Category: 3196-15-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3196-15-4, name is Methyl 2-bromobutyrate, A new synthetic method of this compound is introduced below., Recommanded Product: Methyl 2-bromobutyrate

Double-benzyl-isoquinoline (Formula in, X = Br) 6.85g, 2- bromo-7-bromo-butyrate weighed 4.50g wasdissolved in N, N- dimethyl Formamide 100mL, 500mL three-neck flask was added, mixed by stirring, cooled to-10 C, and the reaction was stirred 24h incubation After filtration, filtrate was washed with a small amount of5% hydrobromic acid and, the solvent was distilled off under reduced pressure to a volume of the liquid reducedto 1/4, crystallization at room temperature 8h, Filtered and the filtrate evaporated under reduced pressure to 50%of water, cooled to 5 C to crystallize overnight, filtered and the solid was dried at 60 C 4h, to give the lightThe product 5.20g yellow powder in a yield of 70.29%, a purity of 96.47% (HPLC).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shandong Normal University; LIU, YUFA; ZHANG, MENG; MAO, FEIFEI; CHEN, DONGMEI; ZHANG, JINE; (22 pag.)CN103910740; (2016); B;,
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Related Products of 3196-15-4, The chemical industry reduces the impact on the environment during synthesis 3196-15-4, name is Methyl 2-bromobutyrate, I believe this compound will play a more active role in future production and life.

5-Ethyl-2-pyrazin-2-yl-thiazol-4-ol: A solution of pyrazine-2-carbothioamide (1 g, 7.19 mmol) in ethanol (20 ml) was treated with methyl 2-bromobutyrate (1.56 g, 992 mul, 8.62 mmol) an pyridine (853 mg, 872 mul, 10.8 mmol) and heated to reflux for 2 hours. The reaction mixture was cooled and concentrated to dryness under reduced pressure, and the resulting solid was filtered and washed with diethyl ether to provide 5-ethyl-2-pyrazin-2-yl-thiazol-4-ol (0.740 g, 50%) which was used directly without further purification. MS (M+H)=208.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hoffmann-La Roche Inc; Bhagirath, Niala; Brameld, Kenneth Albert; Kennedy-Smith, Joshua; US2013/90334; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3196-15-4, name is Methyl 2-bromobutyrate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H9BrO2

Example 11; Preparation of intermediate 2-(4-chloro-2-formyl-phenoxy)-butyric acid methyl ester; A mixture of 5-chloro-2-hydroxy-benzaldehyde (156 g, 1 mol), 2-bromo-butyric acid methyl ester (271 g, 1.5 mol), KI (2 g, 0.012 mol) and K2CO3 (276 g, 2 mol) in DMF (500 mL) was heated at 130 0C for 2 h. After cooled to room temperature, the mixture was concentrated. The residue was partitioned between EtOAc and water. The organic layer was washed with water, brine, dried over anhydrous Na2SO4 and concentrated to give the title compound (240 g).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3196-15-4.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; CHEN, Li; HAN, Xingchun; YANG, Song; ZHANG, Zhuming; WO2010/121995; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 3196-15-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3196-15-4 as follows.

[1074] Step 4: methyl 2-(6-(hydroxymethyl)-2-((4-methylbenzoyl)imino)benzo[d]thiazol-3(2H)-yl)butanoate[1075] To a solution of N-(6-(hydroxymethyl)benzo[d]thiazol-2(3H)-ylidene)-4-methylbenzamide (500 mg, 1.676 mmol) prepared in Step 3 in N,N-dimethylformamide (10 mL) were added potassium carbonate (695 mg, 5.028 mmol) and methyl 2-bromobutyrate (289 uL, 2.514 mmol). The reaction mixture was stirred at 50 ? overnight. .The reaction mixture was quenched with water and then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, filtered, and then evaporated. Isopropyl ether was added to the resulting residue and then filtered. The resulting solid was dried under reduced pressure to give 470 mg of the titled compound as a white solid (Yield: 70%).[1076] 1H NMR (CDCl3, 400 MHz); 8.19 (d, 2H), 7.76 (s, 1H), 7.44 (d, 1H), 7.26 (m, 3H), 5.60 (brs, 1H), 4.79 (s, 2H), 3.65 (s, 3H), 2.51 (m, 2H), 2.42 (s, 3H), 1.97 (s, 1H), 1.57 (s, 2H), 0.89 (t, 3H).

