resin occurred in high yields under reductive conditions on solid supports. To further expand the scale and incorporate a third element of diversity into the library of target mols., the benzimidazolones were treated with NaH and various alkyl halides in DMF to afford fully functionalized benzimidazolones. In the experimental materials used by the author, we found Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Sheng-Nan; Chen, Yu; Luo, Xiao-Dong; Li, Yi published their research in European Journal of Organic Chemistry in 2021. The article was titled 《Sustainable Cascades to Difluoroalkylated Polycyclic Imidazoles》.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate The article contains the following contents:

Herein a visible light promoted difluoroalkylated cascade of imidazoles and alkenes e.g., I to afford highly functionalized polycyclic imidazoles e.g., II was reported. This method features a direct radical cyclization of imidazoles with alkenes e.g., I using BrCF2R (R = C(O)OEt, N-cyclohexylcarbamoyl, (thiomorpholin-4-yl)carbonyl, etc.) as radical sources. The reaction conditions tolerate a wide range of substrate scope and afford the desired products e.g., II with up to 95% isolated yield under mild conditions. Radical-trapping and light-on/off experiments indicated a photocatalytic radical mechanism. In the experimental materials used by the author, we found Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2005,Vickerstaffe, Emma; Warrington, Brian H.; Ladlow, Mark; Ley, Steven V. published 《A Highly Automated, Polymer-Assisted Strategy for the Preparation of 2-Alkylthiobenzimidazoles and N,N’-Dialkylbenzimidazolin-2-ones》.Journal of Combinatorial Chemistry published the findings.Quality Control of Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:

A multistep, polymer-assisted solution phase strategy for the highly automated (auto-PASP) synthesis of 2-alkylthiobenzimidazole I [R1 = n-Pr, n-Bu, Me2CHCH2, PhCH2CH2, cyclopentyl, Et2CH, etc.; R2 = PhCH2, EtO2CCH2, 3,5-(MeO)2C6H3CH2, (5-methylisoxazol-3-yl)methyl, etc.] and N,N’-dialkylbenzimidazolin-2-one II libraries is presented. The approach incorporates in-line purification techniques to afford library products directly with high purities and is exemplified by the preparation of a 96-member 2-alkylthiobenzimidazole I library and a 72-member N,N’-dialkylbenzimidazolin-2-one II library.Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Quality Control of Methyl 4-fluoro-3-nitrobenzoate) was used in this study.

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Quality Control of Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2009,Ayral, Erwan; Gloanec, Philippe; Berge, Gilbert; de Nanteuil, Guillaume; Mennecier, Philippe; Rupin, Alain; Verbeuren, Tony J.; Fulcrand, Pierre; Martinez, Jean; Hernandez, Jean-Francois published 《Design, synthesis, and biological evaluation of 1,5-benzothiazepine-4-one derivatives targeting factor VIIa/tissue factor》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate The information in the text is summarized as follows:

The 1,5-benzothiazepine-4-one scaffold was earlier shown to provide efficient protease inhibitors. In this contribution, we describe its use in the design of factor VIIa/tissue factor inhibitors. A series containing a scaffold non-substituted on its aryl part led to compound I with an IC50 of 2.16 μM. Following mol. modeling studies of this compound, a second series was prepared, which necessitated the synthesis of protected 7- or 8-substituted 1,5-benzothiazepine-4-one derivatives The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateMethyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2015,Gampe, Dominique Mario; Kaufmann, Martin; Jakobi, Doerthe; Sachse, Torsten; Presselt, Martin; Beckert, Rainer; Goerls, Helmar published 《Stable and Easily Accessible Functional Dyes: Dihydrotetraazaanthracenes as Versatile Precursors for Higher Acenes》.Chemistry – A European Journal published the findings.Computed Properties of C8H6FNO4 The information in the text is summarized as follows:

A series of new dihydrotetraazaanthracenes and one new dihydrotetraazatetracene as substances for applications in organoelectronic devices and as suitable building blocks for higher azaacenes was synthesized. The condensation of aromatic diamines with dichlorodicyanopyrazine led to these tricyclic/tetracyclic compounds Syntheses of N-substituted phenylenediamines were developed to enable the introduction of multiple functional groups such as ester, amino, or nitro groups on the chromophoric system. Relationships between the structure and the spectroscopic properties could be derived from UV/Vis absorption and fluorescence spectroscopy, and by DFT and TD-DFT calculations of mol. and aggregate structures. The absorption spectra are dominated by π-π* transitions of the single mols., whereas aggregation needs to be taken into account to obtain reasonable agreement between theory and experiment in certain cases. Single-crystal x-ray analyses were carried out to examine the morphol. and solid packing effects. Finally, a dihydrotetraazaanthracene was used as a building-block to create a mesoionic octaazapentacene.Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Computed Properties of C8H6FNO4) was used in this study.

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Computed Properties of C8H6FNO4Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2017,Thikekar, Tushar Ulhas; Sun, Chung-Ming published 《Palladium-Catalyzed Regioselective Synthesis of 1,2-Fused Indole-Diazepines via [5+2] Annulation of o-Indoloanilines with Alkynes》.Advanced Synthesis & Catalysis published the findings.SDS of cas: 329-59-9 The information in the text is summarized as follows:

An efficient and regioselective palladium(II)-catalyzed [5+2] annulation of unprotected o-indoloanilines with internal alkynes under microwave irradiation has been explored. The diverse imine-containing 1,2-fused indole[1,7-a]diazepines, e.g., I are constructed in moderate to excellent yields. The mechanistic pathway shows pivalic acid and mol. oxygen to play crucial roles for the regeneration of highly active electrophilic palladium species in the catalytic cycle. The experimental part of the paper was very detailed, including the reaction process of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9SDS of cas: 329-59-9)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.SDS of cas: 329-59-9Methyl 4-fluoro-3-nitrobenzoate is used to prepare dimethyl 3-nitro-3′,4-oxydibenzoate by reacting with 3-hydroxy-benzoic acid methyl ester.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

The author of 《Oridonin derivatives as potential anticancer drug candidates triggering apoptosis through mitochondrial pathway in the liver cancer cells》 were Luo, Dongdong; Yi, Yujiao; Peng, Kai; Liu, Tangrong; Yang, Jiayu; Liu, Shan; Zhao, Wanzhou; Qu, Xianjun; Yu, Wengong; Gu, Yuchao; Wan, Shengbiao. And the article was published in European Journal of Medicinal Chemistry in 2019. Category: esters-buliding-blocks The author mentioned the following in the article:

The biol. function of the natural ent-kaurene diterpenoid isolated from genus Isodon, oridonin, has been intensively studied. However, its mechanism studies and clin. applications were hampered by its moderate biol. activities. In order to enlarge the applied range of oridonin and explore its mechanism of action, a series of derivatives were designed and synthesized based on the structure of oridonin. Some of the derivatives were significantly more potent than oridonin against four cancer cell lines. Especially, the most potent compound 20 markedly inhibited the proliferation of well differentiated HepG2 and poorly differentiated PLC/PRF/5 cells, with IC50 values as low as 1.36 μM and 0.78 μM resp., while the IC50 values of oridonin are 8.12 μM and 7.41 μM. We found that compound 20 inhibited liver cancer cell proliferation via arresting cell cycle at G1 phase. Moreover, it induced liver cancer cell apoptosis by decreasing the mitochondrial membrane potential, increasing intracellular reactive oxygen species level and inducing the expression of apoptosis-related proteins. Furthermore, compound 20 significantly inhibited growth of PLC/PRF/5 xenograft tumors in nude mice and had no observable toxic effect. Altogether, these results indicated that compound 20 is a promising lead for liver cancer therapeutics. The experimental process involved the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Category: esters-buliding-blocks)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《3D-Printed Polypropylene Continuous-Flow Column Reactors: Exploration of Reactor Utility in SNAr Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles》 was written by Rao, Zenobia X.; Patel, Bhaven; Monaco, Alessandra; Cao, Zi Jing; Barniol-Xicota, Marta; Pichon, Enora; Ladlow, Mark; Hilton, Stephen T.. Recommanded Product: Methyl 4-fluoro-3-nitrobenzoateThis research focused onthree dimensional printed polypropylene continuous flow reactor; bicyclic tetracyclic heterocycle preparation. The article conveys some information:

3D printing has the potential to transform the way in which chem. reactions are carried out due to its low-cost, ease-of-use as a technol. and its capacity to expedite the development of iteratively enhanced prototypes. In this present study, we developed a novel, low-cost polypropylene (PP) column reactor that was incorporated into an existing continuous-flow reactor for the synthesis of heterocycles. The utility and solvent resistance of the printed devices were explored in SNAr reactions to produce substituted aniline derivatives and in the synthesis of bicyclic and tetracyclic heterocycles. Using this approach, a range of heterocyclic compounds was synthesized including the core structure of the natural product (±)-γ-lycorane and structurally complex compounds based on the tetracyclic core of the erythrina alkaloids. The results came from multiple reactions, including the reaction of Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.Recommanded Product: Methyl 4-fluoro-3-nitrobenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2018,Journal of the American Chemical Society included an article by Wang, Yin-Xia; Qi, Shao-Long; Luan, Yu-Xin; Han, Xing-Wang; Wang, Shan; Chen, Hao; Ye, Mengchun. HPLC of Formula: 329-59-9. The article was titled 《Enantioselective Ni-Al Bimetallic Catalyzed exo-Selective C-H Cyclization of Imidazoles with Alkenes》. The information in the text is summarized as follows:

A Ni-Al bimetallic catalyzed enantioselective C-H exo-selective cyclization of imidazoles with alkenes has been developed. A series of bi- or polycyclic imidazoles with β-stereocenter were obtained in up to 98% yield and >99% ee. The bifunctional SPO ligand-promoted bimetallic catalysis proved to be critical to this challenging stereocontrol. In the experiment, the researchers used many compounds, for example, Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9HPLC of Formula: 329-59-9)

Methyl 4-fluoro-3-nitrobenzoate(cas: 329-59-9) belongs to methyl benzoate. Methyl benzoate reacts at both the ring and the ester, depending on the substrate. Electrophiles attack the ring, illustrated by acid-catalysed nitration with nitric acid to give methyl 3-nitrobenzoate.HPLC of Formula: 329-59-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics