Related Products of 32454-36-7, A common heterocyclic compound, 32454-36-7, name is Ethyl 2-(4-bromophenyl)-2-methylpropanoate, molecular formula is C12H15BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B: 2-(4-Bromophenyl)-2-methylpropan-l-olTo a solution of 2-(4-bromophenyl)-2-methylpropanoate (8.9 g, 33 mmol) in THF(100 mL) under nitrogen was added LiAltL; (1.6 g, 43 mmol) in portions at 0 C. The resulting solution was stirred at 0 C for 1 hour before the addition of saturated aqueous NFLjCl (50 mL). The mixture was then extracted with EtOAc (3×80 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo. The crude residue was purified by MPLC on Silica gel with 2-5 % EtOAc/hexane to afford 2-(4-bromophenyl)-2- methylpropan-l-ol as a colorless oil. MS ESI: [M+H]+ m/z 229, 231 ; 1H NMR (400 MHz, CDC13) delta 7.47 (d, J= 6.8 Hz, 2H), 7.28 (d, J= 6.8 Hz, 2H), 3.61 (s, 2H), 1.58 (s, 6H).
The synthetic route of 32454-36-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BRUBAKER, Jason; DINSMORE, Christopher J.; HOFFMAN, Dawn Marie; JUNG, Joon; LIU, Duan; PETERSON, Scott; SIU, Tony; TORRES, Luis E.; ZHANG, Hongjun; WEI, Zhongyong; SHI, Feng; WO2013/40863; (2013); A1;,
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