According to the analysis of related databases, 3196-15-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YUHAN CORPORATION; HUR, Youn; KIM, Dong-Hyun; KIM, Eun-Kyung; PARK, Jin-Hwi; JOO, Jae-Eun; KANG, Ho-Woong; OH, Se-Woong; KIM, Dong-Kyun; AHN, Kyoung-Kyu; WO2013/43001; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3196-15-4, name is Methyl 2-bromobutyrate, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 3196-15-4

DMF (3 mL) mixed solution of 5-chloro-4- (6-fluoro-2-mercaptobenzothiazole-5-yl) -1,2-tetramethylene-4-pyrazoline-3-one (240 mg, 0.67 mmol), cesium carbonate (264 mg, 1.2mmol) was stirred for 10 min, then 2-bromo-butyric acid methyl (107muL, 1.2mmol) was added and the mixture was stirred at room temperature for 24 hours. After the reaction, water was added to the reaction solution and extracted with chloroform. The organic layer was dried anhydrous magnesium sulfate and concentrated under reduced pressure. the obtained crude product was purified by eluting through silica gel column chromatography (ethyl acetate) to give a yellow oil of 2-[{5-(5-chloro-3-oxo-1,2-tetramethylene pyrazoline-4-yl)-6-fluoro-benzothiazol-2-yl} thio] methyl butanoate (171 mg, yield: 56%).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3196-15-4.

Reference:
Patent; SAGAMI CHEMICAL RESEARCH INSTITUTE; KAKEN PHARMACEUTICAL COMPANY LIMITED; KOBAYASHI, OSAMU; TAKATSUNA, REIKO; NIIKURA, NAOKO; MATSUKAWA, TOMOKO; NAKAMURA, SHINJI; HIRAI, KENJI; KOCHI, SHINICHIRO; KAWANISHI, NAOKI; YAMADA, OSAMU; (31 pag.)JP2016/56156; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 3196-15-4,Some common heterocyclic compound, 3196-15-4, name is Methyl 2-bromobutyrate, molecular formula is C5H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-(2-amino-4-chloro-6-fluoro-3-hydroxyphenyl)-5-chloro-1,2-oxydiethylene-4-pyrazolin-3-one(300mg, 0.860mmol) in acetonitrile (12 mL ) was added potassium carbonate (300 mg, 2.15 mmol) and methyl-2-bromobutyrate (230muL, 1.72mmol) and the mixture was stirred at room temperature for 23 hours. After completion of the reaction, water (50mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (50mL × 3). After drying the combined organic layers over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography – (ethyl acetate: methanol – Le = 9: 1) to give 5-chloro-4-(8-chloro-2-ethyl-6-fluoro-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-5-yl)-1,2-oxydiethylene-4-pyrazolin-3-one white solid (231 mg, yield: 64%)

The synthetic route of 3196-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SAGAMI CHEMICAL RESEARCH INSTITUTE; KAKEN PHARMACEUTICAL COMPANY LIMITED; KOBAYASHI, OSAMU; TAKATSUNA, REIKO; NIIKURA, NAOKO; TATENO, TOMOKO; NAKAMURA, SHINJI; HIRAI, KENJI; KOCHI, SHINICHIRO; KAWANISHI, NAOKI; YAMADA, OSAMU; (76 pag.)JP2016/60742; (2016); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3196-15-4, name is Methyl 2-bromobutyrate, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H9BrO2

Sodium sulfite (12.61 g, 0.1 mol) and sodium bicarbonate (8.40 g, 0.105 mol) were added to 100 mL of water and 10 mL of tetrahydrofuran and then stirred. When the salts dissolved completely, IX (18.05 g, 0.05 mol) was added and the temperature of 15 C was maintained for 12 h, while stirring. Upon the reaction completion, the precipitated solid was obtained by filtration and the filter cake was directly added to a stirred mixture of 2-bromobutyric acid methyl ester (9.05 g, 0.05 mol) and methanol (200 mL), which was then heated to 60 C. The progress of the reaction was monitored by GC up to complete disappearance of 2-bromobutyric acid methyl ester. The resulting mixture was then cooled to room temperature and the first precipitated solid was removed by filtration. VI was further crystallized from the filtrate. Yield: 18.27 g (85.6 %). Melting point: 47.9-48.9 C.

The synthetic route of 3196-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shi, Yun-Long; Wang, Ling; Qian, Chao; Tao, Ming; Liao, Zu-Tai; Chen, Xin-Zhi; Chemical Papers; vol. 69; 9; (2015); p. 1237 – 1243;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 3196-15-4, name is Methyl 2-bromobutyrate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3196-15-4, Safety of Methyl 2-bromobutyrate

To a solution of naphthalene-2,7-diol (5.0 g, 31 mmol) in acetone (200 mL) was added cesium carbonate (10.1 g, 31 mmol) at room temperature under a nitrogen atmosphere with stirring. After the addition, the mixture was stirred at room temperature for 3 min and then methyl-2-bromobutyrate (5.6 g, 31 mmol) was added. The mixture was stirred at room temperature overnight and then filtered to remove solids. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (over silica gel with ethyl acetate and hexanes in volume ratios from 10 to 80 % as eluents) to give the title compound (3.9 g) as a solid. in NMR (CDCI3) delta 7.62-7.70 (m, 2H), 6.85-7.05 (m, 4H), 5.85 (s, 1H), 4.68-4.78 (m, 1H),3.75 (s, 3H), 2.00-2.10 (m, 2H), 1.08-1.15 (t, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; CREWS, Alvin, Donald, Jr.; DING, Amy, X.; TSENG, Chi-Ping; WO2012/87372; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 3196-15-4,Some common heterocyclic compound, 3196-15-4, name is Methyl 2-bromobutyrate, molecular formula is C5H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of pyridine-3-carbothioamide (1 g, 7.24 mmol) in EtOH (15 mL) and pyridine (1 mL, 12.3 mmol) was added methyl 2-bromobutanoate (1 mL, 8.68 mmol). The mixture was heated at reflux for 18 hours, after which it was cooled and concentrated. The crude 5-Ethyl-2-pyridin-3-yl-thiazol-4-ol was then redissolved in DMF (36 mL) at 0 C., and to the mixture was added 60% sodium hydride (751 mg, 18.8 mmol). After stirring for 15 min at rt, 1,1,1-trifluoro-N-phenyl-N-(trifluoromethylsulfonyl)methanesulfonamide (3.87 g, 10.8 mmol) was added. The mixture was reacted for 20 min, quenched with sat. NH4Cl, diluted with diethyl ether. The mixture was washed with water, and then brine. The organic layer was concentrated, and the resulting material chromatographed (5-55% EtOAc/Hexanes to give trifluoro-methanesulfonic acid 5-ethyl-2-pyridin-3-yl-thiazol-4-yl ester (0.85 g) as an orange oil.

The synthetic route of 3196-15-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; Alam, Muzaffar; Du Bois, Daisy Jo; Hawley, Ronald Charles; Minatti, Ana Elena; Kennedy-Smith, Joshua; Thakkar, Kshitij Chhabilbhai; Wilhelm, Robert Stephen; US2013/158066; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 3196-15-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3196-15-4, name is Methyl 2-bromobutyrate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 4: methyl 2-[2-(4-methylbenzoylimino)-6-(phenylcarbamoyl)benzo[d]thiazol-3(2H)-yl]butanoate To a solution of 2-(4-methylbenzamido)-N-phenylbenzo[d]thiazol-6-carboxamide (200 mg, 0.52 mmol) prepared in Step 3 in N,N-dimethylformamide (2.0 mL) was added dropwise potassium carbonate (216 mg, 1.56 mmol) and methyl 2-bromobutyrate (90 uL, 0.78 mmol). The reaction mixture was refluxed under stirring at 80 C. overnight. The reaction mixture was quenched with water and then extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered, and then evaporated. The residue was purified with silica gel column chromatography (n-hexaneethyl acetate=2/1, v/v) to give 200 mg of the titled compound as a white solid (Yield: 79%). 1H NMR (CDCl3, 400 MHz) delta 8.23 (s, 1H), 8.17 (d, 2H), 7.97 (d, 1H), 7.88 (s, 1H), 7.65 (d, 2H), 7.34-7.41 (m, 3H), 7.28 (d, 2H), 7.18 (t, 1H), 5.63 (m, 1H), 3.68 (s, 3H), 2.46-2.57 (m, 2H), 2.42 (s, 3H), 0.92 (t, 3H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; YUHAN CORPORATION; Hur, Youn; Kim, Dong-Hyun; Kim, Eun-Kyung; Park, Jin-Hwi; Joo, Jae-Eun; Kang, Ho-Woong; Oh, Se-Woong; Kim, Dong-Kyun; Ahn, Kyoung-Kyu; US2015/11528; (2015); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics