Category: 3196-23-4

Reference of 3196-23-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 2.5 g of zinc, 5.53 g (25 mmol) of bromo ester 1, a catalytic amount (5 mg) of HgCl2, and 40 mL of benzene was heated for 3 h under reflux. The mixture was cooled, 10 mmol of aldehyde 4a-4i was added, and the mixture was heated for 2 h under reflux.After cooling, the mixture was treated with 5% aqueous acetic acid, the organic phase was separated and dried over Na2SO4, and the solvent was distilled off.The crystalline product (7a-7i) was recrystallized from ethyl acetate. Treatment of the residue with methanol led to crystallization of compound 11a-11d which was recrystallized from methanol.

The chemical industry reduces the impact on the environment during synthesis Methyl 1-bromocyclohexanecarboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Kirillov; Nikiforova; Vasyanin; Dmitriev; Russian Journal of Organic Chemistry; vol. 51; 4; (2015); p. 513 – 517; Zhurnal Organicheskoi Khimii; vol. 51; (2015); p. 530 – 534,5;,
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Application of 3196-23-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3196-23-4 name is Methyl 1-bromocyclohexanecarboxylate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 2.5 g of zinc, 5.53 g (25 mmol) of bromo ester 1, a catalytic amount (5 mg) of HgCl2, and 40 mL of benzene was heated for 3 h under reflux. The mixture was cooled, 10 mmol of aldehyde 4a-4i was added, and the mixture was heated for 2 h under reflux.After cooling, the mixture was treated with 5% aqueous acetic acid, the organic phase was separated and dried over Na2SO4, and the solvent was distilled off.The crystalline product (7a-7i) was recrystallized from ethyl acetate. Treatment of the residue with methanol led to crystallization of compound 11a-11d which was recrystallized from methanol.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 1-bromocyclohexanecarboxylate, and friends who are interested can also refer to it.

Reference:
Article; Kirillov; Nikiforova; Vasyanin; Dmitriev; Russian Journal of Organic Chemistry; vol. 51; 4; (2015); p. 513 – 517; Zhurnal Organicheskoi Khimii; vol. 51; (2015); p. 530 – 534,5;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 3196-23-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows.

AD3 (R1 and R2 together formed a cyclohexyl ring) was mixed with BocNHOH in DMSO and treated with NaH (1 equiv.) at 50 0C overnight. After aqueous work up, the crude mixture was then treated with TFA to afford AD4 (R1 and R2 together formed a cyclohexyl ring) as the TFA salt.

The chemical industry reduces the impact on the environment during synthesis Methyl 1-bromocyclohexanecarboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; SCHERING CORPORATION; ZHU, Zhaoning; GREENLEE, William, J.; LI, Hongmei; VICAREL, Monica, L.; QIN, Jun; DHONDI, Pawan, Kumar; HUANG, Xianhai; PALANI, Anandan; LIU, Xiaoxiang; SUN, Zhong-Yue; JOSIEN, Hubert B.; XU, Ruo; COLE, David, James; BURNETT, Duane, A.; BENNETT, Chad, E.; MCCRACKEN, Troy, M.; MACCOSS, Malcolm; WO2010/56722; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 1-bromocyclohexanecarboxylate

General procedure: Synthesis. The mixture of zinc (3.0 g, 46 mmol), methyl 1-bromocycloalkanecarboxylate (12 mmol), HgCl2 (5 mg), and N,N-bis(arylmethylidene)benzidine 3 (5 mmol) in dry toluene(20 mL) with 2mL of HMPA was heated for 4 h under reflux and then cooled down, decanted from the zinc excess, and treated with 5% acetic acid. Organic layer was separated, and the aqueous layer was twice extracted with ethyl acetate. The combined organic layers were dried over Na2SO4 and then concentrated. The residue was purified by the recrystallization from p-xylene to give the reaction products 6a-i and 7a-k as white or Slightly colored Solids.

The synthetic route of 3196-23-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kirillov; Nikiforova; Baibarodskikh; Zakharova; Govorushkin; Journal of Chemistry; vol. 2019; (2019);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3196-23-4, HPLC of Formula: C8H13BrO2

A mixture of 3 g of finely chipped zinc, catalytic amount of mercuricchloride, 30 ml of anhydrous benzene, 1 ml of HMPTA, 25 mmol (5.53 g) of methyl 1-bromocyclohexanecarboxylate, and10 mmol (2.03 g) of compound II was boiled for 4 h, cooled, and decanted from the excess zinc; then it was hydrolyzed with5% acetic acid; the organic layer was separated, and the reaction products were twice extracted from the aqueous layer withethyl acetate. When the extract was dried with anhydrous sodium sulfate, the solvents were distilled, and compound III wasrecrystallized from ethanol. The yield was 1.85 g (59%)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kirillov; Nikifirova; Dmitriev; Baibarodskikh; Journal of Structural Chemistry; vol. 57; 6; (2016); p. 1263 – 1265; Zh. Strukt. Kim.; vol. 57; 6; (2016); p. 1327 – 1329,3;,
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Ester – an overview | ScienceDirect Topics

Related Products of 3196-23-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

a. Benzhydryl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(1-methoxycarbonylcyclohexyloxyimino)acetate Benzhydryl 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(hydroxyimino)acetate (2.0 g) was treated with methyl 1-bromocyclohexane carboxylate as described in Example 5a to give the title compound (1.7 g, 69%) as a white solid, m.p. 180-182 C. (ethyl acetate/hexane). [Found: C: 73.73; H: 5.60; N: 5.69. C45 H41 N3 O5 S requires C: 73.45; H: 5.62; N: 5.71%] numax (KBr) 3406, 2945, 1751, and 1528cm-1, deltaH (CDCl3) 1.36 (5H, m), 1.72 (3H, m), 2.00 (2H, m), 3.69 (3H, s), 6.46 (1H, s), 6.71 (1H, s), 7.15 (1H, s), 7.29 and 7.34 (25H, m).

The synthetic route of Methyl 1-bromocyclohexanecarboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beecham Group P.L.C.; US4816452; (1989); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H13BrO2

To a suspension of chromium (II) chloride (1. 00 g, 8. 10 MMOL) and lithium iodide (0. 087 G, 0. 648 MMOL) in tetrahydrofuran (20 mL) was added 4- [2- (5-METHYL-2- phenyl-1, 3-oxazol-4-yl) ethoxy] BENZALDEHYDE (Preparation 1) (1. 00 g, 3. 24 MMOL) and methyl 1-bromocyclohexanoate (1. 07 g, 4. 85 MMOL). The resulting mixture was heated at 50 C until TLC analysis indicated the reaction was complete. The mixture was cooled to ambient temperature and satuarted aqueous sodium chloride (15 mL) was added. The resulting mixture was stirred for 15 minutes, then partitioned between water and ethyl acetate. The organic phase was washed with water and dried (anhydrous magnesium sulfate), filtered and evaporated. The residue was purified by flash column chromatography (hexanes to 50% ethyl acetate/hexanes) to yield the title compound as a colorless oil (0. 797 G, 55%). LRMS (M/Z) : 450 (M+H).

The synthetic route of 3196-23-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; WO2004/92145; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics